American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer

Journal of Clinical Oncology

Volumn 24, Issue 22, 2006, Pages 3693-3704

  Pfister, David G ^a   Laurie, Scott A ^a   Weinstein, Gregory S ^a   Mendenhall, William M ^a   Adelstein, David J ^a   Ang, K Kian ^a   Clayman, Gary L ^a   Fisher, Susan G ^a   Forastiere, Arlene A ^a   Harrison, Louis B ^a   Lefebvre, Jean Louis ^a   Leupold, Nancy ^a   List, Many A ^a   O'Malley, Bernard O ^a   Patel, Snehal ^a   Posner, Marshall R ^a   Schwartz, Michael A ^a   Wolf, Gregory T ^a  

^a AMERICAN SOCIETY OF CLINICAL ONCOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FLUOROURACIL;

CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL PRACTICE; CLINICAL TRIAL; DYSPHAGIA; FEBRILE NEUTROPENIA; HEALTH SERVICE; HUMAN; LARYNGECTOMY; LARYNX CANCER; MEDICAL EXPERT; MEDICAL LITERATURE; MEDICAL SOCIETY; MULTIPLE CYCLE TREATMENT; OUTCOME ASSESSMENT; PATIENT CARE; PATIENT SELECTION; PRACTICE GUIDELINE; PRESERVATION; PRIORITY JOURNAL; REVIEW; CANCER STAGING; CONTROLLED CLINICAL TRIAL; EVIDENCE BASED MEDICINE; LARYNX; LARYNX TUMOR; LYMPH NODE METASTASIS; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PATIENT PARTICIPATION; PHASE 3 CLINICAL TRIAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SURVIVAL; TRACHEOSTOMY; TREATMENT OUTCOME;

CLINICAL TRIALS, PHASE III; DEGLUTITION DISORDERS; EVIDENCE-BASED MEDICINE; HUMANS; LARYNGEAL NEOPLASMS; LARYNGECTOMY; LARYNX; LYMPHATIC METASTASIS; NEOPLASM STAGING; PATIENT PARTICIPATION; PATIENT SELECTION; PROSPECTIVE STUDIES; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS; SOCIETIES, MEDICAL; SURVIVAL ANALYSIS; TRACHEOSTOMY; TREATMENT OUTCOME;

EID: 33747032033     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2006.07.4559     Document Type: Review

References (179)

1. Jemal A, Murray T, Ward E, et al: Cancer statistics, 2005. CA Cancer J Clin 55:10-30, 2005
2. Myers EN, Suen JY, Myers JN, et al: Cancer of the Head and Neck (ed 4). Philadelphia, PA, Saunders, 2003
3. Piccirillo JF: Importance of comorbidity in head and neck cancer. Laryngoscope 110:593-602, 2000
4. Hong WK, Lippman SM, Itri LM, et al: Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 323:795-801, 1990
5. Lippman SM, Hong WK: Second malignant tumors in head and neck squamous cell carcinoma: The overshadowing threat for patients with early-stage disease. Int J Radiat Oncol Biol Phys 17:691-694, 1989
6. Breitbart W, Holland J: Psychosocial aspects of head and neck cancer. Semin Oncol 15:61-69, 1988
7. Dropkin MJ: Body image and quality of life after head and neck cancer surgery. Cancer Pract 7:309-313, 1999
8. McNeil BJ, Weichselbaum R, Pauker SG: Speech and survival: Tradeoffs between quality and quantity of life in laryngeal cancer. N Engl J Med 305:982-987, 1981
9. Miller SD, Sulica L: General principles of rehabilitation of speech, voice, and swallowing after treatment of head and neck cancer, in Harrison LB, Sessions RB, Hong WK (eds): Head and Neck Cancer: A Multidisciplinary Approach (ed 2). Philadelphia, PA, Lippincott-Raven, 2004
10. DeSanto LW, Olsen KD, Perry WC, et al: Quality of life after surgical treatment of cancer of the larynx. Ann Otol Rhinol Laryngol 104:763-769, 1995
11. Carl J, Andersen LJ, Pedersen M, et al: Prognostic factors of local control after radiotherapy in T1 glottic and supraglottic carcinoma of the larynx. Radiother Oncol 39:229-233, 1996
12. Cragle SP, Brandenburg JH: Laser cordectomy or radiotherapy: Cure rates, communication, and cost. Otolaryngol Head Neck Surg 108:648-654, 1993
13. Davis RK, Kelly SM, Parkin JL, et al: Selective management of early glottic cancer. Laryngoscope 100:1306-1309, 1990
14. de Graeff A, de Leeuw RJ, Ros WJ, et al: A prospective study on quality of life of laryngeal cancer patients treated with radiotherapy. Head Neck 21:291-296, 1999
15. Delsupehe KG, Zink I, Lejaegere M, et al: Voice quality after narrow-margin laser cordectomy compared with laryngeal irradiation. Otolaryngol Head Neck Surg 121:528-533, 1999
16. Dinshaw KA, Sharma V: Radiation therapy in early glottic carcinoma: Significance of prognostic factors and dose fractionation. Indian J Cancer 27:143-153, 1990
17. Eckel HE, Thumfart WF: Laser surgery for the treatment of larynx carcinomas: Indications, techniques, and preliminary results. Ann Otol Rhinol Laryngol 101:113-118, 1992
18. Fein DA, Lee WR, Hanlon AL, et al: Do overall treatment time, field size, and treatment energy influence local control of T1-T2 squamous cell carcinomas of the glottic larynx? Int J Radiat Oncol Biol Phys 34:823-831, 1996
19. Fujita M, Rudoltz MS, Canady DJ, et al: Second malignant neoplasia in patients with T1 glottic cancer treated with radiation. Laryngoscope 108:1853-1855, 1998
20. Gowda RV, Henk JM, Mais KL, et al: Three weeks radiotherapy for T1 glottic cancer: The Christie and Royal Marsden Hospital experience. Radiother Oncol 68:105-111, 2003
21. Hayakawa K, Mitsuhashi N, Akimoto T, et al: The effect of overall treatment time of radiation therapy on local control of T1-stage squamous cell carcinoma of the glottis. Laryngoscope 106:1545-1547, 1996
22. Laccourreye O, Veivers D, Hans S, et al: Chemotherapy alone with curative intent in patients with invasive squamous cell carcinoma of the pharyngolarynx classified as T1-T4N0M0 complete clinical responders. Cancer 92:1504-1511, 2001
23. Marshak G, Brenner B, Shvero J, et al: Prognostic factors for local control of early glottic cancer: The Rabin Medical Center retrospective study on 207 patients. Int J Radiat Oncol Biol Phys 43:1009-1013, 1999
24. McGuirt WF, Blalock D, Koufman JA, et al: Comparative voice results after laser resection or irradiation of T1 vocal cord carcinoma. Arch Otolaryngol Head Neck Surg 120:951-955, 1994
25. Mendenhall WM, Amdur RJ, Morris CG, et al: T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 19:4029-4036, 2001
26. Morton RP: Laryngeal cancer: Quality-of-life and cost-effectiveness. Head Neck 19:243-250, 1997
27. Myers EN, Wagner RL, Johnson JT: Microlaryngoscopic surgery for T1 glottic lesions: A cost-effective option. Ann Otol Rhinol Laryngol 103:28-30, 1994
28. Nguyen C, Naghibzadeh B, Black MJ, et al: Carcinoma in situ of the glottic larynx: Excision or irradiation? Head Neck 18:225-228, 1996
29. Nishimura Y, Nagata Y, Okajima K, et al: Radiation therapy for T1,2 glottic carcinoma: Impact of overall treatment time on local control. Radiother Oncol 40:225-232, 1996
30. Nordgren M, Abendstein H, Jannert M, et al: Health-related quality of life five years after diagnosis of laryngeal carcinoma. Int J Radiat Oncol Biol Phys 56:1333-1343, 2003
31. Pearson BW, Salassa JR: Transoral laser microresection for cancer of the larynx involving the anterior commissure. Laryngoscope 113:1104-1112, 2003
32. Peretti G, Piazza C, Bolzoni A, et al: Analysis of recurrences in 322 Tis, T1, or T2 glottic carcinomas treated by carbon dioxide laser. Ann Otol Rhinol Laryngol 113:853-858, 2004
33. Rosier JF, Gregoire V, Counoy H, et al: Comparison of external radiotherapy, laser microsurgery and partial laryngectomy for the treatment of T1N0M0 glottic carcinomas: A retrospective evaluation. Radiother Oncol 48:175-183, 1998
34. Rothfield RE, Myers EN, Johnson JT: Carcinoma in situ and microinvasive squamous cell carcinoma of the vocal cords. Ann Otol Rhinol Laryngol 100:793-796, 1991
35. Sagar SM, McKenna G, Nolan MC: A clinical audit of glottic cancer in Nova Scotia: A paradigm for effectiveness research. Clin Oncol (R Coll Radiol) 6:14-23, 1994
36. Schuller DE, Trudeau M, Bistline J, et al: Evaluation of voice by patients and close relatives following different laryngeal cancer treatments. J Surg Oncol 44:10-14, 1990
37. Slevin NJ, Vasanthan S, Dougal M: Relative clinical influence of tumor dose versus dose per fraction on the occurrence of late normal tissue morbidity following larynx radiotherapy. Int J Radiat Oncol Biol Phys 25:23-28, 1993
38. Steiner W: Results of curative laser microsurgery of laryngeal carcinomas. Am J Otolaryngol 14:116-121, 1993
39. Steiner W, Ambrosch P, Rodel RM, et al: Impact of anterior commissure involvement on local control of early glottic carcinoma treated by laser microresection. Laryngoscope 114:1485-1491, 2004
40. Stevens G, Castle G, O'Brien CJ: Treatment of early carcinoma of the vocal cords by radiotherapy. Australas Radiol 38:119-122, 1994
41. Stoeckli SJ, Guidicelli M, Schneider A, et al: Quality of life after treatment for early laryngeal carcinoma. Eur Arch Otorhinolaryngol 258:96-99, 2001
42. Wang CC, Efird JT: Does prolonged treatment course adversely affect local control of carcinoma of the larynx? Int J Radiat Oncol Biol Phys 29:657-660, 1994
43. Zeitels SM: Phonomicrosurgical treatment of early glottic cancer and carcinoma in situ. Am J Surg 172:704-709, 1996
44. Chevalier D, Watelet JB, Darras JA, et al: Supraglottic hemilaryngopharyngectomy plus radiation for the treatment of early lateral margin and pyriform sinus carcinoma. Head Neck 19:1-5, 1997
45. Fein DA, Mendenhall WM, Parsons JT, et al: T1-T2 squamous cell carcinoma of the glottic larynx treated with radiotherapy: A multivariate analysis of variables potentially influencing local control. Int J Radiat Oncol Biol Phys 25:605-611, 1993
46. Howell-Burke D, Peters LJ, Goepfert H, et al: T2 glottic cancer: Recurrence, salvage, and survival after definitive radiotherapy. Arch Otolaryngol Head Neck Surg 116:830-835, 1990
47. Laccourreye H, Laccourreye O, Weinstein G, et al: Supracricoid laryngectomy with cricohyoidopexy: A partial laryngeal procedure for selected supraglottic and transglottic carcinomas. Laryngoscope 100:735-741, 1990
48. Laccourreye O, Weinstein G, Brasnu D, et al: Vertical partial laryngectomy: A critical analysis of local recurrence. Ann Otol Rhinol Laryngol 100:68-71, 1991
49. McLaughlin MP, Parsons JT, Fein DA, et al: Salvage surgery after radiotherapy failure in T1-T2 squamous cell carcinoma of the glottic larynx. Head Neck 18:229-235, 1996
50. Motta G, Esposito E, Cassiano B, et al: T1-T2-T3 glottic tumors: Fifteen years experience with CO2 laser. Acta Otolaryngol Suppl 527:155-159, 1997
51. Piquet JJ, Chevalier D: Subtotal laryngectomy with crico-hyoido- epiglotto-pexy for the treatment of extended glottic carcinomas. Am J Surg 162:357-361, 1991
52. Rudert HH, Werner JA: Endoscopic resections of glottic and supraglottic carcinomas with the CO2 laser. Eur Arch Otorhinolaryngol 252:146-148, 1995
53. Slevin NJ, Hendry JH, Roberts SA, et al: The effect of increasing the treatment time beyond three weeks on the control of T2 and T3 laryngeal cancer using radiotherapy. Radiother Oncol 24:215-220, 1992
54. Spector JG, Sessions DG, Chao KS, et al: Management of stage II (T2N0M0) glottic carcinoma by radiotherapy and conservation surgery. Head Neck 21:116-123, 1999
55. Turesson I, Sandberg N, Mercke C, et al: Primary radiotherapy for glottic laryngeal carcinoma stage I and II: A retrospective study with special regard to failure patterns. Acta Oncol 30:357-362, 1991
56. Viani L, Stell PM, Dalby JE: Recurrence after radiotherapy for glottic carcinoma. Cancer 67:577-584, 1991
57. Ambrosch P, Kron M, Steiner W: Carbon dioxide laser microsurgery for early supraglottic carcinoma. Ann Otol Rhinol Laryngol 107:680-688, 1998
58. de Vincentiis M, Minni A, Gallo A, et al: Supracricoid partial laryngectomies: Oncologic and functional results. Head Neck 20:504-509, 1998
59. Eckel HE: Endoscopic laser resection of supraglottic carcinoma. Otolaryngol Head Neck Surg 117:681-687, 1997
60. Garden AS, Morrison WH, Ang KK, et al: Hyperfractionated radiation in the treatment of squamous cell carcinomas of the head and neck: A comparison of two fractionation schedules. Int J Radiat Oncol Biol Phys 31:493-502, 1995
61. Hinerman RW, Mendenhall WM, Amdur RJ, et al: Carcinoma of the supraglottic larynx: Treatment results with radiotherapy alone or with planned neck dissection. Head Neck 24:456-467, 2002
62. Iro H, Waldfahrer F, Altendorf-Hofmann A, et al: Transoral laser surgery of supraglottic cancer: Follow-up of 141 patients. Arch Otolaryngol Head Neck Surg 124:1245-1250, 1998
63. Kim RY, Marks ME, Salter MM: Early-stage glottic cancer: Importance of dose fractionation in radiation therapy. Radiology 182:273-275, 1992
64. Le QT, Fu KK, Kroll S, et al: Influence of fraction size, total dose, and overall time on local control of T1-T2 glottic carcinoma. Int J Radiat Oncol Biol Phys 39:115-126, 1997
65. Lee NK, Goepfert H, Wendt CD: Supraglottic laryngectomy for intermediate-stage cancer: UT MD Anderson Cancer Center experience with combined therapy. Laryngoscope 100:831-836, 1990
66. Lutz CK, Johnson JT, Wagner RL, et al: Supraglottic carcinoma: Patterns of recurrence. Ann Otol Rhinol Laryngol 99:12-17, 1990
67. Mancuso AA, Mukherji SK, Schmalfuss I, et al: Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma. J Clin Oncol 17:631-637, 1999
68. Motta G, Esposito E, Testa D, et al: CO2 laser treatment of supraglottic cancer. Head Neck 26:442-446, 2004
69. Parsons JT, Mendenhall WM, Stringer SP, et al: Radiotherapy alone for moderately advanced laryngeal cancer (T2-T3). Semin Radiat Oncol 2:158-162, 1992
70. Parsons JT, Mendenhall WM, Stringer SP, et al: Salvage surgery following radiation failure in squamous cell carcinoma of the supraglottic larynx. Int J Radiat Oncol Biol Phys 32:605-609, 1995
71. Rudert HH, Werner JA, Hoft S: Transoral carbon dioxide laser resection of supraglottic carcinoma. Ann Otol Rhinol Laryngol 108:819-827, 1999
72. Spriano G, Antognoni P, Piantanida R, et al: Conservative management of T1-T2N0 supraglottic cancer: A retrospective study. Am J Otolaryngol 18:299-305, 1997
73. van der Voet JC, Keus RB, Hart AA, et al: The impact of treatment time and smoking on local control and complications in T1 glottic cancer. Int J Radiat Oncol Biol Phys 42:247-255, 1998
74. Wendt CD, Peters LJ, Ang KK, et al: Hyperfractionated radiotherapy in the treatment of squamous cell carcinomas of the supraglottic larynx. Int J Radiat Oncol Biol Phys 17:1057-1062, 1989
75. Yu E, Shenouda G, Beaudet MP, et al: Impact of radiation therapy fraction size on local control of early glottic carcinoma. Int J Radiat Oncol Biol Phys 37:587-591, 1997
76. Fu KK, Pajak TF, Trotti A, et al: A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int J Radiat Oncol Biol Phys 48:7-16, 2000
77. Forastiere AA, Goepfert H, Maor M, et al: Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349:2091-2098, 2003
78. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer: The Department of Veterans Affairs Laryngeal Cancer Study Group. N Engl J Med 324:1685-1690, 1991
79. Adelstein DJ, Lavertu P, Saxton JP, et al: Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck. Cancer 88:876-883, 2000
80. Adelstein DJ, Saxton JP, Lavertu P, et al: A phase III randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer: Preliminary results. Head Neck 19:567-575, 1997
81. Lefebvre JL, Chevalier D, Luboinski B, et al: Larynx preservation in pyriform sinus cancer: Preliminary results of a European Organization for Research and Treatment of Cancer phase III trial - EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst 88:890-899, 1996
82. Richard JM, Sancho-Garnier H, Pessey JJ, et al: Randomized trial of induction chemotherapy in larynx carcinoma. Oral Oncol 34:224-228, 1998
83. Bhalavat RL, Fakih AR, Mistry RC, et al: Radical radiation vs surgery plus post-operative radiation in advanced (resectable) supraglottic larynx and pyriform sinus cancer: A prospective randomized study. Eur J Surg Oncol 29:750-756, 2003
84. Brizel DM, Albers ME, Fisher SR, et al: Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med 338:1798-1804, 1998
85. Jeremic B, Shibamoto Y, Milicic B, et al: Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: A prospective randomized trial. J Clin Oncol 18:1458-1464, 2000
86. Bourhis J, Etessami A, Wilbault P, et al: Altered fractionated radiotherapy in the management of head and neck carcinomas: Advantages and limitations. Curr Opin Oncol 16:215-219, 2004
87. Browman GP, Hodson DI, Mackenzie RJ, et al: Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer: A systematic review of the published literature with subgroup analysis. Head Neck 23:579-589, 2001
88. Pignon JP, Bourhis J, Domenge C, et al: Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data - MACH-NC Collaborative Group: Meta-analysis of chemotherapy on head and neck cancer. Lancet 355:949-955, 2000
89. Bron L, Brossard E, Monnier P, et al: Supracricoid partial laryngectomy with cricohyoidoepiglottopexy and cricohyoidopexy for glottic and supraglottic carcinomas. Laryngoscope 110:627-634, 2000
90. Davis RK, Kriskovich MD, Galloway EB III, et al: Endoscopic supraglottic laryngectomy with postoperative irradiation. Ann Otol Rhinol Laryngol 113:132-138, 2004
91. Dufour X, Hans S, De Mones E, et al: Local control after supracricoid partial laryngectomy for "advanced" endolaryngeal squamous cell carcinoma classified as T3. Arch Otolaryngol Head Neck Surg 130:1092-1099, 2004
92. Flores TC, Wood BG, Levine HL, et al: Factors in successful deglutition following supraglottic laryngeal surgery. Ann Otol Rhinol Laryngol 91:579-583, 1982
93. Karp DD, Vaughan CW, Carter R, et al: Larynx preservation using induction chemotherapy plus radiation therapy as an alternative to laryngectomy in advanced head and neck cancer: A long-term follow-up report. Am J Clin Oncol 14:273-279, 1991
94. Laccourreye O, Brasnu D, Biacabe B, et al: Neo-adjuvant chemotherapy and supracricoid partial laryngectomy with cricohyoidopexy for advanced endolaryngeal carcinoma classified as T3-T4: 5-year oncologic results. Head Neck 20:595-599, 1998
95. Laccourreye O, Hans S, Borzog-Grayeli A, et al: Complications of postoperative radiation therapy after partial laryngectomy in supraglottic cancer: A long-term evaluation. Otolaryngol Head Neck Surg 122:752-757, 2000
96. List MA, Ritter-Sterr CA, Baker TM, et al: Longitudinal assessment of quality of life in laryngeal cancer patients. Head Neck 18:1-10, 1996
97. Marioni G, Marchese-Ragona R, Ottaviano G, et al: Supracricoid laryngectomy: Is it time to define guidelines to evaluate functional results? A review. Am J Otolaryngol 25:98-104, 2004
98. McConnel FM, Mendelsohn MS, Logemann JA: Manofluorography of deglutition after supraglottic laryngectomy. Head Neck Surg 9:142-150, 1987
99. Pfister DG, Strong E, Harrison L, et al: Larynx preservation with combined chemotherapy and radiation therapy in advanced but resectable head and neck cancer. J Clin Oncol 9:850-859, 1991
100. Rademaker AW, Logemann JA, Pauloski BR, et al: Recovery of postoperative swallowing in patients undergoing partial laryngectomy. Head Neck 15:325-334, 1993
101. Sewnaik A, van den Brink JL, Wieringa MH, et al: Surgery for recurrent laryngeal carcinoma after radiotherapy: Partial laryngectomy or total laryngectomy for a better quality of life? Otolaryngol Head Neck Surg 132:95-98, 2005
102. Terrell JE, Fisher SG, Wolf GT: Long-term quality of life after treatment of laryngeal cancer: The Veterans Affairs Laryngeal Cancer Study Group. Arch Otolaryngol Head Neck Surg 124:964-971, 1998
103. Vachin F, Hans S, Atlan D, et al: Long term results of exclusive chemotherapy for glottic squamous cell carcinoma complete clinical responders after induction chemotherapy [French]. Ann Otolaryngol Chir Cervicofac 121:140-147, 2004
104. Vokes EE, Stenson K, Rosen FR, et al: Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: Curative and organ-preserving therapy for advanced head and neck cancer. J Clin Oncol 21:320-326, 2003
105. Weber RS, Berkey BA, Forastiere A, et al: Outcome of salvage total laryngectomy following organ preservation therapy: The Radiation Therapy Oncology Group trial 91-11. Arch Otolaryngol Head Neck Surg 129:44-49, 2003
106. Weinstein GS, El-Sawy MM, Ruiz C, et al: Laryngeal preservation with supracricoid partial laryngectomy results in improved quality of life when compared with total laryngectomy. Laryngoscope 111:191-199, 2001
107. Weinstein GS, Laccourreye O, Ruiz C, et al: Larynx preservation with supracricoid partial laryngectomy with cricohyoidoepiglottopexy: Correlation of videostroboscopic findings and voice parameters. Ann Otol Rhinol Laryngol 111:1-7, 2002
108. Lavertu P, Bonafede JP, Adelstein DJ, et al: Comparison of surgical complications after organ-preservation therapy in patients with stage III or IV squamous cell head and neck cancer. Arch Otolaryngol Head Neck Surg 124:401-406, 1998
109. Fein DA, Hanlon AL, Lee WR, et al: Neck failure in T2N0 squamous cell carcinoma of the true vocal cords: The Fox Chase experience and review of the literature. Am J Clin Oncol 20:154-157, 1997
110. Garden AS, Forster K, Wong PF, et al: Results of radiotherapy for T2N0 glottic carcinoma: Does the "2" stand for twice-daily treatment? Int J Radiat Oncol Biol Phys 55:322-328, 2003
111. Johansen LV, Grau C, Overgaard J: Glottic carcinoma-patterns of failure and salvage treatment after curative radiotherapy in 861 consecutive patients. Radiother Oncol 63:257-267, 2002
112. McGuirt WF, McCabe BF: Significance of node biopsy before definitive treatment of cervical metastatic carcinoma. Laryngoscope 88:594-597, 1978
113. End results of a prospective trial on elective lateral neck dissection vs type III modified radical neck dissection in the management of supraglottic and transglottic carcinomas: Brazilian Head and Neck Cancer Study Group. Head Neck 21:694-702, 1999
114. Argiris A, Stenson KM, Brockstein BE, et al: Neck dissection in the combined-modality therapy of patients with locoregionally advanced head and neck cancer. Head Neck 26:447-455, 2004
115. Armstrong J, Pfister D, Strong E, et al: The management of the clinically positive neck as part of a larynx preservation approach. Int J Radiat Oncol Biol Phys 26:759-765, 1993
116. Barkley HT Jr, Fletcher GH, Jesse RH, et al: Management of cervical lymph node metastases in squamous cell carcinoma of the tonsillar fossa, base of tongue, supraglottic larynx, and hypopharynx. Am J Surg 124:462-467, 1972
117. Bernier J, Thames HD, Smith CD, et al: Tumor response, mucosal reactions and late effects after conventional and hyperfractionated radiotherapy. Radiother Oncol 47:137-143, 1998
118. Brizel DM, Prosnitz RG, Hunter S, et al: Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 58:1418-1423, 2004
119. Chan AW, Ancukiewicz M, Carballo N, et al: The role of postradiotherapy neck dissection in supraglottic carcinoma. Int J Radiat Oncol Biol Phys 50:367-375, 2001
120. Ellis ER, Mendenhall WM, Rao PV, et al: Incisional or excisional neck-node biopsy before definitive radiotherapy, alone or followed by neck dissection. Head Neck 13:177-183, 1991
121. Greven KM, Williams DW III, McGuirt WF Sr, et al: Serial positron emission tomography scans following radiation therapy of patients with head and neck cancer. Head Neck 23:942-946, 2001
122. Johnson CR, Silverman LN, Clay LB, et al: Radiotherapeutic management of bulky cervical lymphadenopathy in squamous cell carcinoma of the head and neck: Is postradiotherapy neck dissection necessary? Radiat Oncol Investig 6:52-57, 1998
123. Kligerman J, Olivatto LO, Lima RA, et al: Elective neck dissection in the treatment of T3/T4 N0 squamous cell carcinoma of the larynx. Am J Surg 170:436-439, 1995
124. Kutler DI, Patel SG, Shah JP: The role of neck dissection following definitive chemoradiation. Oncology (Williston Park) 18:993-998, 999, 1003-1004, 1007, 2004
125. Lavertu P, Adelstein DJ, Saxton JP, et al: Management of the neck in a randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer. Head Neck 19:559-566, 1997
126. Levendag P, Sessions R, Vikram B, et al: The problem of neck relapse in early stage supraglottic larynx cancer. Cancer 63:345-348, 1989
127. Levendag PC, Hoekstra CJ, Eijkenboom WM, et al: Supraglottic larynx cancer, T1-4 N0, treated by radical radiation therapy. Problem of neck relapse. Acta Oncol 27:253-260, 1988
128. Mabanta SR, Mendenhall WM, Stringer SP, et al: Salvage treatment for neck recurrence after irradiation alone for head and neck squamous cell carcinoma with clinically positive neck nodes. Head Neck 21:591-594, 1999
129. Mack Y, Parsons JT, Mendenhall WM, et al: Squamous cell carcinoma of the head and neck: Management after excisional biopsy of a solitary metastatic neck node. Int J Radiat Oncol Biol Phys 25:619-622, 1993
130. McHam SA, Adelstein DJ, Rybicki LA, et al: Who merits a neck dissection after definitive chemoradiotherapy for N2-N3 squamous cell head and neck cancer? Head Neck 25:791-798, 2003
131. Mendenhall WM, Million RR, Cassisi NJ: Squamous cell carcinoma of the head and neck treated with radiation therapy: The role of neck dissection for clinically positive neck nodes. Int J Radiat Oncol Biol Phys 12:733-740, 1986
132. Mendenhall WM, Parsons JT, Mancuso AA, et al: Definitive radiotherapy for T3 squamous cell carcinoma of the glottic larynx, J Clin Oncol 15:2394-2402, 1997
133. Mendenhall WM, Parsons JT, Stringer SP, et al: Squamous cell carcinoma of the head and neck treated with irradiation: Management of the neck. Semin Radiat Oncol 2:163-170, 1992
134. Mendenhall WM, Villaret DB, Amdur RJ, et al: Planned neck dissection after definitive radiotherapy for squamous cell carcinoma of the head and neck. Head Neck 24:1012-1018, 2002
135. Ojiri H, Mendenhall WM, Stringer SP, et al: Post-RT CT results as a predictive model for the necessity of planned post-RT neck dissection in patients with cervical metastatic disease from squamous cell carcinoma. Int J Radiat Oncol Biol Phys 52:420-428, 2002
136. Peters LJ, Weber RS, Morrison WH, et al: Neck surgery in patients with primary oropharyngeal cancer treated by radiotherapy. Head Neck 18:552-559, 1996
137. Redaelli de Zinis LO, Nicolai P, Tomenzoli D, et al: The distribution of lymph node metastases in supraglottic squamous cell carcinoma: Therapeutic implications. Head Neck 24:913-920, 2002
138. Sykes AJ, Slevin NJ, Gupta NK, et al: 331 cases of clinically node-negative supraglottic carcinoma of the larynx: A study of a modest size fixed field radiotherapy approach. Int J Radiat Oncol Biol Phys 46:1109-1115, 2000
139. Weber PC, Johnson JT, Myers EN: The impact of bilateral neck dissection on pattern of recurrence and survival in supraglottic carcinoma. Arch Otolaryngol Head Neck Surg 120:703-706, 1994
140. Wolf GT, Fisher SG: Effectiveness of salvage neck dissection for advanced regional metastases when induction chemotherapy and radiation are used for organ preservation. Laryngoscope 102:934-939, 1992
141. Wong RJ, Lin DT, Schoder H, et al: Diagnostic and prognostic value of [(18)F]fluorodeoxyglucose positron emission tomography for recurrent head and neck squamous cell carcinoma. J Clin Oncol 20:4199-4208, 2002
142. Yao M, Graham MM, Hoffman HT, et al: The role of post-radiation therapy FDG PET in prediction of necessity for post-radiation therapy neck dissection in locally advanced head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 59:1001-1010, 2004
143. Bernier J, Domenge C, Ozsahin M, et al: Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350:1945-1952, 2004
144. Cooper JS, Pajak TF, Forastiere AA, et al: Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350:1937-1944, 2004
145. Bachaud J-M, Cohen-Jonathan E, Alzieu C, et al: Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: Final report of the randomized trial. Int J Rad Oncol Biol Phys 36:999-1004, 1996
146. Alsner J, Sorensen SB, Overgaard J: TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck. Radiother Oncol 59:179-185, 2001
147. Benninger MS, Gillen J, Thieme P, et al: Factors associated with recurrence and voice quality following radiation therapy for T1 and T2 glottic carcinomas. Laryngoscope 104:294-298, 1994
148. Bradford CR, Zhu S, Wolf GT, et al: Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer: Department of Veterans Affairs Laryngeal Cancer Study Group. Otolaryngol Head Neck Surg 113:408-412, 1995
149. Browman GP, Mohide EA, Willan A, et al: Association between smoking during radiotherapy and prognosis in head and neck cancer: A follow-up study. Head Neck 24:1031-1037, 2002
150. Browman GP, Wong G, Hodson I, et al: Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer. N Engl J Med 328:159-163, 1993
151. Cabelguenne A, Blons H, de Waziers I, et al: p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: A prospective series. J Clin Oncol 18:1465-1473, 2000
152. Cho EI, Sasaki CT, Haffty BG: Prognostic significance of pretreatment hemoglobin for local control and overall survival in T1-T2N0 larynx cancer treated with external beam radiotherapy. Int J Radiat Oncol Biol Phys 58:1135-1140, 2004
153. Fein DA, Lee WR, Hanlon AL, et al: Pretreatment hemoglobin level influences local control and survival of T1-T2 squamous cell carcinomas of the glottic larynx. J Clin Oncol 13:2077-2083, 1995
154. Hermans R, Van den Bogaert W, Rijnders A, et al: Predicting the local outcome of glottic squamous cell carcinoma after definitive radiation therapy: Value of computed tomography-determined tumour parameters. Radiother Oncol 50:39-46, 1999
155. Hirvikoski P, Kumpulainen E, Virtaniemi J, et al: p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma. J Clin Oncol 15:3111-3120, 1997
156. Johansen LV, Grau C, Overgaard J: Laryngeal carcinoma: Multivariate analysis of prognostic factors in 1252 consecutive patients treated with primary radiotherapy. Acta Oncol 42:771-778, 2003
157. Kersh CR, Kelly MD, Hahn SS, et al: Early glottic carcinoma: Patterns and predictors of relapse after definitive radiotherapy. South Med J 83:374-378, 1990
158. Ljumanovic R, Langendijk JA, Schenk B, et al: Supraglottic carcinoma treated with curative radiation therapy: Identification of prognostic groups with MR imaging. Radiology 232:440-448, 2004
159. Mendenhall WM, Morris CG, Amdur RJ, et al: Parameters that predict local control after definitive radiotherapy for squamous cell carcinoma of the head and neck. Head Neck 25:535-542, 2003
160. Mendenhall WM, Parsons JT, Mancuso AA, et al: Radiotherapy for squamous cell carcinoma of the supraglottic larynx: An alternative to surgery. Head Neck 18:24-35, 1996
161. Murakami R, Baba Y, Furusawa M, et al: Early glottic squamous cell carcinoma: Predictive value of MR imaging for the rate of 5-year local control with radiation therapy. Acta Radiol 41:38-44, 2000
162. Osman I, Sherman E, Singh B, et al: Alteration of p53 pathway in squamous cell carcinoma of the head and neck: Impact on treatment outcome in patients treated with larynx preservation intent. J Clin Oncol 20:2980-2987, 2002
163. Pameijer FA, Mancuso AA, Mendenhall WM, et al: Can pretreatment computed tomography predict local control in T3 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy? Int J Radiat Oncol Biol Phys 37:1011-1021, 1997
164. Robbins KT, Davidson W, Peters LJ, et al: Conservation surgery for T2 and T3 carcinomas of the supraglottic larynx. Arch Otolaryngol Head Neck Surg 114:421-426, 1988
165. Stevens MH, Gardner JW, Parkin JL, et al: Head and neck cancer survival and life-style change. Arch Otolaryngol 109:746-749, 1983
166. Tarnawski R, Skladowski K, Maciejewski B: Prognostic value of hemoglobin concentration in radiotherapy for cancer of supraglottic larynx. Int J Radiat Oncol Biol Phys 38:1007-1011, 1997
167. Trask DK, Wolf GT, Bradford CR, et al: Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: Correlation with response to chemotherapy and organ preservation. Laryngoscope 112:638-644, 2002
168. Warde P, O'Sullivan B, Bristow RG, et al: T1/T2 glottic cancer managed by external beam radiotherapy: The influence of pretreatment hemoglobin on local control. Int J Radiat Oncol Biol Phys 41:347-353, 1998
169. Wolf GT, Makuch RW, Baker SR: Predictive factors for tumor response to
170. Spaulding MB, Fischer SG, Wolf GT: Tumor response, toxicity, and survival after neoadjuvant organ-preserving chemotherapy for advanced laryngeal carcinoma: The Department of Veterans Affairs Cooperative Laryngeal Cancer Study Group. J Clin Oncol 12:1592-1599, 1994
171. Truelson JM, Fisher SG, Beals TE, et al: DNA content and histologic growth pattern correlate with prognosis in patients with advanced squamous cell carcinoma of the larynx: The Department of Veterans Affairs Cooperative Laryngeal Cancer Study Group. Cancer 70:56-62, 1992
172. Gillespie MB, Bordsky MB, Day TA, et al: Swallowing-related quality of life after head and neck cancer treatment. Laryngoscope 114:1362-1367, 2004
173. Terrell JE, Ronis DL, Fowler KE, et al: Clinical predictors of quality of life in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 130:401-408, 2004
174. Eisbruch A, Lyden T, Bradford CR, et al: Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer. Int J Radiation Oncol Biol Phys 53:23-28, 2002
175. Nguyen NP, Molrz CC, Frank C, et al: Dysphagia following chemoradiation for locally advanced head and neck cancer. Ann Oncol 15:383-388, 2004
176. Smith RV, Kotz T, Beitler JJ, et al: Long-term swallowing problems after organ preservation therapy with concomitant radiation therapy and intravenous hydroxyurea: Initial results. Arch Otolaryngol Head Neck Surg 126:384-389, 2000
177. Eisbruch A, Schwartz M, Rasch C, et al: Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT? Int J Radiation Oncol Biol Phys 60:1425-1439, 2004
178. Smith RV, Goldman SY, Beitler JJ, et al: Decreased short- and long-term swallowing problems with altered radiotherapy dosing used in an organ-sparing protocol for advanced pharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 130:831-836, 2004
179. Fung K, Terrell JE: Outcomes research in head and neck cancer. ORL J Otorhinolaryngol Relat Spec 66:207-213, 2004