A rheological method to evaluate the physical stability of highly viscous pharmaceutical oil-in-water emulsions

Pharmaceutical Research

Volumn 23, Issue 8, 2006, Pages 1937-1947

  Masmoudi, Houda ^a   Piccerelle, Philippe ^a   Le Dréau, Yveline ^a   Kister, Jacky ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Aging; Emulsion; Freeze fracture electron microscopy; Rheology; Stability

Indexed keywords

CARBOMER; CETOSTEARYLIC ALCOHOL; EMULSIFYING AGENT; GERMALL 115; GLYCEROL; HUMECTANT; METHYL PARABEN; OIL; OLIVE OIL; POLYSORBATE 20; PROPYL PARABEN; SODIUM HYDROXIDE; SORBITAN OLEATE; SORBITAN STEARATE; WATER;

ARTICLE; DRUG FORMULATION; DRUG MANUFACTURE; DRUG STABILITY; DRUG STORAGE; ELECTRON MICROSCOPY; EMULSION; FLOW KINETICS; FREEZE FRACTURE ELECTRON MICROSCOPY; MEASUREMENT; OPTICAL CONTRAST PHASE MICROSCOPY; PARTICLE SIZE; PRIORITY JOURNAL; SHEAR STRESS; TECHNIQUE; VISCOSITY;

ADMINISTRATION, TOPICAL; ALGORITHMS; DRUG STABILITY; DRUG STORAGE; EMULSIONS; EXCIPIENTS; FREEZE FRACTURING; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON; MICROSCOPY, PHASE-CONTRAST; OILS; PARTICLE SIZE; POLYSORBATES; RHEOLOGY; SURFACE-ACTIVE AGENTS; VISCOSITY; WATER;

EID: 33746956685     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9038-x     Document Type: Article

References (38)

1. A.T. Florence and F. Rieg. L'instabilité des émulsions. In F. Puissieux and M. Seiller (eds.), Agents de Surface et Émulsions: Les Systèmes Dispersés I, Lavoisier, Tec & Doc, Paris (Galenica 5 vol. 5), 1983, pp. 321-342.
2. R. P. Borwankar, L. A. Lobo, and D. T. Wasan. Emulsion stability - kinetics of flocculation and coalescence. Colloids Surf. 69:135-146 (1992).
3. E. Dickinson. Les Colloïdes Alimentaires. Masson, Paris, 1992, pp. 85-121.
4. P. C. Hiemenz and R. Rajagopalan. Principles of Colloid and Surface Chemistry, 3rd ed., Dekker, New York, 1997.
5. J. Mewis and J. H. Macosko. Rheology: Principles, Measurements and Applications, VCH, New York, Chapter 10, 1994.
6. T. F. Tadros. Fundamental principles of emulsion rheology and their applications. Colloids Surf. A: Physicochem. Eng. Asp. 91:39-55 (1994).
7. R. Pal. Effect of droplet size on the rheology of emulsions. AIChE J. 42:3181-3190 (1996).
8. H. A Barnes. Rheology of emulsions - a review. Colloids Surf. A: Physicochem. Eng. Asp 91:89-95 (1994).
9. T. F. Tadros. Correlation of viscoelastic properties of stable and flocculated suspensions with their interparticle interactions. Adv. Colloid Interface Sci. 68:97-200 (1996).
10. T. G. Mason. New fundamental concepts in emulsion rheology. Curr. Opin. Colloid Interface Sci. 4:231-238 (1999).
11. R. Chanamai and D. J. McClements. Dependence of creaming and rheology of monodisperse oil-in-water emulsions on droplet size and concentration. Colloids Surf. A: Physicochem. Eng. Asp 172:79-86 (2000).
12. I. Terrisse, M. Seiller, A. Rabaron, J. L. Grossiord, A. Magnet, and C. Le Hen-Ferrenbach. Rheology: how to characterize and to predict the evolution of W/O/W multiple emulsions. Int. J. Cosmet. Sci. 15:53-62 (1993).
13. C. Py, J. Rouvière, P. Loll, M. C. Taelman, and T. F. Tadros. Investigation of multiple emulsion stability using rheological measurements. Colloids Surf. A: Physicochem. Eng. Asp 91:215-225 (1994).
14. S. Tamburic. The aging of polymer-stabilized creams: a rheological viewpoint. Cosmet. Toiletries 15:43-49 (2000).
15. M. Korhonen, L. Hellen, J. Hirvonen, and J. Yliruusi. Rheological properties of creams with four different surfactant combinations - effect of storage time and conditions. Int. J. Pharm. 221:187-196 (2001).
16. V. Kontogiorgos, C. G. Biliaderis, V. Kiosseoglou, and G. Doxastakis. Stability and rheology of egg-yolk-stabilized concentrated emulsions containing cereal β-glucans of varying molecular size. Food Hydrocoll. 18:987-998 (2004).
17. H. Masmoudi, Y. Le Dréau, P. Piccerelle, and J. Kister. The evaluation of cosmetic and pharmaceutical emulsions aging process using classical techniques and a new method: FTIR. Int. J. Pharm. 289:117-131 (2005).
18. J. Roussos. Formulation des émulsions. In F. Puissieux and M. Seiller (eds.), Agents de Surface et Émulsions: Les Systèmes Dispersés I, Lavoisier, Tec & Doc, Paris(Galenica 5 vol. 5), 1983, pp. 407-421.
19. J. Surh, E. A. Decker, and D. J. McClements. Properties and stability of oil-in-water emulsions stabilized by fish gelatine. Food Hydrocoll. 20:596-606 (2006).
20. V. André, N. Willenbacher, H. Debus, L. Börger, P. Fernandez, T. Frechen, and J. Rieger. Prediction of emulsion stability: facts and myth. Cosmetics and Toiletries Manufacture Worldwide 102-109 (2003).
21. D. Vasiljevic, J. Parojcic, M. Primorac, and G. Vuleta. An investigation into the characteristics and drug release properties of multiple W/O/W emulsion systems containing low concentration of lipophilic polymeric emulsifier. Int. J. Pharm. 309:171-177 (2006).
22. P. B. Laxton and J. C. Berg. Gel trapping of dense colloids. J. Colloid Interface Sci. 285:152-157 (2005).
23. S. Savic, G. Valuta, R. Daniels, and C. C. Mueller-Goymann. Colloidal microstructure of binary systems and model creams stabilized with an alkylpolyglucoside non-ionic emulsifier. Colloid. Polym. Sci. 283:439-451 (2005).
24. L. Baudonnet, J. L. Grossiord, and F. Rodriguez. Physicochemical characterization and in vitro release of salicylic acid from O/ W emulsions prepared with Montanov 68®: effect of formulation parameters. Drug Dev. Ind. Pharm. 30:975-984 (2004).
25. G. P. Roberts and H. A. Barnes. New measurements of the flow-curves for Carbopol dispersions without slip artefacts. Rheol. Acta 40:499-503 (2001).
26. H. Zhu, Y. D. Kim, and D. De Kee. Non-Newtonian fluids with a yield stress. J. Non-Newtonian Fluid Mech. 129:177-181 (2005).
27. T. F. Tadros. Application of rheology for assessment and prediction of the long-term physical stability of emulsions. Adv. Colloid Interface Sci. 108-109:227-258 (2004).
28. N. G. Diftis, C. G. Biliaderis, and V. D. Kiosseoglou. Rheological properties and stability of model salad dressing emulsions prepared with a dry-heated soybean protein isolate-dextran mixture. Food Hydrocoll. 19:1025-1031 (2005).
29. T. Ó. Thorgeirsdóttir, A. L. Kjøniksen, K. D. Knudsen, T. Kristmundsdóttir, and B. Nyström. Viscoelastic and structural properties of pharmaceutical hydrogels containing monocaprin. Eur. J. Pharm. Biopharm. 59:333-342 (2005).
30. A. Paraskevopoulou, V. Kiosseoglou, S. Alevisopoulos, and S. Kasapis. Small deformation properties of model salad dressings prepared with reduced cholesterol egg yolk. J. Texture Stud. 28:221-237 (1997).
31. N. Jager-Lézer, J. F. Tranchant, V. Alard, C. Vu, P. C. Tchoreloff, and J. L. Grossiord. Rheological analysis of highly concentrated W/O emulsions. Rheol. Acta 37:129-138 (1998).
32. G. K. Moates, A. D. Watson, and M. M. Robins. Creaming and oscillation rheology of weakly flocculated concentrated emulsions. Colloids Surf. A: Physicochem. Eng. Aspects 190:167-178 (2001).
33. J. Dubochet, J. Lepault, R. Freeman, J. A. Berriman, and J. C. Homo. Electron microscopy of frozen water and aqueous solutions. J. Microscopy. 128:219-237 (1982).
34. J. A. Zasadzinski and S. M. Bailey. Applications of freeze-fracture replication to problems in materials and colloid science. J. Electron Microsc. Tech. 13:309-334 (1989).
35. E. Dumay, C. Lambert, S. Funtenberger, and J. C. Cheftel. Effects of high pressure on the physico-chemical characteristics of dairy creams and model oil/water emulsions. Lebensmittel-Wissenschaft und-Technologie 29:606-625 (1996).
36. http://www.pharma.noveoinc.com/litterature.
37. T. Sanz Taberner, A. Martín-Villodre, J. M. Pla-Delfina, and J. V. Herráez. Consistency of Carbopol 971-P NF gels and influence of soluble and cross-linked PVP. Int. J. Pharm. 233:43-50 (2002).
38. R. Barreiro-Iglesias, C. Alvarez-Lorenzo, and A. Concheiro. Poly(acrylic acid) microgels (carbopol® 934)/surfactant interactions in aqueous media: Part I: Nonionic surfactants. Int. J. Pharm. 258:165-177 (2003).