Are anti-cyclic citrullinated peptide antibodies pathogenic in rheumatoid arthritis?

Nature Clinical Practice Rheumatology

Volumn 2, Issue 8, 2006, Pages 400-401

  Holers, V Michael ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ARGININE DEIMINASE; AUTOANTIBODY; CD20 ANTIBODY; CITRULLINE; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; CYTOKINE; EPITOPE; FIBRINOGEN; FILAGGRIN; HLA ANTIGEN; MONOCLONAL ANTIBODY; RHEUMATOID FACTOR; TUMOR NECROSIS FACTOR;

ANTIBODY DETECTION; ANTIBODY SPECIFICITY; AUTOIMMUNITY; B LYMPHOCYTE; BLOOD SAMPLING; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMORAL IMMUNITY; LYMPHOCYTE DEPLETION; MOUSE; NEPHELOMETRY; NONHUMAN; PATHOGENESIS; PATHOGENICITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROKARYOTE; PROTEIN SYNTHESIS; REVIEW; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; SYMPTOM; WESTERN BLOTTING;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; HUMANS; PEPTIDES, CYCLIC;

EID: 33746944583     PISSN: 17458382     EISSN: 17458390     Source Type: Journal    
DOI: 10.1038/ncprheum0247     Document Type: Review

References (10)

1. Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423: 356-361
2. Edwards JCW et al. (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. NEJM 350: 2572-2581
3. Van Venrooij WJ and Pruijn GJM (2000) Citrullination: A small change for a protein with great consequences for rheumatoid arthritis. Arthritis Res 2: 249-251
4. Lee DM and Schur PH (2003) Clinical utility of the anti-CCP assay in patients with rheumatic diseases. Ann Rheum Dis 62: 870-874
5. Rantapaa Dahlqvist S et al. (2003) Antibodies against citrullinated peptides (CCP) predict the development of rheumatoid arthritis. Arthritis Rheum 48: 2741-2749
6. De Rycke L et al. (2005) Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity. Arthritis Rheum 52: 2323-2330
7. Van Gaalen FA et al. (2005) The devil in the details: The emerging role of anticitrulline autoimmunity in rheumatoid arthritis. J Immunol 175: 5575-5580
8. Kuhn KA et al. (2006) Antibodies to citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 116: 961-973
9. Rose NR and Bona C (1993) Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 14: 426-430
10. Choy EHS and Panayi GS (2001) Cytokine pathways and joint inflammation in rheumatoid arthritis. NEJM 344: 907-916