Cisplatin mediates selective downstream hydrolytic cleavage of Met-(Gly)n-His segments (n = 1,2) in methionine- and histidine-containing peptides: The role of ammine loss trans to the initial Pt-S(Met) anchor in facilitating amide hydrolysis

Journal of Inorganic Biochemistry

Volumn 100, Issue 9, 2006, Pages 1506-1513

  Hohage, Oliver ^a   Sheldrick, William S ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Cisplatin; Complex formation; Histidine; Methionine; Peptide cleavage

Indexed keywords

ACETIC ACID; ACETYLGLYCYLMETHIONYLGLYCYLHISTIDYLGLYCINE HYDROXIDE; ACETYLMETHIONYLGLYCYLGLYCYLHISTIDYLGLYCINE HYDROXIDE; ACETYLMETHIONYLGLYCYLHISTIDYLGLYCYLGLYCINE HYDROXIDE; AMIDE; ANTINEOPLASTIC AGENT; CHELATING AGENT; CISPLATIN; HISTIDINE; IMIDAZOLE; METHIONINE; PENTAPEPTIDE; PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL BOND; COMPLEX FORMATION; DOWNSTREAM PROCESSING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIGAND BINDING; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PH; PROTEIN DEGRADATION; REACTION ANALYSIS;

AMIDES; AMINO ACID SEQUENCE; CISPLATIN; GLYCINE; HISTIDINE; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; METHIONINE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; ORGANOPLATINUM COMPOUNDS; PEPTIDES; PLATINUM;

EID: 33746925628     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2006.03.017     Document Type: Article

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