Homologous substitution of ACE C-domain regions with N-domain sequences: Effect on processing, shedding, and catalytic properties

Biological Chemistry

Volumn 387, Issue 8, 2006, Pages 1043-1051

  Woodman, Zenda L ^a   Schwager, Sylva L U ^a   Redelinghuys, Pierre ^a   Chubb, Anthony J ^a,c   Van Der Merwe, Elizabeth L ^a   Ehlers, Mario R W ^b   Sturrock, Edward D ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b Pacific Biometrics Inc   (United States)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Cooperativity; Domain selectivity; Proteolytic cleavage; Sheddase

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME C; ANGIOTENSIN CONVERTING ENZYME N; CHIMERIC PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE; ISOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL SURFACE; CHO CELL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; SEQUENCE HOMOLOGY; SOMATIC CELL; SUBSTITUTION REACTION; TESTIS;

ANIMALS; CATALYSIS; CATALYTIC DOMAIN; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; ISOENZYMES; KINETICS; MALE; PEPTIDYL-DIPEPTIDASE A; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TESTIS;

CRICETULUS GRISEUS;

EID: 33746922423     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2006.129     Document Type: Article

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