Endostatin inhibits VEGF-A induced osteoclastic bone resorption in vitro

BMC Musculoskeletal Disorders

Volumn 7, Issue , 2006, Pages

  Sipola, Annina ^a   Nelo, Katri ^a   Hautala, Timo ^a   Ilvesaro, Joanna ^a   Tuukkanen, Juha ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; COLLAGEN TYPE 18; ENDOSTATIN; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASEMENT MEMBRANE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG INHIBITION; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; RAT; STAINING;

ACID PHOSPHATASE; ANIMALS; BONE AND BONES; BONE DEVELOPMENT; BONE RESORPTION; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE XVIII; ENDOSTATINS; ISOENZYMES; OSTEOCLASTS; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33746913951     PISSN: 14712474     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-7-56     Document Type: Article

References (41)

1. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N: VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999, 5:623-628.
2. Olsen BR, Reginato AM, Wang W: Bone development. Annu Rev Cell Dev Biol 2000, 16:191-220.
3. Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, Henriksen K, Lenhard T, Foged NT, Werb Z, Delaisse JM: Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol 2000, 151:879-889.
4. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A: High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993, 72:835-846.
5. Clauss M, Weich H, Breier G, Knies U, Rockl W, Waltenberger J, Risau W: The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem 1996, 271:17629-17634.
6. Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marme D: Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 1996, 87:3336-3343.
7. Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M: Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci U S A 1998, 95:9349-9354.
8. Niida S, Kaku M, Amano H, Yoshida H, Kataoka H, Nishikawa S, Tanne K, Maeda N, Nishikawa S, Kodama H: Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med 1999, 190:293-298.
9. Harada S, Nagy JA, Sullivan KA, Thomas KA, Endo N, Rodan GA, Rodan SB: Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J Clin Invest 1994, 93:2490-2496.
10. Harada S, Rodan SB, Rodan GA: Expression and regulation of vascular endothelial growth factor in osteoblasts. Clin Orthop Relat Res 1995:76-80.
11. Nakagawa M, Kaneda T, Arakawa T, Morita S, Sato T, Yomada T, Hanada K, Kumegawa M, Hakeda Y: Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett 2000, 473:161-164.
12. Aoyama J, Tanaka E, Miyauchi M, Takata T, Hanaoka K, Hattori Y, Sasaki A, Watanabe M, Tanne K: Immunolocalization of vascular endothelial growth factor in rat condylar cartilage during postnatal development. Histochem Cell Biol 2004, 122:35-40.
13. Zelzer E, McLean W, Ng YS, Fukai N, Reginato AM, Lovejoy S, D'Amore PA, Olsen BR: Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development 2002, 129:1893-1904.
14. Tarkka T, Sipola A, Jamsa T, Soini Y, Yla-Herttuala S, Tuukkanen J, Hautala T: Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues. J Gene Med 2003, 5:560-566.
15. Rehn M, Veikkola T, Kukk-Valdre E, Nakamura H, Ilmonen M, Lombardo C, Pihlajaniemi T, Alitalo K, Vuori K: Interaction of endostatin with integrins implicated in angiogenesis. Proc Natl Acad Sci U S A 2001, 98:1024-1029.
16. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997, 88:277-285.
17. Chuntharapai A, Bodary S, Horton M, Kim KJ: Blocking monoclonal antibodies to alpha V beta 3 integrin: a unique epitope of alpha V beta 3 integrin is present on human osteoclasts. Exp Cell Res 1993, 205:345-352.
18. Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M: The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 1989, 109:1817-1826.
19. Duong LT, Lakkakorpi P, Nakamura I, Rodan GA: Integrins and signaling in osteoclast function. Matrix Biol 2000, 19:97-105.
20. Boyde A, Ali NN, Jones SJ: Resorption of dentine by isolated osteoclasts in vitro. Br Dent J 1984, 156:216-220.
21. Chambers TJ, Revell PA, Fuller K, Athanasou NA: Resorption of bone by isolated rabbit osteoclasts. J Cell Sci 1984, 66:383-399.
22. Lakkakorpi P, Tuukkanen J, Hentunen T, Jarvelin K, Vaananen K: Organization of osteoclast microfilaments during the attachment to bone surface in vitro. J Bone Miner Res 1989, 4:817-825.
23. Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T: Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 1988, 122:1373-1382.
24. Minkin C: Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif Tissue Int 1982, 34:285-290.
25. Villars F, Bordenave L, Bareille R, Amedee J: Effect of human endothelial cells on human bone marrow stromal cell phenotype: role of VEGF? J Cell Biochem 2000, 79:672-685.
26. Henriksen K, Karsdal M, Delaisse JM, Engsig MT: RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism. J Biol Chem 2003, 278:48745-48753.
27. Marks SCJ, Lane PW: Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse. J Hered 1976, 67:11-18.
28. Marks SCJ: Morphological evidence of reduced bone resorption in osteopetrotic (op) mice. Am J Anat 1982, 163:157-167.
29. Wiktor-Jedrzejczak WW, Ahmed A, Szczylik C, Skelly RR: Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation. J Exp Med 1982, 156:1516-1527.
30. Sundquist KT, Cecchini MG, Marks SCJ: Colony-stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) mice. Bone 1995, 16:39.
31. Kodama H, Nose M, Niida S, Yamasaki A: Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells. J Exp Med 1991, 173:1291-1294.
32. Kodama H, Yamasaki A, Nose M, Niida S, Ohgame Y, Abe M, Kumegawa M, Suda T: Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor. J Exp Med 1991, 173:269-272.
33. Felix R, Cecchini MG, Fleisch H: Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse. Endocrinology 1990, 127:2592-2594.
34. Pufe T, Mentlein R, Tsokos M, Steven P, Varoga D, Goldring MB, Tillmann BN, Paulsen FP: VEGF expression in adult permanent thyroid cartilage: implications for lack of cartilage ossification. Bone 2004, 35:543-552.
35. Pufe T, Petersen WJ, Miosge N, Goldring MB, Mentlein R, Varoga DJ, Tillmann BN: Endostatin/collagen XVIII - an inhibitor of angiogenesis - is expressed in cartilage and fibrocartilage. Matrix Biol 2004, 23:267-276.
36. Sasaki T, Fukai N, Mann K, Gohring W, Olsen BR, Timpl R: Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin. EMBO J 1998, 17:4249-4256.
37. Feldman AL, Pak H, Yang JC, Alexander HRJ, Libutti SK: Serum endostatin levels are elevated in patients with soft tissue sarcoma. Cancer 2001, 91:1525-1529.
38. Shi W, Teschendorf C, Muzyczka N, Siemann DW: Adeno-associated virus-mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo. Cancer Gene Ther 2002, 9:513-521.
39. Calvo A, Feldman AL, Libutti SK, Green JE: Adenovirus-mediated endostatin delivery results in inhibition of mammary gland tumor growth in C3(1)/SV40 T-antigen transgenic mice. Cancer Res 2002, 62:3934-3938.
40. Indraccolo S, Gola E, Rosato A, Minuzzo S, Habeler W, Tisato V, Roni V, Esposito G, Morini M, Albini A, Noonan DM, Ferrantini M, Amadori A, Chieco-Bianchi L: Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells. Gene Ther 2002, 9:867-878.
41. Kucharz EJ, Gozdzik J, Kopec M, Kotulska A, Lewicki M, Pieczyrak R, Widuchowska M, Zakliczynska H, Szarzynska-Ruda M, Zycinska-Debska E: A single infusion of infliximab increases the serum endostatin level in patients with rheumatoid arthritis. Clin Exp Rheumatol 2003, 21:273-274.