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note
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See Supporting Information.
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33
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33746902651
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note
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The folded oligocholate resembles a unimolecular reversed micelle. The most "folding-friendly" solvents are nonpolar ones mixed with a small amount of a polar solvent. Because the interior of a folded conformer prefers polar molecules, microphase separation of solvents happens during folding. MeOH is completely miscible with EA but barely miscible with hexane. Therefore, demixing should be easier in MeOH/hexane/EA than in MeOH/EA.
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34
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0001315212
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2) are 14 (EA), 17 (water and THF), 18 (methanol and butanol), and 28 (DMSO). See: (a) Sandström, M.; Persson, I.; Persson, P. Acta Chem. Scand. 1990, 44, 653-675.
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36
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33746905757
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Unpublished work. Only 5% of water can be dissolved in MTHF/THF (2/1). We are currently investigating why folding is particularly difficult in aqueous mixtures
-
Zhao, Y.; Zhong, Z. Unpublished work. Only 5% of water can be dissolved in MTHF/THF (2/1). We are currently investigating why folding is particularly difficult in aqueous mixtures.
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Zhao, Y.1
Zhong, Z.2
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