Evaluation of the pharmacokinetic profile and analgesic efficacy of oral morphine after total hip arthroplasty

European Journal of Anaesthesiology

Volumn 23, Issue 9, 2006, Pages 748-754

  Manoir, B D ^a   Bourget, P ^b   Langlois, M ^c   Szekely, B ^d   Fischler, M ^d   Chauvin, M ^c   Paci, A ^b   Fletcher, D ^c,e  

^a Département d'Anesthésie Réanimation CHU Caen   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c RAYMOND POINCARÉ HOSPITAL   (France)

^d FOCH HOSPITAL   (France)

^e LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Analgesia, patient controlled; Analgesics, opioid, morphine; Bio availability; Drug administration routes, oral; Pain acute and postoperative; Postoperative period

Indexed keywords

MORPHINE SULFATE; PLACEBO;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; GENERAL ANESTHESIA; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; POSTANESTHESIA CARE; POSTOPERATIVE PAIN; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SEDATION; SIDE EFFECT; TOTAL HIP PROSTHESIS; URINE RETENTION; VISUAL ANALOG SCALE; VOMITING;

ADMINISTRATION, ORAL; ADULT; AGED; ANALGESICS, OPIOID; AREA UNDER CURVE; ARTHROPLASTY, REPLACEMENT, HIP; FEMALE; HUMANS; MALE; MIDDLE AGED; MORPHINE; PAIN, POSTOPERATIVE; PLACEBOS; POSTOPERATIVE PERIOD; TIME FACTORS;

EID: 33746905895     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S0265021506000731     Document Type: Article

References (35)

1. Ballantyne JC, Carr DB, deFerranti S et al. The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials. Anesth Analg 1998; 86: 598-612.
2. Jacox A, Carr DB, Mahrenholz DM, Ferrell BM. Cost considerations in patient-controlled analgesia. Pharmacoeconomics 1997; 12: 109-120.
3. Jakobi P, Weiner Z, Solt I et al. Oral analgesia in the treatment of post-Cesarean pain. Eur J Obstet Gyn R B 2000; 93: 61-64.
4. Monagle J, Molnar A, Shearer W. Oral medication for post-Caesarean analgesia. Aust NZ J Obstet Gyn 1998; 38: 169-171.
5. Flory DA, Fankhauser RA, McShane MA. Postoperative pain control in total joint arthroplasty: a prospective, randomized study of a fixed-dose, around-the-clock, oral regimen. Orthopedics 2001; 24: 243-246.
6. McCormack JP, Warriner CB, Levine M, Glick N. A comparison of regularly dosed oral morphine and on-demand intramuscular morphine in the treatment of postsurgical pain. Can J Anaesth 1993; 40: 819-824.
7. Slowey HF, Reynolds AD, Mapleson WW, Vickers MD. Effect of premedication with controlled-release oral morphine on postoperative pain. A comparison with intramuscular morphine. Anaesthesia 1985; 40: 438-440.
8. Banning AM, Schmidt JF, Chraemmer-Jorgensen B, Risbo A. Comparison of oral controlled release morphine and epidural morphine in the management of postoperative pain. Anesth Analg 1986; 65: 385-388.
9. Bourke M, Hayes A, Doyle M, McCarroll M. A comparison of regularly administered sustained release oral morphine with intramuscular morphine for control of postoperative pain. Anesth Analg 2000; 90: 427-430.
10. Cooper SA, Fitzmartin R, Slywka J et al. Analgesic efficacy and safety of two oral controlled-release morphine preparations in orthopedic postoperative pain. Adv Ther 1994; 11: 213-227.
11. Derbyshire DR, Bell A, Parry PA, Smith G. Morphine sulphate slow release. Comparison with i.m. morphine for postoperative analgesia. Br J Anaesth 1985; 57: 858-865.
12. Fell D, Chmielewski A, Smith G. Postoperative analgesia with controlled-release morphine sulphate: comparison with intramuscular morphine. BMJ (Clin Res Ed) 1982; 285: 92-94.
13. Curtis GB, Johnson GH, Clark P et al. Relative potency of controlled-release oxycodone and controlled-release morphine in a postoperative pain model. Eur J Clin Pharmacol 1999; 55: 425-429.
14. Brahams D. Death of patient participating in trial of oral morphine for relief of postoperative pain. Lancet 1984; 1: 1083-1084.
15. Striebel HW, Scheitza W, Philippi W, Behrens U, Toussaint S. Quantifying oral analgesic consumption using a novel method and comparison with patient-controlled intravenous analgesic consumption. Anesth Analg 1998; 86: 1051-1053.
16. Striebel HW, Romer M, Kopf A, Schwagmeier R. Patient controlled oral analgesia with morphine. Can J Anaesth 1996; 43: 749-753.
17. Fletcher D, Zetlaoui P, Monin S, Bombart M, Samii K. Influence of timing on the analgesic effect of intravenous ketorolac after orthopedic surgery. Pain 1995; 61: 291-297.
18. Bourget P, Lesne-Hulin A, Quinquis-Desmaris V. Study of the bioequivalence of two controlled-release formulations of morphine. Int J Clin Pharm Th 1995; 33: 588-594.
19. Bourget P, Delouis JM. Review of a technique for the estimation of area under the concentration curve in pharmacokinetic analysis. Therapie 1993; 48: 1-5.
20. Yamaoka K, Nakagawa T, Uno T. Statistical moments in pharmacokinetics. J Pharmacokinet Biop 1978; 6: 547-558.
21. Woodhouse A, Hobbes AF, Mather LE, Gibson M. A comparison of morphine, pethidine and fentanyl in the postsurgical patient-controlled analgesia environment. Pain 1996; 64: 115-121.
22. Woodhouse A, Ward ME, Mather LE. Intra-subject variability in post-operative patient-controlled analgesia (PCA): is the patient equally satisfied with morphine, pethidine and fentanyl? Pain 1999; 80: 545-553.
23. Dahlstrom B, Tamsen A, Paalzow L, Hartvig P. Patient-controlled analgesic therapy. Part IV: Pharmacokinetics and analgesic plasma concentrations of morphine. Clin Pharmacokinet 1982; 7: 266-279.
24. Graves DA, Arrigo JM, Foster TS, Baumann TJ, Batenhorst RL. Relationship between plasma morphine concentrations and pharmacologic effects in postoperative patients using patient-controlled analgesia. Clin Pharmacol 1985; 4: 41-47.
25. Yuan CS, Foss JF, O'Connor M, Roizen MF, Moss J. Effects of low-dose morphine on gastric emptying in healthy volunteers. J Clin Pharmacol 1998; 38: 1017-1020.
26. Elfant AB, Levine SM, Peikin SR et al. Bioavailability of medication delivered via nasogastric tube is decreased in the immediate postoperative period. Am J Surg 1995; 169: 430-432.
27. Lotsch J, Geisslinger G. Morphine-6-glucuronide: an analgesic of the future? Clin Pharmacokinet 2001; 40: 485-499.
28. Ellison NM, Lewis GO. Plasma concentrations following single doses of morphine sulfate in oral solution and rectal suppository. Clin Pharmacol 1984; 3: 614-617.
29. Hoskin PJ, Hanks GW, Aherne GW et al. The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers. Br J Clin Pharmacol 1989; 27: 499-505.
30. Westerling D, Frigren L, Hoglund P. Morphine pharmacokinetics and effects on salivation and continuous reaction times in healthy volunteers. Ther Drug Monit 1993; 15: 364-374.
31. Fisher AP, Fung C, Hanna M. Serum morphine concentrations after buccal and intramuscular morphine administration. Br J Clin Pharmacol 1987; 24: 685-687.
32. Sawe J. High-dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral treatment. Clin Pharmacokinet 1986; 11: 87-106.
33. Sawe J, Dahlstrom B, Paalzow L, Rane A. Morphine kinetics in cancer patients. Clin Pharmacol Ther 1981; 30: 629-635.
34. Holte K, Kehlet H. Prevention of postoperative ileus. Minerva Anestesiol 2002; 68: 152-156.
35. Shelly MP, Taylor BL, Quinn KG, Park GR. The influence of anaesthetic technique on metabolism of oral morphine. Anaesthesia 1988; 43: 733-737.