Meconium and neurotoxicants: Searching for a prenatal exposure timing

Archives of Disease in Childhood

Volumn 91, Issue 8, 2006, Pages 642-646

  Ortega Garcia J A ^a   Carrizo Gallardo, D ^b   Ferris I Tortajada, J ^c   Garcia M M P ^c   Grimalt, J O ^b  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

^b DEPARTMENT OF ENVIRONMENTAL CHEMISTRY   (Spain)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CHLORPHENOTANE; HEXACHLOROBENZENE; HEXACHLOROCYCLOHEXANE; NEUROTOXIN; PENTACHLOROBENZENE; POLYCHLORINATED BIPHENYL;

APGAR SCORE; ARTICLE; CONTROLLED STUDY; FECES ANALYSIS; GAS CHROMATOGRAPHY; GESTATIONAL AGE; HUMAN; HUMAN EXPERIMENT; MECONIUM; NEUROTOXICITY; NEWBORN; PRENATAL EXPOSURE; PRIORITY JOURNAL; UMBILICAL CORD BLOOD;

ADULT; FEMALE; FETAL BLOOD; HAZARDOUS SUBSTANCES; HUMANS; HYDROCARBONS, CHLORINATED; INFANT, NEWBORN; MECONIUM; NERVOUS SYSTEM DISEASES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 33746903537     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.2005.084129     Document Type: Article

References (21)

1. Grandjean P, White R. Neurodevelopmental disorder's. In: Tamburlini G, von Ehrenstein OS, Bertollini R, eds. Children's health and environment: a review of evidence. Copenhagen: WHO, Regional Office for Europe, 2002:66-78.
2. Rice D, Barone S. Critical periods of vulnerability for the developing nervous system: evidence from human and animal models. Environ Health Perspect 2000;108:511-33.
3. Finkelstein Y, Markowitz ME, Rosen JF. Low-level lead- induced neurotoxicity in children: an update on central nervous system effects. Brain Res Brain Res Rev 1998;27:168-76.
4. Subcommittee on Reproductive and Neurodevelopment Toxicology Committee on Biological Markers. Biologic markers in reproductive toxicology. Washington, DC: National Academy Press, 1989.
5. Ortega García JA, Carrizo Gallardo D, Ferrís i Tortajada J, et al. Meconio y exposición prenatal a neurotóxicos. Rev Esp Pediatr 2004;60:291-6.
6. Weaver LT, Lucas A. Development of bowel habit in preterm infants. Arch Dis Child 1993;68:317-20.
7. Kaapa P, Kytola J, Soukka H, et al. Human meconium has potent antioxidative properties. Biol Neonate 1997;72:71-5.
8. Terasaka D, Clark DA, Singh BN, et al. Free fatty acids of human meconium. Biol Neonate 1986;50:16-20.
9. Ramon y Cajal CL, Martinez RO. Defecation in utero: a physiologic fetal function. Am J Obstet Gynecol 2003;188:153-6.
10. AMAP 2004. Arctic Monitoring and Assessment Programme. Oslo: AMAP Secretariat. Available:http://www.amap.no (accessed 1 August 2005).
11. Callahan CM, Grant TM, Phipps P, et al. Measurement of gestational cocaine exposure: sensitivity of infant's hair, meconium and urine. J Pediatr 1992;120:763-8.
12. Ostrea EM Jr, Knapp DK, Tannenbaum L, et al. Estimates of illicit drug use during pregnancy by maternal interview, hair analysis, and meconium analysis. J Pediatr 2001;138:344-8.
13. Ostrea EM Jr, Romero A, Knapp DK, et al. Postmortem drug analysis of meconium in early-gestation human fetuses exposed to cocaine: clinical implications. J Pediatr 1994;124:477-9.
14. Ryan RM, Wagner CL, Schultz JM, et al. Meconium analysis for improved identification or infants exposed to cocaine in utero. J Pediatr 1994;125:435-40.
15. Bar-Oz B, Klein J, Karaskov T, et al. Comparison of meconium and neonatal hair analysis for detection of gestational exposure to drugs of abuse. Arch Dis Child Fetal Neonatal Ed 2003;88:F98-100.
16. Ostrea EM, Brady MJ, Parks PM, et al. Drug screening of meconium in infants of drug dependent mothers: an alternative to urine screening. J Pediatr 1989;115:474-7.
17. Ostrea EM Jr. Testing of exposure to illicit drugs and other agents in the neonate: a review of laboratory methods and the role of meconium analysis. Curr Probl Pediatr 1999;29:37-56.
18. Samperiz S, Millet V, Arditti J, et al. Value of toxicological research in newborn infants of addicted mothers by the study of several samples (urine, meconium, hair). Arch Pediatr 1996;3:440-4.
19. Ostrea EM Jr, Morales V, Ngoumgna E, et al. Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. Neurotoxicology 2002;23:329-39.
20. Ostrea EM, Knapp DK, Tannenbaum L, et al. Serial meconium drug analysis can estimate the chronology and degree of the infant's in utero drug exposure. Pediatr Res 1993;33:229A.
21. INMA Network. Environment and childhood. Available at: http://www.infanciaymedioambiente.org (accessed June 2005).