Intrathecal bupivacaine protects against extension of lesions in an acute contusive spinal cord injury model

European Journal of Anaesthesiology

Volumn 23, Issue 9, 2006, Pages 793-800

  Lopez, S ^a,b   Dadure, C ^a   Vergnes, C ^c   Capdevila, X ^a  

^a LAPEYRONIE HOSPITAL   (France)

^b UNIV MONTPELLIER   (France)

^c HÔPITAL ARNAUD DE VILLENEUVE   (France)

Author keywords

Anaesthetics local, bupivacaine; Injections spinal, intrathecal; Rat; Spinal cord injuries; Traumatic, neuroprotection

Indexed keywords

BUPIVACAINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER EMPTYING; CONTROLLED STUDY; CONTUSION; DRUG EFFICACY; EVOKED SOMATOSENSORY RESPONSE; HISTOPATHOLOGY; LATENT PERIOD; MALE; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; RAT; SPINAL CORD INJURY;

ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; DRUG ADMINISTRATION ROUTES; ELECTROPHYSIOLOGY; EVOKED POTENTIALS, SOMATOSENSORY; INJECTIONS, SPINAL; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TIME FACTORS; TREATMENT OUTCOME;

EID: 33746866340     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S0265021506000615     Document Type: Article

References (37)

1. National Spinal Cord Injury Statistical Center. Spinal cord injury: facts and figures at Glance. J Spinal Cord Med 2000; 23: 51-53.
2. Cifu DX, Huang ME, Kolakowsky-Hayner A, Seel RT. Age, outcome, and rehabilitation costs after paraplegia caused by traumatic injury of the thoracic spinal cord, conus medullaris, and cauda equina. J Neurotraum 1999; 16: 805-815.
3. Allen AR. Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report. JAMA 1911; 57: 878-880.
4. Wrathall JR, Pettegrew R, Harvey F. Spinal cord contusion in the rat: production of graded, reproducible injury groups. Exp Neurol 1985; 88: 108-122.
5. Bracken MB, Shepard MJ, Collins WF, Holdford T, Young W, Baskin DS. A randomised controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N Engl J Med 1990; 322: 1405-1411.
6. Bracken MB, Shepard MJ, Collins WF, Holdford T, Baskin DS, Eisenberg HM. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1 year follow-up data. J Neurosurg 1992; 76: 23-31.
7. Faden AL. Pharmacotherapy in spinal cord injury: a critical review of recent development. Clin Neuropharmacol 1987; 10: 193-204.
8. Gorio A, Di Guillo AM, Young W. GA1 effects on chemical, traumatic and peripheral nerve induces lesions to the spinal cord. In: Murray M, Goldberger ME, Gorio A, eds. Development and Spasticity of the Mammalian Spinal Cord. New York: Lipincott Publishers, 1986: 227-242.
9. McIntosh TK, Vink R, Soares H, Hayes R, Simon R. Effect of non-competitive blockade of N-methyl-D-aspartate receptors on the neurochemical sequelae of experimental brain injury. J Neurochem 1990; 55: 1170-1179.
10. Bracken MB, Shepard MJ, Holford TR et al. Administration of methylprednisolone for 24 or 48 hours or tirilazed mesylate for 48 hours in the treatment of acute spinal cord injury. JAMA 1997; 277(20): 1597-1604.
11. Breckwoldt WL, Genco CM, Connoly RJ, Cleveland RJ, Diehl JT. Spinal cord protection during aortic occlusion: efficacy of intrathecal tetracaine. Ann Thorac Surg 1991; 51: 959-963.
12. Wakamatsu H, Matsumoto M, Nakakimura K. The effect of moderate hypothermia and intrathecal tetracaine on glutamate concentrations of intrathecal dialysate and neurologic and histopathologic outcome in transient spinal cord ischemia in rabbits. Anesth Analg 1999; 88: 56-62.
13. Lopez S, Privat A, Bernard N, Ohanna F, Vergnes C, Capdevila X. Intrathecal bupivacaine protects against extension of lesions in an acute photochemical spinal cord injury model. Can J Anaesth 2004; 51: 364-372.
14. Gaviria M, Privat A, D'Arbigny P, Kamenka JM, Haton H, Ohanna F. Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats. Brain Res 2000; 874: 200-209.
15. Tarlov I. Spinal cord compression studies. III. Time limits for recovery after gradual compression in dogs. Arch Neurol 1954; 71: 588-597.
16. Rivlin AS, Tator CS. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 1977; 47: 577-581.
17. Gale K, Kerasidis H, Wrathall JR. Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment. Exp Neurol 1985; 88: 123-134.
18. Cameron T, Prado R, Watson BD, Gonzalez-Carvajal M, Holets VR. Photochemically induced cystic lesion in the rat spinal cord. I. Behavioral and morphological analysis. Exp Neurol 1990; 109: 214-223.
19. Mimata H, Satoh F, Tanigawa T, Nomura Y, Ogata J. Changes of rat urinary bladder during acute spinal cord injury. Urol Int 1993; 51: 89-93.
20. Baskin DS, Simpson RK. Corticomotor and somatosensory evoked potential evaluation of acute spinal cord injury in the rat. Neurosurgery 1987; 20: 871-877.
21. Pencalet JP, Ohanna F, Poulat P, Kamenka JM, Privat A. Thienylphencyclidine protection for the spinal cord of adult rats against extension of lesions secondary to a photochemical injury. J Neurosurg 1993; 78: 603-609.
22. Black P, Markowitz RS, Molt JT. Model of spinal cord injury: Part 3. Dynamic low technique. Neurosurgery 1988; 22: 51-60.
23. Bresnahan JC, King J, Martin G, Yashon D. A neuroanatomical analysis of spinal cord injury in the rhesus monkey (Macaca mulatta). J Neurol Sci 1976; 28: 521-542.
24. Noble LJ, Wrathall JR. Spinal cord contusion in the rat: morphometric analyses of alteration in the spinal cord. Exp Neurol 1985; 88: 135-149.
25. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotraum 1995; 12: 1-21.
26. Guha A, Tator CH. Acute cardiovascular effects of experimental spinal cord injury. J Traum 1988; 28: 481-490.
27. Van Steenberge A, Joss S. Anesthésie péridurale, caudale et rachidienne. In: Samii K, ed. Anesthésie Réanimation chirurgicale, 2nd edn. Paris: Flammarion Publishers, 1995: 528-553.
28. Kobrine A, Evans D, LeGrys D, Yaffe L, Bradley M. Effect of intravenous lidocaine on experimental spinal cord injury. J Neurosurg 1984; 60: 595-601.
29. Gimenez Y, Ribotta M, Privat A. Biological interventions for spinal cord injury. Curr Opin Neurol 1998; 11: 647-654.
30. Rossner KL, Freese KJ. Bupivacaine inhibition of L-type calcium current in ventricular cardiomyocytes of hamster. Anesthesiology 1997; 87: 926-934.
31. Sugiyama K, Muteki T. Local anesthetics depress the calcium current of rat sensory neurones in culture. Anesthesiology 1994; 80: 1369-1378.
32. Onisei AM, Rossner KL. Effects of bupivacaine on the L-Type calcium channel in rat anterior pituitary cells. ASA 2001; A-726.
33. 2+ channels? Br J Anaesth 1997; 78: 185-188.
34. Hall ED, Wolf DL. A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia. J Neurosurg 1986; 64: 951-961.
35. Mäkelä A, Kuusi T, Schröder T. Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. Scand J Clin Lab Inv 1997; 57: 401-407.
36. Crosby G. Local spinal cord blood flow and glucose utilization during spinal anesthesia with bupivacaine in conscious rats. Anesthesiology 1985; 63: 55-60.
37. Kuroda Y, Sakabe T, Nakakimura K et al. Epidural bupivacaine suppresses local glucose utilization in the spinal cord and brain of rats. Anesthesiology 1990; 73: 944-950.