Gender differences in lymphocyte populations, plasma HIV RNA levels, and disease progression in a cohort of children born to women infected with HIV

Pediatrics

Volumn 118, Issue 1, 2006, Pages 146-155

  Foca, Marc ^a,i   Moye, Jack ^b   Chu, Clara ^c   Matthews, Yvonne ^c   Rich, Ken ^d   Handelsman, Ed ^e   Luzuriaga, Katherine ^f   Paul, Mary ^g   Diaz, Clemente ^h,j   Pacheco Acosta, Edna ^j   Tuomala, Ruth ^k   Cooper, Ellen ^k   Mesthene, Donna ^k   LaRussa, Phil ^l   Higgins, Alice ^l   Landesman, Sheldon ^e   Handelsman, Edward ^e   Dennie, Ava ^e   Rich, Kenneth ^d   Turpin, Delmyra ^d   Shearer, William ^g   Pacheco, Susan ^g   Cooper, Norma ^g   Rosario, Joana ^m   Nugent, Robert ^b   Smeriglio, Vincent ⁿ   Davenny, Katherine ⁿ   Thompson, Bruce ^c   more..

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c Clinical Trials & Surveys Corp   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e STATE UNIVERSITY OF NEW YORK   (United States)

^f UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^g BAYLOR COLLEGE OF MEDICINE   (United States)

^h UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

ⁱ NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^j UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^k Boston/Worcester Site   (United States)

^l New York Presbyterian Hospital Columbia University Medical Center   (United States)

^m NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

ⁿ NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

more..

Author keywords

Gender; HIV

Indexed keywords

ANTIRETROVIRUS AGENT; VIRUS RNA; ZIDOVUDINE;

ARTICLE; BLOOD SALVAGE; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGICAL PARAMETERS; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MORTALITY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; SEX DIFFERENCE; SURVIVAL RATE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; DISEASE TRANSMISSION; ETHNIC GROUP; ETHNOLOGY; INFANT; LYMPHOCYTE COUNT; MULTICENTER STUDY; NEWBORN; PREGNANCY; PREGNANCY COMPLICATION; PRESCHOOL CHILD;

CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DISEASE PROGRESSION; DISEASE TRANSMISSION, VERTICAL; ETHNIC GROUPS; FEMALE; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MALE; MULTIVARIATE ANALYSIS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RNA, VIRAL; SEX FACTORS;

EID: 33746857806     PISSN: 00314005     EISSN: 02105721     Source Type: Journal    
DOI: 10.1542/peds.2005-0294     Document Type: Article

References (34)

1. + cell counts persist after HIV-1 infection: SEROCO Study Group. AIDS. 1997;11:1071-1073
2. Prins M, Robertson JR, Brettle RP, et al. Do gender differences in CD4 cell counts matter? AIDS. 1999;13:2361-2364
3. Anastos K, Gange SJ, Lau B, et al. Association of race and gender with HIV-1 RNA levels and immunologic progression. J Acquir Immune Defic Syndr. 2000;24:218-226
4. Sterling TR, Lyles CM, Vlahov D, Astemborski J, Margolick JB, Quinn TC. Sex differences in longitudinal human immunodeficiency virus type 1 RNA levels among seroconverters. J Infect Dis. 1999;180:666-672
5. Farzadegan H, Hoover DR, Astemborski J, et al. Sex differences in HIV-1 viral load and progression to AIDS. Lancet. 1998;352:1510-1514
6. Junghans C, Ledergerber B, Chan P, Weber R, Egger M. Sex differences in HIV-1 viral load and progression to AIDS: Swiss HIV Cohort Study. Lancet. 1999;353:589
7. Moore AL, Mocroft A, Madge S, et al. Gender differences in virologic response to treatment in an HIV-positive population: a cohort study. J Acquir Immune Defic Syndr. 2001;26:159-163
8. Moore AL, Sabin CA, Johnson MA, Phillips AN. Gender and clinical outcomes after starting highly active antiretroviral treatment: a cohort study. J Acquir Immune Defic Syndr. 2002;29:197-202
9. Moore AL, Kirk O, Johnson AM, et al. Virologic, immunologic, and clinical response to highly active antiretroviral therapy: the gender issue revisited. J Acquir Immune Defic Syndr. 2003;32:452-461
10. Maini MK, Gilson RJ, Chavda N, et al. Reference ranges and sources of variability of CD4 counts in HIV-seronegative women and men. Genitourin Med. 1996;72:27-31
11. Shearer WT, Rosenblatt HM, Gelman RS, et al. Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol. 2003;112:973-980
12. AIDS Clinical Trials Group. Immunology. Available at: http://aactg.s-3.com/immlab.htm. Accessed January 21, 2006
13. AIDS Clinical Trials Group. Virology. Available at: http://aactg.s-3.com/ virlab.htm. Accessed January 21, 2006
14. Centers for Disease Control and Prevention. 1994 revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR Recomm Rep. 1994;43(RR-12):1-10
15. Zeger SL, Liang KY. Longitudinal data analysis for discrete and continuous outcomes. Biometrics. 1986;42:121-130
16. Neu N, Leighty R, Adeniyi-Jones S, et al. Immune parameters and morbidity in hard drug and human immunodeficiency virus-exposed but uninfected infants. Pediatrics. 2004;113:1260-1266
17. Rudy BJ, Wilson CM, Durako S, Moscicki AB, Muenz L, Douglas SD. Peripheral blood lymphocyte subsets in adolescents: a longitudinal analysis from the REACH project. Clin Diagn Lab Immunol. 2002;9:959-965
18. Douglas SD, Rudy B, Muenz L, et al. Peripheral blood mononuclear cell markers in antiretroviral therapy-naive HIV-infected and high risk seronegative adolescents: Adolescent Medicine HIV/AIDS Research Network. AIDS. 1999;13:1629-1635
19. Evans JS, Nims T, Cooley J, et al. Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women. J Infect Dis. 1997;175:795-800
20. Lyles CM, Vlahov D, Farzadegan H, et al. Comparison of two measures of human immunodeficiency virus (HIV) type 1 load in HIV risk groups. J Clin Microbiol. 1998;36:3647-3652
21. Sterling TR, Vlahov D, Astemborski J, Hoover DR, Margolick JB, Quinn TC. Initial plasma HIV-1 RNA levels and progression to AIDS in women and men. N Engl J Med. 2001;344:720-725
22. Katzenstein DA, Hammer SM, Hughes MD, et al. The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter: AIDS Clinical Trials Group Study 175 Virology Study Team. N Engl J Med. 1996;335:1091-1098
23. Rezza G, Lepri AC, d'Arminio Monforte A, et al. Plasma viral load concentrations in women and men from different exposure categories and with known duration of HIV infection: I.CO.N.A. Study Group. J Acquir Immune Defic Syndr. 2000;25:56-62
24. Donnelly CA, Bartley LM, Ghani AC, et al. Gender difference in HIV-1 RNA viral loads. HIV Med. 2005;6:170-178
25. + T cell counts and HIV type 1 viral loads in untreated, infected adolescents: Adolescent Medicine HIV/AIDS Research Network. AIDS Res Hum Retroviruses. 2000;16:959-963
26. Napravnik S, Poole C, Thomas JC, Eron JJ Jr. Gender difference in HIV RNA levels: a meta-analysis of published studies. J Acquir Immune Defic Syndr. 2002;31:11-19
27. Nicastri E, Angeletti C, Palmisano L, et al. Gender differences in clinical progression of HIV-1-infected individuals during long-term highly active antiretroviral therapy. AIDS. 2005;19:577-583
28. European Collaborative Study. Are there gender and race differences in cellular immunity patterns over age in infected and uninfected children born to HIV-infected women? J Acquir Immune Defic Syndr. 2003;33:635-641
29. European Collaborative Study. Level and pattern of HIV-1 RNA viral load over age: differences between girls and boys? AIDS. 2002;16:97-104
30. Friedland GH, Saltzman B, Vileno J, Freeman K, Schrager LK, Klein RS. Survival differences in patients with AIDS. J Acquir Immune Defic Syndr. 1991;4:144-153
31. Santoro-Lopes G, Harrison LH, Moulton LH, et al. Gender and survival after AIDS in Rio de Janeiro, Brazil. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;19:403-407
32. Tu XM, Meng XL, Pagano M. Survival differences and trends in patients with AIDS in the United States. J Acquir Immune Defic Syndr. 1993;6:1150-1156
33. Morgello S, Mahboob R, Yakoushina T, Khan S, Hague K. Autopsy findings in a human immunodeficiency virus-infected population over 2 decades: influences of gender, ethnicity, risk factors, and time. Arch Pathol Lab Med. 2002;126:182-190
34. Shanker G, Sorci-Thomas M, Adams MR. Estrogen modulates the expression of tumor necrosis factor α mRNA in phorbol ester-stimulated human monocytic THP-1 cells. Lymphokine Cytokine Res. 1994;13:377-382