Antiproliferative effect of pentoxifylline on psoriatic and normal epidermis. In vitro and in vivo studies

Acta Dermato-Venereologica

Volumn 76, Issue 6, 1996, Pages 437-441

  Gilhar, A ^a   Grossman, N ^b   Kahanovicz, S ^c   Reuveni, H ^b   Cohen, S ^d   Eitan, A ^d  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c MEIR MEDICAL CENTER   (Israel)

^d TEVA PHARMACEUTICALS   (Israel)

Author keywords

Autoradiography; Nude mice; Tetradecanyl phorbol 13 acetate

Indexed keywords

BETAMETHASONE VALERATE; PENTOXIFYLLINE; PHORBOL ESTER;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PSORIASIS; SKIN GRAFT; TOPICAL DRUG ADMINISTRATION;

ADULT; AGED; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; CARCINOGENS; EPIDERMIS; FEMALE; HUMANS; MALE; MICE; MICE, NUDE; MIDDLE AGED; PENTOXIFYLLINE; PSORIASIS; TETRADECANOYLPHORBOL ACETATE; TRANSPLANTATION, HETEROLOGOUS; VASODILATOR AGENTS;

EID: 0029858804     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Ward A, Chissold SP. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 1987; 34: 50-97.
2. Josaki K, Contrino J, Kristie J, Krause P, Kreutzer DL. Pentoxifylline-induced modulation of human leukocyte function in vitro. Am J Pathol 1990; 136: 623-630.
3. Tilg H, Eibl B, Pichl M, Gachter A, Herolo M, Brankova J, et al. Immune response modulation by pentoxifylline. Transplantation 1993; 56: 196-201.
4. Berman B, Duncan R. Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminoglycan, and fibrinonectin production, and increases collagenase activity. J Invest Dermatol 1989; 92: 605-610.
5. Stephanovich V, Jarvis P, Grigoleit H-G. Effect of pentoxifylline on the cyclic AMP system in platelets. Med Welt 1975; 26: 2230-2233.
6. Barker JN. The pathophysiology of psoriasis. Lancet 1991; 338: 227-230.
7. Nickoloff BJ. The cytokine network in psoriasis. Arch Dermatol 1991; 127: 871-884.
8. Alegre ML, Gastaldello K, Abramowicz D, Kinnaert P, Vereerstraeten P, de Pauw L, et al. Evidence that pentoxifylline reduces antiCD3 monoclonal antibody-induced cytokine release syndrome. Transplantation 1991; 52: 674-679.
9. Prunieras M, Delescluse C, Bourin MC. Hyperplasia and tumor promotion. Int J Dermatol 1982; 21: 256-258.
10. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975; 6: 331-344.
11. Green H, Kehinde O, Thomas J. Growth of cultured human epidermal cells in multiple epithelia suitable for grafting. Proc Natl Acad Sci USA 1979; 75: 5665-5668.
12. McLane JA, Katz M, Abdelkader N. Effect of 1,25-dihydroxyvitamin D3 on human keratinocytes grown under different culture conditions. In Vitro Cell Dev Biol 1990; 26: 379-387.
13. Rheinwald JG. Methods for clonal and serial cultivation of normal human epidermal keratinocytes and mesothelial cells. In: Baserga R. ed. Cell growth and division: a practical approach. Oxford: IRL Press, 1989: 81-94.
14. Sun T-T, Green HG. Differentiation of the epidermal keratinocyte in cell culture: formation of the cornified envelope. Cell 1976; 9: 511-521.
15. Gilhar A, Pillar T, David M, Eidelman S. Melanocytes and Langerhans cells in aged versus young skin before and after transplantation onto nude mice. J Invest Dermatol 1991; 96: 210-214.
16. Gilhar A, Ish-Shalom S, Pillar T, Etzioni A, Silbermann M. Effect of antiinsulin-like growth factor 1 on epidermal proliferation of human skin transplanted onto nude mice treated with growth hormone. Endocrinology 1994; 124: 229-232.
17. Hill HR, Ungvustine NH, Newton JA, Shigeoka O, Morris E, Sacchi F. Correction of a developmental effect in neutrophil activation and movement. Am J Pathol 1987; 128: 307-314.
18. Sullivan GW, Carper HT, Novick WJ, Huh P-W, Mandell GL. Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor-alpha on neutrophil function by pentoxifylline. Infect Immunol 1988; 56: 1722-1729.
19. DeFraissinette AD, Berman B, Duncan MR, Lefevre L. Effects of pentoxifylline in interferon-gamma and tumor necrosis factor-alpha induction of intercellular adhesion molecule-I expression on human normal keratinocytes and Langerhans cells. Eur J Dermatol 1992; 2: 265-272.
20. Schwartz A, Krone CV, Trautinger F, Aragane Y, Neuner P, Luger TA, et al. Pentoxifylline suppresses irritant and contact hypersensitivity reactions. J Invest Dermatol 1993; 101: 549-552.
21. Fraki JE, Briggman RA, Lazarus GS. Uninvolved skin from psoriatic patients developed signs of involved psoriatic skin after being grafted onto nude mice. Science 1982; 215: 685-687.
22. Hegemann L, Mahrle G. Biochemical pharmacology of protein kinase C and its relevance for dermatology. In: Mukhtar H, ed. Pharmacology of the skin. Boca Raton: CRC Press, 1991: 357-368.
23. Koch F, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC, et al. Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 1990; 172: 1609-1614.
24. Kupfer TS. Production of cytokines by epithelial tissue: a new model for cutaneous inflammation. Am J Dermatopathol 1989; 11: 69-73.
25. Gomi T, Shiohara T, Munakata T, Imanishi K, Nagashima M. Interleukin-1 alpha, tumor necrosis factor-alpha and interferon-gamma in psoriasis. Arch Dermatol 1991; 127: 827-830.