Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1762, Issue 7, 2006, Pages 647-655

  Wilson, Samantha J ^a   Amsler, Kurt ^a   Hyink, Deborah P ^a   Li, Xiaohong ^a   Lu, Weining ^b   Zhou, Jing ^b   Burrow, Christopher R ^a   Wilson, Patricia D ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Dimerization; EGF receptor; PKD null mouse; Polarity; Renal development; Signal transduction; siRNA; Small molecule therapy; Tyrosine kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (2 BENZOTHIAZOLYL)THIOMETHYL 4 HYDROXY 3 METHOXYBENZYLIDENECYANOACETAMIDE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HERBIMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BASEMENT MEMBRANE; BIOASSAY; CELL MIGRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CYST; KIDNEY EPITHELIUM; KIDNEY POLYCYSTIC DISEASE; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

CELL MOVEMENT; CLONING, MOLECULAR; EPITHELIAL CELLS; HUMANS; IMMUNOBLOTTING; POLYCYSTIC KIDNEY DISEASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING;

EID: 33746845683     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2006.04.006     Document Type: Article

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