Serum leptin and cytokines in whole blood in relation to clinical and nutritional status in cystic fibrosis

Journal of Pediatric Gastroenterology and Nutrition

Volumn 43, Issue 2, 2006, Pages 228-233

  Schmitt Grohé, Sabina ^a,d   Hippe, Valerie ^a   Igel, Michael ^a   Von Bergmann, Klaus ^a   Posselt, Hans G ^b   Krahl, Andreas ^b   Smaczny, Christina ^b   Wagner, Thomas O F ^b   Nikolaizik, Wilfried ^c   Lentze, Michael J ^a   Zielen, Stefan ^b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Anorexia; Cystic fibrosis; Interleukin 8; Leptin; Tumor necrosis factor

Indexed keywords

CYTOKINE; INTERLEUKIN 8; LEPTIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CHEMOLUMINESCENCE; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATIONAL STUDY; CYSTIC FIBROSIS; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FORCED EXPIRATORY VOLUME; HEALTH STATUS; HOMOZYGOSITY; HUMAN; MALE; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; REGULATORY MECHANISM; SCORING SYSTEM; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; ANOREXIA; BODY MASS INDEX; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFANT; INTERLEUKIN-8; LEPTIN; LIPOPOLYSACCHARIDES; LUMINESCENCE; MALE; NUTRITIONAL STATUS; SEVERITY OF ILLNESS INDEX; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33746795962     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpg.0000228096.81831.a2     Document Type: Article

References (14)

1. Davis PB, Drumm M, Konstan MW. Cystic fibrosis. Am J Respir Crit Care Med 1996;154:1229-56.
2. Steinkamp G, Wiedemann B. Relationship between nutritional status and lung function in cystic fibrosis: cross sectional and longitudinal analyses from the German CF quality assurance (CFQA) project. Thorax 2002;57:596-601.
3. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-5.
4. Grunfeld C, Zhao, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters: a role for leptin in the anorexia of infection. J Clin Invest 1996;97:2152-7.
5. Di Franca M, Barbier D, Mege JL, et al. Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994;150:1453-5.
6. DeGodoy I, Donahoe M, Calhoun WJ, et al. Elevated TNF-α production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med 1996;153:633-7.
7. Arumugam R, LeBlanc A, Seilheimer DK, et al. Serum leptin and IGF-1 levels in cystic fibrosis. Endocr Res 1998;24:247-57.
8. Shwachman H, Kulczycki LL. Long-term study of one hundred five patients with cystic fibrosis. Am J Dis Child 1958;96:6-15.
9. Tartaglia L. The leptin receptor. J Biol Chem 1997;272:6093-6.
10. Schmitt-Grohé S, Naujoks C, Bargon J, et al. Interleukin-8 in whole blood and clinical status in cystic fibrosis. Cytokine 2005;29:18-23.
11. Torti FM, Dieckmann B, Beutler B, et al. A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science 1985;229:867-9.
12. Plata-Salaman CR, Borkoski JP. Interleukin-8 modulates feeding by direct action in the central nervous system. Am J Physiol 1993;265:R877-82.
13. Plata-Salaman CR, Borkoski JP. Chemokines/intercrines and central regulation of feeding. Am J Physiol 1994;266:R1711-5.
14. Yang ZJ, Koseki MM, Meguid JR, et al. Synergistic effect rhTNF-alpha and rhIL-1 alpha in inducing anorexia in rats. Am J Physiol 1994;267:R1056-64.