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Volumn 16, Issue 18, 2006, Pages 4879-4883

Discovery of a novel series of inhibitors of human cytomegalovirus primase

Author keywords

Cidofovir; CMV; Cytomegalovirus; Ganciclovir; Imidazolyl pyrimidine; Irreversible inhibitor; Radiolabeling; Tritiation; UL70 primase

Indexed keywords

ANTIVIRUS AGENT; CIDOFOVIR; ENZYME INHIBITOR; GANCICLOVIR; IMIDAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; VIRUS ENZYME;

EID: 33746785136     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.06.066     Document Type: Article
Times cited : (8)

References (30)
  • 1
    • 33746839830 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy for use against HIV.
  • 18
    • 33746821175 scopus 로고    scopus 로고
    • note
    • 50 values represent the concentration of test compound required to inhibit hCMV DNA replication by 50%.
  • 19
    • 33746835497 scopus 로고    scopus 로고
    • note
    • Some aspects of this work were presented at the 41st Interscience conference on Antimicrobial Agents and Chemotherapy, presentations 1672 and 1673. Chicago, IL, December 18th 2001 (posters).
  • 20
    • 33746845420 scopus 로고    scopus 로고
    • note
    • 50 values.
  • 22
    • 33746834246 scopus 로고    scopus 로고
    • Hanson, J. C. PCT Int. Appl. WO 91/01310.
  • 25
    • 33746798258 scopus 로고    scopus 로고
    • note
    • 99.9 determined to be the concentration of drug required to inhibit the hCMV replication by 99.9%.
  • 26
    • 33746860871 scopus 로고    scopus 로고
    • note
    • 99.9 values represent the amount of drug required to inhibit plaque formation by 99.9%.
  • 27
    • 33746848243 scopus 로고    scopus 로고
    • note
    • 50 value, concentration of compound that inhibited cell growth by 50%.
  • 28
    • 33746782269 scopus 로고    scopus 로고
    • note
    • 50) was calculated.
  • 29
    • 33746804315 scopus 로고    scopus 로고
    • American Radiolabeled Chemicals Inc., St. Louis, MO, performed the final tritiation step.
  • 30
    • 33746803903 scopus 로고    scopus 로고
    • note
    • Details of this and other experiments that characterize the exact cysteine residue on UL70 responsible for imidazole displacement will be published in due course.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.