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Volumn 3, Issue 5, 2005, Pages 815-823

Treatment strategies for highly treatment-experienced HIV-infected patients

Author keywords

Antiretroviral; HIV; Protease inhibitor; Resistance; Tipranavir

Indexed keywords

AMPRENAVIR; AMPRENAVIR PLUS LOPINAVIR PLUS RITONAVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIRETROVIRUS AGENT; ATAZANAVIR; DELAVIRDINE; EFAVIRENZ; ENFUVIRTIDE; INDINAVIR; LOPINAVIR; LOPINAVIR PLUS INDINAVIR PLUS RITONAVIR; LOPINAVIR PLUS RITONAVIR; LOPINAVIR PLUS RITONAVIR PLUS SAQUINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; TIPRANAVIR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 27544489336     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.3.5.815     Document Type: Review
Times cited : (6)

References (37)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella FJ Jr, Delaney KM, Moorman AC et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N. Engl. J. Med. 338, 853-860 (1998).
    • (1998) N. Engl. J. Med. , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 2
    • 27544475741 scopus 로고    scopus 로고
    • New insights into mechanisms of HIV-1 resistance to reverse transcriptase inhibitors
    • Presented at the 9th Conference on Retroviruses and Opportunistic Infections MA, USA
    • Mellors J. New insights into mechanisms of HIV-1 resistance to reverse transcriptase inhibitors. Presented at the 9th Conference on Retroviruses and Opportunistic Infections MA, USA (2002).
    • (2002)
    • Mellors, J.1
  • 3
    • 0036299468 scopus 로고    scopus 로고
    • Genetic mechanisms of resistance to NRTI and NNRTI
    • Soriano V, de Mendoza C. Genetic mechanisms of resistance to NRTI and NNRTI. HIV Clin. Trials 3, 237-248 (2002).
    • (2002) HIV Clin. Trials , vol.3 , pp. 237-248
    • Soriano, V.1    de Mendoza, C.2
  • 4
    • 0009811854 scopus 로고    scopus 로고
    • Kaletra (ABT-378/r) and efavirenz: One-year safety/efficacy evaluation and phenotypic breakpoints in multiple-PI-experienced patients
    • Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections IL, USA
    • Clumeck N, Brun S, Sylte J et al. Kaletra (ABT-378/r) and efavirenz: one-year safety/efficacy evaluation and phenotypic breakpoints in multiple-PI-experienced patients. Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. IL, USA (2001).
    • (2001)
    • Clumeck, N.1    Brun, S.2    Sylte, J.3
  • 5
    • 0036768328 scopus 로고    scopus 로고
    • Analysis of the virological response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir therapy
    • Kempf DJ, Isaacson JD, King MS et al. Analysis of the virological response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir therapy. Antivir. Ther. 7, 165-174 (2002).
    • (2002) Antivir. Ther. , vol.7 , pp. 165-174
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3
  • 6
    • 12244262297 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic analysis of lopinavir-ritonavir in combination with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively pretreated human immunodeficiency virus-infected patients
    • Hsu A, Isaacson J, Brun S et al. Pharmacokinetic-pharmacodynamic analysis of lopinavir-ritonavir in combination with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively pretreated human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 47, 350-359 (2003).
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 350-359
    • Hsu, A.1    Isaacson, J.2    Brun, S.3
  • 7
    • 0000817023 scopus 로고    scopus 로고
    • The Ctrough inhibitory quotient predicts virologic response to ABT-378/ritonavir (ABT-378/r) therapy in treatment-experienced patients
    • Hsu A, Granneman G, Kempf D et al. The Ctrough inhibitory quotient predicts virologic response to ABT-378/ritonavir (ABT-378/r) therapy in treatment-experienced patients. AIDS 14(Suppl. 4), S12 (2000).
    • (2000) AIDS , vol.14 , Issue.SUPPL. 4
    • Hsu, A.1    Granneman, G.2    Kempf, D.3
  • 8
    • 27544505801 scopus 로고    scopus 로고
    • Higher doses of lopinavir/ritonavir (LPV/r) in highly treatment-experienced, HIV-infected patients: 48-week safety/efficacy evaluation
    • Presented at the 15th International AIDS Conference. Bangkok, Thailand
    • Podzamczer D, Tressler R, Flexner C et al. Higher doses of lopinavir/ritonavir (LPV/r) in highly treatment-experienced, HIV-infected patients: 48-week safety/efficacy evaluation. Presented at the 15th International AIDS Conference. Bangkok, Thailand (2004).
    • (2004)
    • Podzamczer, D.1    Tressler, R.2    Flexner, C.3
  • 9
    • 27544489607 scopus 로고    scopus 로고
    • Lopinavir inhibitory quotient predicts virologic response in highly antiretroviral-experienced patients receiving high-dose lopinavir/ritonavir
    • Presented at the 11th Conference on Retroviruses and Opportunistic Infections. CA, USA
    • Bertz R, Li J, King M et al. Lopinavir inhibitory quotient predicts virologic response in highly antiretroviral-experienced patients receiving high-dose lopinavir/ritonavir. Presented at the 11th Conference on Retroviruses and Opportunistic Infections. CA, USA (2004).
    • (2004)
    • Bertz, R.1    Li, J.2    King, M.3
  • 10
    • 0027692502 scopus 로고
    • A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion
    • Wild C, Greenwell T, Matthews T. A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion. AIDS Res. Hum. Retroviruses 9, 1051-1053 (1993).
    • (1993) AIDS Res. Hum. Retroviruses , vol.9 , pp. 1051-1053
    • Wild, C.1    Greenwell, T.2    Matthews, T.3
  • 11
    • 0038576281 scopus 로고    scopus 로고
    • Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV Infection in North and South America
    • Lalezari JP, Henry K, O'Hearn M et al. Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV Infection in North and South America. N. Engl. J. Med. 348, 2175-2185 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2175-2185
    • Lalezari, J.P.1    Henry, K.2    O'Hearn, M.3
  • 12
    • 0037849954 scopus 로고    scopus 로고
    • Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia
    • Lazzarin A, Clotet B, Cooper D et al. Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. N. Engl. J. Med. 348, 2186-2195 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2186-2195
    • Lazzarin, A.1    Clotet, B.2    Cooper, D.3
  • 13
    • 0242705329 scopus 로고    scopus 로고
    • Enfuvirtide TORO studies: 48 week results confirm 24 week findings
    • Program and abstracts of the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment. Paris, France
    • Katlama C, Arastéh K, Clotet B et al. Enfuvirtide TORO studies: 48 week results confirm 24 week findings. Program and abstracts of the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment. Paris, France (2003).
    • (2003)
    • Katlama, C.1    Arastéh, K.2    Clotet, B.3
  • 14
    • 2442719637 scopus 로고    scopus 로고
    • Analysis of virological response of enfuvirtide in TORO: Implications for patient management
    • Montaner J, DeMasi R, Delehanty J et al. Analysis of virological response of enfuvirtide in TORO: implications for patient management. Antivir. Ther. 8(Suppl. 1), S212 (2003).
    • (2003) Antivir. Ther. , vol.8 , Issue.SUPPL. 1
    • Montaner, J.1    DeMasi, R.2    Delehanty, J.3
  • 15
    • 0141458274 scopus 로고    scopus 로고
    • Tipranavir: A protease inhibitor from a new class with distinct antiviral activity
    • Yeni P. Tipranavir: a protease inhibitor from a new class with distinct antiviral activity. J. Acquir. Immune Defic. Syndr. 34(Suppl. 1), S91-S94 (2003).
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.34 , Issue.SUPPL. 1
    • Yeni, P.1
  • 16
    • 1642418876 scopus 로고    scopus 로고
    • How flexible is tipranavir in complex with the HIV-1 protease active site?
    • Schake D. How flexible is tipranavir in complex with the HIV-1 protease active site? AIDS 18, 579-580 (2004).
    • (2004) AIDS , vol.18 , pp. 579-580
    • Schake, D.1
  • 17
    • 22644441098 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of tipranavir/ritonavir (TPV/r) alone or in combination with saquinavir (SQV), amprenavir (APV), or lopinavir: Interim analysis of BI 1182.51
    • Presented at the 15th International AIDS Conference. Bangkok, Thailand
    • Walmsley S, Leith J, Katlama C et al. Pharmacokinetics and safety of tipranavir/ritonavir (TPV/r) alone or in combination with saquinavir (SQV), amprenavir (APV), or lopinavir: interim analysis of BI 1182.51. Presented at the 15th International AIDS Conference. Bangkok, Thailand (2004).
    • (2004)
    • Walmsley, S.1    Leith, J.2    Katlama, C.3
  • 18
    • 22644445205 scopus 로고    scopus 로고
    • RESIST-1: A Phase 3, randomized, controlled, open-label, multicenter trial comparing tipranavir/ritonavir (TPV/r) to an optimized comparator protease inhibitor/r (CPI/r) regimen in antiretroviral-experienced patients: 24-week data
    • Presented at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington DC, USA
    • Hicks C. RESIST-1: a Phase 3, randomized, controlled, open-label, multicenter trial comparing tipranavir/ritonavir (TPV/r) to an optimized comparator protease inhibitor/r (CPI/r) regimen in antiretroviral-experienced patients: 24-week data. Presented at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington DC, USA (2004).
    • (2004)
    • Hicks, C.1
  • 19
    • 22644435810 scopus 로고    scopus 로고
    • 24-week data from RESIST 2: Phase 3 study of the efficacy and safety of either tipranavir/ritonavif (TPV/r) or an optimized ritonavir (RTV)-boosted standard-of-care (SOC) comparator PI (CPI) in a large randomized multicenter trial in treatment-experienced HIV+ patients
    • Proceedings of the 7th International Congress on Drug Therapy in HIV Infection. Glasgow, UK
    • Cahn P. 24-week data from RESIST 2: phase 3 study of the efficacy and safety of either tipranavir/ritonavif (TPV/r) or an optimized ritonavir (RTV)-boosted standard-of-care (SOC) comparator PI (CPI) in a large randomized multicenter trial in treatment-experienced HIV+ patients. Proceedings of the 7th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (2004).
    • (2004)
    • Cahn, P.1
  • 21
    • 27544498141 scopus 로고    scopus 로고
    • A genotypic score for efavirenz hypersusceptibility is associated with virologic response to EFV + indinavir ± abacavir in nucleoside-experienced patients
    • Presented at the 11th Conference on Retroviruses and Opportunistic Infections. CA, USA
    • Demeter L, DeGruttola V, Lustgarten S et al. A genotypic score for efavirenz hypersusceptibility is associated with virologic response to EFV + indinavir ± abacavir in nucleoside-experienced patients. Presented at the 11th Conference on Retroviruses and Opportunistic Infections. CA, USA (2004).
    • (2004)
    • Demeter, L.1    DeGruttola, V.2    Lustgarten, S.3
  • 22
    • 18344409610 scopus 로고    scopus 로고
    • The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: A prospect cohort analysis
    • Haubrich RH, Kemper CA, Hellmann NS et al. The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospect cohort analysis. AIDS 16, F33-F40 (2002).
    • (2002) AIDS , vol.16
    • Haubrich, R.H.1    Kemper, C.A.2    Hellmann, N.S.3
  • 23
    • 33444467485 scopus 로고    scopus 로고
    • The LOPSAQ study: 24 week analysis of the double protease inhibitor salvage regimen containing lopinavir (LPV/r) plus saquinavir without any additional antiretroviral (ART) therapy
    • Program and abstracts of the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment. Paris, France
    • Staszewski S, Dauer B, von Hentig N et al. The LOPSAQ study: 24 week analysis of the double protease inhibitor salvage regimen containing lopinavir (LPV/r) plus saquinavir without any additional antiretroviral (ART) therapy. Program and abstracts of the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment. Paris, France (2003).
    • (2003)
    • Staszewski, S.1    Dauer, B.2    von Hentig, N.3
  • 24
    • 13644252710 scopus 로고    scopus 로고
    • The LOPSAQ salvage study: 48 week analysis of the full cohort treated with lopinavir (LPV/r) plus saquinavir (SQV) without any additional antiretroviral (ART) therapy
    • Program and abstracts of the XV International AIDS Conference
    • Staszewski S, Dauer B, Carlebach A et al. The LOPSAQ salvage study: 48 week analysis of the full cohort treated with lopinavir (LPV/r) plus saquinavir (SQV) without any additional antiretroviral (ART) therapy. Program and abstracts of the XV International AIDS Conference (2004).
    • (2004)
    • Staszewski, S.1    Dauer, B.2    Carlebach, A.3
  • 25
    • 27544485947 scopus 로고    scopus 로고
    • Synergistic activity of lopinavir and saquinavir on protease inhibitor-resistant HIV-1
    • Presented at the 11th Conference of Retroviruses and Opportunistic Infections. CA, USA
    • Dam E, Rochas S, Faudon JL et al. Synergistic activity of lopinavir and saquinavir on protease inhibitor-resistant HIV-1. Presented at the 11th Conference of Retroviruses and Opportunistic Infections. CA, USA (2004).
    • (2004)
    • Dam, E.1    Rochas, S.2    Faudon, J.L.3
  • 26
    • 0035984802 scopus 로고    scopus 로고
    • In vitro antiviral interaction of lopinavir with other protease inhibitors
    • Molla A, Mo H, Vasavanonda S et al. In vitro antiviral interaction of lopinavir with other protease inhibitors. Antimicrob. Agents Chemother. 46, 2249-2253 (2002).
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2249-2253
    • Molla, A.1    Mo, H.2    Vasavanonda, S.3
  • 27
    • 0035808534 scopus 로고    scopus 로고
    • Multiple drug rescue therapy for HIV-infected individuals with prior virologic failure to multiple regimens
    • Montaner JSG, Harrigan PR, Jahnke N et al. Multiple drug rescue therapy for HIV-infected individuals with prior virologic failure to multiple regimens. AIDS 15, 61-69 (2001).
    • (2001) AIDS , vol.15 , pp. 61-69
    • Montaner, J.S.G.1    Harrigan, P.R.2    Jahnke, N.3
  • 28
    • 3343018343 scopus 로고    scopus 로고
    • Resistance and replication capacity assays: Clinical utility and interpretation
    • Haubrich RH. Resistance and replication capacity assays: clinical utility and interpretation. Top. HIV Med. 12, 52-56 (2004).
    • (2004) Top. HIV Med. , vol.12 , pp. 52-56
    • Haubrich, R.H.1
  • 29
    • 26144445611 scopus 로고    scopus 로고
    • Wide variation in Pro/Pol replication capacity in recently transmitted HIV-1 is conferred in part by protease inhibitor resistance mutations
    • Barbour JD, Wrin T, Hecht FM et al. Wide variation in Pro/Pol replication capacity in recently transmitted HIV-1 is conferred in part by protease inhibitor resistance mutations. Antivir. Ther. 8, S80 (2003).
    • (2003) Antivir. Ther. , vol.8
    • Barbour, J.D.1    Wrin, T.2    Hecht, F.M.3
  • 30
    • 0036838224 scopus 로고    scopus 로고
    • Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults
    • Barbour JD, Wrin T, Grant RM et al. Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults. J. Virol. 76, 11104-11112 (2002).
    • (2002) J. Virol. , vol.76 , pp. 11104-11112
    • Barbour, J.D.1    Wrin, T.2    Grant, R.M.3
  • 31
    • 0042431969 scopus 로고    scopus 로고
    • Structured treatment interruption in patients with multi-drug resistant human immunodeficiency virus
    • Lawrence J, Mayers DL, Hullsiek KH et al. Structured treatment interruption in patients with multi-drug resistant human immunodeficiency virus. N. Engl. J. Med. 349, 837-846 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , pp. 837-846
    • Lawrence, J.1    Mayers, D.L.2    Hullsiek, K.H.3
  • 32
    • 10744223335 scopus 로고    scopus 로고
    • Benefit of treatment interruption in HIV-infected patients with multiple therapeutic failures: A randomized controlled trial (ANRS 097)
    • Katlama C, Dominguez S, Gourlain K et al. Benefit of treatment interruption in HIV-infected patients with multiple therapeutic failures: a randomized controlled trial (ANRS 097). AIDS 18, 217-226 (2004).
    • (2004) AIDS , vol.18 , pp. 217-226
    • Katlama, C.1    Dominguez, S.2    Gourlain, K.3
  • 33
    • 0038234808 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adults infected with Human Immunodeficiency Virus Type 1: 2003 Recommendations of an International AIDS Society - USA Panel
    • Hirsch MS, Brun-Vezinet F, Bonaventura C et al. Antiretroviral drug resistance testing in adults infected with Human Immunodeficiency Virus Type 1: 2003 Recommendations of an International AIDS Society - USA Panel. Clin. Infect. Dis. 37, 113-128 (2003).
    • (2003) Clin. Infect. Dis. , vol.37 , pp. 113-128
    • Hirsch, M.S.1    Brun-Vezinet, F.2    Bonaventura, C.3
  • 34
    • 20544443261 scopus 로고    scopus 로고
    • Update of the drug resistance mutations in HIV-1: 2005
    • Johnson VA, Brun-Vezinet F, Bonaventura C et al. Update of the drug resistance mutations in HIV-1: 2005. Top. HIV Med. 13, 51-57 (2005).
    • (2005) Top. HIV Med. , vol.13 , pp. 51-57
    • Johnson, V.A.1    Brun-Vezinet, F.2    Bonaventura, C.3
  • 35
    • 15944425696 scopus 로고    scopus 로고
    • Relationship between drug resistance mutations, plasma viremia, and CD4 T-cell counts in patients with chronic HIV infection
    • de Mendoza C, Martin-Carbonero L, Gallego O et al. Relationship between drug resistance mutations, plasma viremia, and CD4 T-cell counts in patients with chronic HIV infection. J. Med. Virol. 76, 1-6 (2005).
    • (2005) J. Med. Virol. , vol.76 , pp. 1-6
    • de Mendoza, C.1    Martin-Carbonero, L.2    Gallego, O.3
  • 36
    • 4444282188 scopus 로고    scopus 로고
    • Effect of persistent moderate viremia on disease progression during HIV therapy
    • Raffanti S, Fusco JS, Sherril BH et al. Effect of persistent moderate viremia on disease progression during HIV therapy. J. Acquir. Immune Defic. Syndr. 37, 1147-1154 (2004).
    • (2004) J. Acquir. Immune Defic. Syndr. , vol.37 , pp. 1147-1154
    • Raffanti, S.1    Fusco, J.S.2    Sherril, B.H.3
  • 37
    • 3042740596 scopus 로고    scopus 로고
    • Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes
    • The PLATO Collaboration
    • The PLATO Collaboration. Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes. Lancet 364, 51-62 (2004).
    • (2004) Lancet , vol.364 , pp. 51-62


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