Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 2, 2006, Pages

  Larsen, Karl Otto ^a   Sjaastad, Ivar ^a,b   Svindland, Aud ^c   Krobert, Kurt A ^b   Skjønsberg, Ole Henning ^a   Christensen, Geir ^a,b  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c AKER UNIVERSITY HOSPITAL   (Norway)

Author keywords

Calcium; Diastole; Echocardiography

Indexed keywords

CALCIUM; PHOSPHOLAMBAN; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY BLOOD FLOW; ARTICLE; CALCIUM TRANSPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOSOL; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DOPPLER ECHOCARDIOGRAPHY; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE METABOLISM; HEART MUSCLE RELAXATION; HYPOXEMIA; LUNG ALVEOLUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; PULMONARY HYPERTENSION;

EID: 33746781664     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00862.2005     Document Type: Article

References (34)

1. Barbera JA, Peinado VI, and Santos S. Pulmonary hypertension in chronic obstructive pulmonary disease. Eur Respir J 21: 892-905, 2003.
2. Baum GL, Schwartz A, Llamas R, and Castillo C. Left ventricular function in chronic obstructive lung disease. N Engl J Med 285: 361-365, 1971.
3. Bers DM. Calcium and cardiac rhythms: physiological and pathophysiological. Circ Res 90: 14-17, 2002.
4. Bhargava V and Sunnerhagen KS. Left ventricular asynchrony in patients with pulmonary hypertension. J Appl Physiol 69: 517-522, 1990.
5. Boussuges A, Pinet C, Molenat F, Burnet H, Ambrosi P, Badier M, Sainty JM, and Orehek J. Left atrial and ventricular filling in chronic obstructive pulmonary disease. An echocardiographic and Doppler study. Am J Respir Crit Care Med 162: 670-675, 2000.
6. Braunwald E, Zipes DP, and Libby P. Heart Disease: A Textbook of Cardiovascular Medicine (6th ed). Philadelphia, PA: Saunders, 2001.
7. Danzi S and Klein I. Posttranscriptional regulation of myosin heavy chain expression in the heart by triiodothyronine. Am J Physiol Heart Circ Physiol 288: H455-H460, 2005.
8. Davis KL, Mehlhorn U, Laine GA, and Allen SJ. Myocardial edema, left ventricular function, and pulmonary hypertension. J Appl Physiol 78: 132-137, 1995.
9. Finsen AV, Christensen G, and Sjaastad I. Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse. J Appl Physiol 98: 680-689, 2005.
10. Finsen AV, Woldbaek PR, Li J, Wu J, Lyberg T, Tønnessen T, and Christensen G. Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling. Physiol Genomics 16: 301-308, 2004.
11. Fitzsimons DP, Patel JR, and Moss RL. Role of myosin heavy chain composition in kinetics of force development and relaxation in rat myocardium. J Physiol 513: 171-183, 1998.
12. Gomez A and Mink S. Increased left ventricular stiffness impairs filling in dogs with pulmonary emphysema in respiratory failure. J Clin Invest 78: 228-240, 1986.
13. Hasenfuss G and Schillinger W. Is modulation of sodium-calcium exchange a therapeutic option in heart failure? Circ Res 95: 225-227, 2004.
14. 2+-exchanger protein levels and diastolic function of failing human myocardium. Circulation 99: 641-648, 1999.
15. Hunter JJ, Tanaka N, Rockman HA, Ross J Jr, and Chien KR. Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J Biol Chem 270: 23173-23178, 1995.
16. Jones JE, Mendes L, Rudd MA, Russo G, Loscalzo J, and Zhang YY. Serial noninvasive assessment of progressive pulmonary hypertension in a rat model. Am J Physiol Heart Circ Physiol 283: H364-H371, 2002.
17. Kacimi R, Richalet JP, Corsin A, Abousahl I, and Crozatier B. Hypoxia-induced downregulation of β-adrenergic receptors in rat heart. J Appl Physiol 73: 1377-1382, 1992.
18. Kass DA, Bronzwaer JG, and Paulus WJ. What mechanisms underlie diastolic dysfunction in heart failure? Circ Res 94: 1533-1542, 2004.
19. Kimura Y, Kurzydlowski K, Tada M, and MacLennan DH. Phospholamban inhibitory function is activated by depolymerization. J Biol Chem 272: 15061-15064, 1997.
20. Kogler H, Hartmann O, Leineweber K, Nguyen van P, Schott P, Brodde OE, and Hasenfuss G. Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat. Circ Res 93: 230-237, 2003.
21. 7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution. Naunyn Schmiedebergs Arch Pharmacol 363: 620-632, 2001.
22. Levi M, Moons L, Bouche A, Shapiro SD, Collen D, and Carmeliet P. Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice. Circulation 103: 2014-2020, 2001.
23. MacLennan DH and Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4: 566-577, 2003.
24. Marangoni S, Scalvini S, Schena M, Vitacca M, Quadri A, and Levi G. Right ventricular diastolic function in chronic obstructive lung disease. Eur Respir J 5: 438-443, 1992.
25. Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, McGraw DW, Heist EK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, and Kranias EG. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circ Res 96: 756-766, 2005.
26. Prabhu SD. Cytokine-induced modulation of cardiac function. Circ Res 95: 1140-1153, 2004.
27. 16 phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity. Cardiovasc Res 53: 382-391, 2002.
28. Schafroth U, Godang K, Ueland T, and Bollerslev J. Leptin response to endogenous acute stress is independent of pituitary function. Eur J Endocrinol 145: 295-301, 2001.
29. Schena M, Clini E, Errera D, and Quadri A. Echo-Doppler evaluation of left ventricular impairment in chronic cor pulmonale. Chest 109: 1446-1451, 1996.
30. Seyfarth T, Gerbershagen HP, Giessler C, Leineweber K, Heinroth-Hoffmann I, Ponicke K, and Brodde OE. The cardiac β-adrenoceptor-G-protein(s)- adenylyl cyclase system in monocrotaline-treated rats. J Mol Cell Cardiol 32: 2315-2326, 2000.
31. Simmerman HK and Jones LR. Phospholamban: protein structure, mechanism of action, and role in cardiac function. Physiol Rev 78: 921-947, 1998.
32. Stessel H and Brunner F. Effect of endothelin antagonism on contractility, intracellular calcium regulation and calcium regulatory protein expression in right ventricular hypertrophy of the rat. Basic Clin Pharmacol Toxicol 94: 37-45, 2004.
33. 2+-exchanger in normal and detubulated rat cardiomyocytes. J Mol Cell Cardiol 35: 1325-1337, 2003.
34. Woldbaek PR, Hoen IB, Christensen G, and Tønnessen T. Gene expression of colony-stimulating factors and stem cell factor after myocardial infarction in the mouse. Acta Physiol Scand 175: 173-181, 2002.