Do young hepatocellular carcinoma patients have worse prognosis? The paradox of age as a prognostic factor in the survival of hepatocellular carcinoma patients

Liver International

Volumn 26, Issue 7, 2006, Pages 766-773

  Chen, Chien Hung ^a   Chang, Ting Tsung ^b   Cheng, Ken Sheng ^c   Su, Wei Wen ^d   Yang, Sheng Shun ^e   Lin, Hans Hsienhong ^f   Wu, Shun Sheng ^d   Lee, Chuan Mo ^g,h   Changchien, Chi Sin ^g,h   Chen, Chien Jen ⁱ   Sheu, Jin Chuan ^a   Chen, Ding Shinn ^a   Lu, Sheng Nan ^g,h  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^e TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^f BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^g CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^h CHANG GUNG UNIVERSITY   (Taiwan)

ⁱ NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

HBsAg; Hepatocellular carcinoma; Survival; Taiwan; Young

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA FETOPROTEIN; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; HEPATITIS B SURFACE ANTIGEN;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; RETROSPECTIVE STUDY; SEX DIFFERENCE; TUMOR VOLUME; VIRUS CARRIER;

ADULT; AGE FACTORS; AGED; BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; SEX FACTORS; SURVIVAL ANALYSIS; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 33746772000     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01309.x     Document Type: Article

References (32)

1. Parkin D M. Global cancer statistics in the year 2000. Lancet Oncol 2001; 2: 533-43.
2. Chen C H, Chen D S. Hepatocellular carcinoma: 30 years' experience in Taiwan. J Formos Med Assoc 1992; 91 (Suppl. 3): S187-202.
3. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-36.
4. Thomas M B, Zhu A X. Hepatocellular carcinoma: The need for progress. J Clin Oncol 2005; 23: 2892-9.
5. Lee C S, Sheu J C, Wang M, Hsu H C. Long-term outcome after surgery for asymptomatic small hepatocellular carcinoma. Br J Surg 1996; 83: 330-3.
6. Chen C H, Su W W, Yang S S, et al. Long-term trends and geographic variations in the survival rates of hepatocellular carcinoma: Analysis of 11,312 patients in Taiwan. J Gastroenterol Hepatol (in press).
7. Ebara M, Hatano R, Fukuda H, Yoshikawa M, Sugiura N, Saisho H. Natural course of small hepatocellular carcinoma with underlying cirrhosis. A study of 30 patients. Hepatogastroenterology 1998; 45 (Suppl. 3): 1214-20.
8. Trevisani F, D'intino P E, Grazi G L, et al. Clinical and pathologic features of hepatocellular carcinoma in young and older Italian patients. Cancer 1996; 77: 2223-32.
9. Furuta T, Kanematsu T, Matsumata T, et al. Clinicopathologic features of hepatocellular carcinoma in young patients. Cancer 1990; 66: 2395-8.
10. Lam C M, Chan A O, Ho P, et al. Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients -implications for screening. Aliment Pharmacol Ther 2004; 19: 771-7.
11. Kim J H, Choi M S, Lee H, et al. Clinical features and prognosis of hepatocellular carcinoma in young patients from a hepatitis B-endemic area. J Gastroenterol Hepatol 2006; 21: 588-94.
12. Hernandez-Castillo E, Mondragon-Sanchez R, Garduno-Lopez A L, et al. Hepatocellular carcinoma in the youth. A comparative analysis with hepatocellular carcinoma in adulthood. Hepatogastroenterology 2005; 52: 903-7.
13. Aramaki M, Kawano K, Sasaki A, et al. Hepatocellular carcinoma in young adults. Hepatogastroenterology 2005; 52: 1795-7.
14. Okuda K, Ohtsuki T, Obata H, et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer 1985; 56: 918-28.
15. The Cancer of the Liver Italian Program (CLIP) Investigators. A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients. Hepatology 1998; 28: 751-5.
16. Llovet J M, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362: 1907-17.
17. Kudo M, Chung H, Osaki Y. Prognostic staging system for hepatocellular carcinoma (CLIP score): Its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score). J Gastroenterol 2003; 38: 207-15.
18. Poon R T, Fan S T, Wong J. Selection criteria for hepatic resection in patients with large hepatocellular carcinoma larger than 10 cm in diameter. J Am Coll Surg 2002; 194: 592-602.
19. Zhou X D, Tang Z Y, Ma Z C, et al. Surgery for large primary liver cancer more than 10 cm in diameter. J Cancer Res Clin Oncol 2003; 129: 543-8.
20. Pawlik T M, Poon R T, Abdalla E K, et al. Critical appraisal of the clinical and pathologic predictors of survival after resection of large hepatocellular carcinoma. Arch Surg 2005; 140: 450-7.
21. Yeh C N, Lee W C, Chen M F. Hepatic resection and prognosis for patients with hepatocellular carcinoma larger than 10 cm: Two decades of experience at Chang Gung memorial hospital. Ann Surg Oncol 2003; 10: 1070-6.
22. Ng K K, Vauthey J N, Pawlik T M, et al. Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database. Ann Surg Oncol 2005; 12: 364-73.
23. Liau K H, Ruo L, Shia J, et al. Outcome of partial hepatectomy for large (>10 cm) hepatocellular carcinoma. Cancer 2005; 104: 1948-55.
24. Yang H I, Lu S N, Liaw Y F, et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002; 347: 168-74.
25. Chen C H, Huang G T, Lee H S, Yang P M, Chen D S, Sheu J C. Clinical impact of screening first-degree relatives of patients with hepatocellular carcinoma. J Clin Gastroenterol 1998; 27: 236-9.
26. Yu M W, Chang H C, Liaw Y F, et al. Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives. J Natl Cancer Inst 2000; 92: 1159-64.
27. Yu M W, Yeh S H, Chen P J, et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: A prospective study in men. J Natl Cancer Inst 2005; 97: 265-72.
28. Chen C J, Yang H I, Su J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295: 65-73.
29. Chen D S, Hsu N H, Sung J L, et al. A mass vaccination program in Taiwan against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers. JAMA 1987; 257: 2597-603.
30. Ni Y H, Chang M H, Huang L M, et al. Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after mass hepatitis B vaccination. Ann Intern Med 2001; 135: 796-800.
31. Chang M H, Chen C J, Lai M S, et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med 1997; 336: 1855-9.
32. Kao J H, Chen D S. Global control of hepatitis B virus infection. Lancet Infect Dis 2002; 2: 395-403.