The influence of N- and O-glycosylation inhibitors on the glycosylation profile of cellular membrane proteins and adhesive properties of carcinoma cell lines

International Journal of Molecular Medicine

Volumn 17, Issue 4, 2006, Pages 669-674

  Paszkiewicz Gadek, Anna ^a   Porowska, Halina ^a   Lemancewicz, Dorota ^a   Wolczynski, Slawomir ^a   Gindzienski, Andrzej ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Adhesion; Benzyl N acetyl galactosaminide; Cancer cell lines; MUC1; Tunicamycin

Indexed keywords

1 BENZYL 2 ACETAMIDO 2 GALACTOPYRANOSIDE; 1-BENZYL-2-ACETAMIDO-2-GALACTOPYRANOSIDE; COLLAGEN TYPE 1; DRUG DERIVATIVE; GALACTOSE; MEMBRANE PROTEIN; MUC1 PROTEIN, HUMAN; MUCIN; T ANTIGEN, MUCIN TYPE CARBOHYDRATE; T ANTIGEN, MUCIN-TYPE CARBOHYDRATE; TN ANTIGEN; TUMOR ANTIGEN; TUNICAMYCIN; VERY LATE ACTIVATION ANTIGEN 2;

ARTICLE; BREAST TUMOR; CELL ADHESION; DRUG EFFECT; ENDOMETRIUM TUMOR; FEMALE; FLOW CYTOMETRY; GLYCOSYLATION; HUMAN; METABOLISM; PATHOLOGY; PROTEIN BINDING; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIGENS, NEOPLASM; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; COLLAGEN TYPE I; ENDOMETRIAL NEOPLASMS; FEMALE; FLOW CYTOMETRY; GALACTOSE; GLYCOSYLATION; HUMANS; INTEGRIN ALPHA2BETA1; MEMBRANE PROTEINS; MUCINS; PROTEIN BINDING; TUNICAMYCIN;

EID: 33746731794     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.4.669     Document Type: Article

References (24)

1. Brockhausen I: Pathways of O-glycan biosynthesis in cancer cells. Biochim Biophys Acta 1473: 67-95, 1999.
2. Green RF, Meiss HK and Rodriguez-Boulan E: Glycosylation does not determine segregation of viral envelope proteins in the plasma membrane of epithelial cells. J Cell Biol 89: 230-239, 1981.
3. Ho JJL, Jaituni RS, Crawley SC, Yano SC, Gum JR and Kim YS: N-glycosylation is required for the surface localization of MUC17 mucin. Int J Oncol 23: 585-592, 2003.
4. Huet G, Kim I, De Bolos C, Lo-Guidice JM, Moreau O, Hemon B, Richet C, Delannoy P, Real FX and Degand P: Characterization of mucins and proteoglycans synthesized by a mucin-secreting HT-29 cell population. J Cell Sci 108: 1275-1285, 1995.
5. Hennebicq-Reig S, Lesuffluer T, Capon C, De Bolos C, Kim I, Moreau O, Richet C, Hemon B, Recchi MA, Maes E, Aubert JP, Real FX, Zweibaum A, Delannoy P, Degand P and Huet G: Permanent exposure of mucin-secreting HT-29 cells to benzyl-N-acetyl-alpha-D-galactosaminide induces abnormal Oglycosylation of mucins and inhibits constitutive and stimulated MUC5AC secretion. Biochem J 334: 283-295, 1998.
6. Huet G, Hennebicq-Reig S, De Bolos C, Ulloa F, Lesuffleur T, Barbat A, Carriere V, Kim I, Real FX, Delannoy P and Zweibaum A: GalNAc-α-O-benzyl inhibits NeuAcα2-3 glycosylation and blocks the intracellular transport of apical glycoproteins and mucus in differentiated HT-29 cells. J Cell Biol 15: 1311-1322, 1998.
7. Gouyer V, Leteurtre E, Delmotte P, Steelant WFA, Krzewinski-Recchi MA, Zanette JP, Lesuffleur T, Trugnan G, Delannoy P and Huet G: Differential effect of GalNAc-alpha-O-bn on intracellular trafficking in enterocytic HT-29 and Caco-2 cells: relation with the glycosylatransferase expression pattern. J Cell Sci 114: 1455-1471, 2001.
8. Kim YS, Gum JR and Brockhausen I: Mucin glycoproteins in neoplasia. Glycoconj J 13: 693-707, 1996.
9. Lesuffleur T, Zweibaum A. and Real FX: Mucins in normal and neoplastic human gastrointestinal tissues. Crit Rev Oncol Hematol 17: 153-180, 1994.
10. Ligtenberg MJL, Buijs F, Vos HL and Hilkens J: Suppression of cellular aggregation by high level of episialin. Cancer Res 52: 2318-2324, 1992.
11. Wesseling J, van der Valk SW, Vos HL, Sonnenberg A and Hilkens J: Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol 129: 255-265, 1995.
12. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
13. Porowska H, Paszkiewicz-Gadek A, Anchim T, Wolczynski S and Gindzienski A: Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells. Int J Mol Med 13: 459-464, 2004.
14. Paszkiewicz-Gadek A, Porowska H, Pietruczuk M, Haczynski J, Kisiel D and Wolczynski S: Effect of estradiol and raloxifene on MUC1 expression and adhesive properties of Ishikawa cells. Oncol Rep 14: 583-589, 2005.
15. Dall'Olio F: Proteins glycosylation in cancer biology: an overview. Clin Mol Pathol 49: M126-M135, 1996.
16. Kim YJ and Varki A: Perspectives on the significance of altered glycosylation of glycoproteins in cancer. Glycoconj J 14: 569-576, 1997.
17. Kim YS: Altered glycosylation of mucin glycoproteins in colonic neoplasia. J Cell Biochem 9 (Suppl): 1-6, 1992.
18. Hanisch FG, Stadie TR, Deutzmann F and Peter-Katalinic J: MUC1 glycoforms in breast cancer-cell line T47D as a model for carcinoma-associated alterations of O-glycosylation. Eur J Biochem 236: 318-327, 1996.
19. Berry N, Jones DB, Smallwood J, Taylor I, Kirkham N and Taylor-Papadimitriou J: The prognostic value of the monoclonal antibodies HMFG1 and HMFG2 in breast cancer. Br J Cancer 51: 179-186, 1985.
20. Chu J-S and Chang K-J: Mucin expression in mucinous carcinoma and other invasive carcinomas of the breast. Cancer Lett 142: 121-127, 1999.
21. Fukuda M: Roles of mucin-type O-glycans in cell adhesion. Biochim Biophys Acta 1573: 394-405, 2002.
22. Shimizu H, Koyama N, Asada M and Yoshimatsu K: Aberrant expression of integrin and erbB subunits in breast cancer cell lines. Int J Oncol 21: 1073-1079, 2002.
23. Gristead JS, Koganty RR, Krantz MJ, Longenecker BM and Campbell AP: Effect of glycosylation on MUC1 humoral immune recognition: NMR studies of MUC1 glycopeptide-antibody interactions. Biochemistry 41: 9946-9961, 2002.
24. Julien S, Lagadec C, Krzewinski-Recchi MA, Courtand G, Bourhis XL and Delannoy P: Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration. Breast Cancer Res Treat 90: 77-84, 2005.