First look at the effect of overexpression of TIGR/MYOC on the transcriptome of the human trabecular meshwork

Experimental Eye Research

Volumn 82, Issue 6 SPEC. ISS., 2006, Pages 1002-1010

  Borrás, Teresa ^a   Bryant, Paul A ^a   Chisolm, Sarah S ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

differential gene expression; human trabecular meshwork; microarrays; myocilin; TaqMan PCR

Indexed keywords

ADENOVIRUS VECTOR; ANGIOPOIETIN 2; COLLAGEN TYPE 1; COMPLEMENTARY DNA; INTERSTITIAL COLLAGENASE; MYOCILIN; THROMBOMODULIN; TRANSCRIPTOME; VASCULAR CELL ADHESION MOLECULE 1; CELL CYCLE PROTEIN; CYTOSKELETON PROTEIN; EYE PROTEIN; GAS1 PROTEIN, HUMAN; GLYCOPROTEIN; MEMBRANE PROTEIN; TRABECULAR MESHWORK-INDUCED GLUCOCORTICOID RESPONSE PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GLAUCOMA; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; TRABECULAR MESHWORK; UBIQUITINATION; UPREGULATION; VIRUS PARTICLE; WILD TYPE; CELL CULTURE; CHEMISTRY; GENETIC TRANSDUCTION; GENETICS; METHODOLOGY; MUTATION; POLYMERASE CHAIN REACTION;

ANGIOPOIETIN-2; CELL CYCLE PROTEINS; CELLS, CULTURED; COLLAGEN TYPE I; CYTOSKELETAL PROTEINS; DOWN-REGULATION; EYE PROTEINS; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; MATRIX METALLOPROTEINASE 1; MEMBRANE PROTEINS; MUTATION; POLYMERASE CHAIN REACTION; THROMBOMODULIN; TRABECULAR MESHWORK; TRANSDUCTION, GENETIC; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33746709470     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2005.11.005     Document Type: Article

References (43)

1. Alexander J.P., Samples J.R., Van Buskirk E.M., and Acott T.S. Expression of matrix metalloproteinases and inhibitor by human trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 32 (1991) 172-180
2. Alexander J.P., Samples J.R., and Acott T.S. Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression. Curr. Eye Res. 17 (1998) 276-285
3. Aroca-Aguilar J.D., Sanchez-Sanchez F., Ghosh S., Coca-Prados M., and Escribano J. Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227. J. Biol. Chem. 280 (2005) 21043-21051
4. Boffa M.C., Burke B., and Haudenschild C.C. Preservation of thrombomodulin antigen on vascular and extravascular surfaces. J. Histochem. Cytochem. 35 (1987) 1267-1276
5. Borrás T., Morozova T.V., Heinsohn S.L., Lyman R.F., Mackay T.F., and Anholt R.R. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Genetics 163 (2003) 637-645
6. Bradley J.M., Vranka J., Colvis C.M., Conger D.M., Alexander J.P., Fisk A.S., et al. Effect of matrix metalloproteinases activity on outflow in perfused human organ culture. Invest. Ophthalmol. Vis. Sci. 39 (1998) 2649-2658
7. Caballero M., and Borrás T. Inefficient processing of an olfactomedin-deficient myocilin mutant: potential physiological relevance to glaucoma. Biochem. Biophys. Res. Commun. 282 (2001) 662-670
8. Caballero M., Rowlette L.L., and Borras T. Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain. Biochim. Biophys. Acta 1502 (2000) 447-460
9. Cheng L.E., Ueda J., Wentz-Hunter K., and Yue B.Y. Age independent expression of myocilin in the human trabecular meshwork. Int. J. Mol. Med. 10 (2002) 33-40
10. Fautsch M.P., Bahler C.K., Jewison D.J., and Johnson D.H. Recombinant TIGR/MYOC increases outflow resistance in the human anterior segment. Invest. Ophthalmol. Vis. Sci. 41 (2000) 4163-4168
11. Fingert J.H., Stone E.M., Sheffield V.C., and Alward W.L. Myocilin glaucoma. Surv. Ophthalmol. 47 (2002) 547-561
12. Gobeil S., Rodrigue M.A., Moisan S., Nguyen T.D., Polansky J.R., Morissette J., et al. Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants. Invest. Ophthalmol. Vis. Sci. 45 (2004) 3560-3567
13. Goldwich A., Ethier C.R., Chan D.W., and Tamm E.R. Perfusion with the olfactomedin domain of myocilin does not affect outflow facility. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1953-1961
14. Gonzalez P., Epstein D.L., and Borrás T. Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. Invest. Ophthalmol. Vis. Sci. 41 (2000) 352-361
15. Gottanka J., Chan D., Eichhorn M., Lütjen-Drecoll E., and Ethier C.R. Effects of TGF-beta2 in perfused human eyes. Invest. Ophthalmol. Vis. Sci. 45 (2004) 153-158
16. Gould D.B., Miceli-Libby L., Savinova O.V., Torrado M., Tomarev S.I., Smith R.S., et al. Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma. Mol. Cell Biol. 24 (2004) 9019-9025
17. Ikeda T., Ishii H., Higuchi T., Sato K., Hayashi Y., Ikeda K., et al. Localization of thrombomodulin in the anterior segment of the human eye. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3383-3390
18. Jacobson N., Andrews M., Shepard A.R., Nishimura D., Searby C., Fingert J.H., et al. Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor. Hum. Mol. Genet. 10 (2001) 117-125
19. Kaur K., Reddy A.B., Mukhopadhyay A., Mandal A.K., Hasnain S.E., Ray K., et al. Myocilin gene implicated in primary congenital glaucoma. Clin. Genet. 67 (2005) 335-340
20. Kim B.S., Savinova O.V., Reedy M.V., Martin J., Lun Y., Gan L., et al. Targeted disruption of the myocilin gene (Myoc) suggests that human glaucoma-causing mutations are gain of function. Mol. Cell Biol. 21 (2001) 7707-7713
21. Kubota R., Noda S., Wang Y., Minoshima S., Asakawa S., Kudoh J., et al. A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping. Genomics 41 (1997) 360-369
22. Lo W.R., Rowlette L.L., Caballero M., Yang P., Hernandez M.R., and Borrás T. Tissue differential microarray analysis of dexamethasone induction reveals potential mechanisms of steroid glaucoma. Invest. Ophthalmol. Vis. Sci. 44 (2003) 473-485
23. Lütjen-Drecoll E., May C.A., Polansky J.R., Johnson D.H., Bloemendal H., and Nguyen T.D. Localization of the stress proteins alpha B-crystallin and trabecular meshwork inducible glucocorticoid response protein in normal and glaucomatous trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 39 (1998) 517-525
24. McCachren S.S., Diggs J., Weinberg J.B., and Dittman W.A. Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. Blood 78 (1991) 3128-3132
25. O'Brien T.E., Metheney C.D., and Polansky J.R. Immunofluorescence method for quantifying the trabecular meshwork glucocorticoid response (TIGR) protein in trabecular meshwork and Schlemm's canal cells. Curr. Eye Res. 19 (1999) 517-524
26. Oliner J., Min H., Leal J., Yu D., Rao S., You E., et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 6 (2004) 507-516
27. Ortego J., Escribano J., and Coca-Prados M. Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Lett. 413 (1997) 349-353
28. Polansky J.R., Kurtz R.M., Fauss D.J., Kim R.Y., and Bloom E. In vitro correlates of glucocorticoid effects on intraocular pressure. In: Krieglstein G.K. (Ed). Glaucoma Update IV (1991), Springer, Berlin, Heilderberg 20-29
29. Poola I., DeWitty R.L., Marshalleck J.J., Bhatnagar R., Abraham J., and Leffall L.D. Identification of MMP-1 as a putative breast cancer predictive marker by global gene expression analysis. Nat. Med. 11 (2005) 481-483
30. Rozsa F.W., Shimizu S., Lichter P.R., Johnson A.T., Othman M.I., Scott K., et al. GLC1A mutations point to regions of potential functional importance on the TIGR/MYOC protein. Mol. Vis. 4 (1998) 20
31. Sarfarazi M. Recent advances in molecular genetics of glaucomas. [Review] [91 refs]. Hum. Mol. Genet. 6 (1997) 1667-1677
32. Shepard A.R., Jacobson N., Fingert J.H., Stone E.M., Sheffield V.C., and Clark A.F. Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 42 (2001) 3173-3181
33. Stilwell J.L., and Samulski R.J. Role of viral vectors and virion shells in cellular gene expression. Mol. Ther. 9 (2004) 337-346
34. Stone E.M., Fingert J.H., Alward W.L.M., Nguyen T.D., Polansky J.R., Sunden S.L.F., et al. Identification of a gene that causes primary open angle glaucoma. Science 275 (1997) 668-670
35. Vincent A.L., Billingsley G., Buys Y., Levin A.V., Priston M., Trope G., et al. Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene. Am. J. Hum. Genet. 70 (2002) 448-460
36. Vittitow J., and Borrás T. Genes expressed in the human trabecular meshwork during pressure induced homeostatic response. J. Cell. Physiol. 201 (2004) 126-137
37. Wentz-Hunter K., Shen X., and Yue B.Y. Distribution of myocilin, a glaucoma gene product, in human corneal fibroblasts. Mol. Vis. 9 (2003) 308-314
38. Wentz-Hunter K., Kubota R., Shen X., and Yue B.Y. Extracellular myocilin affects activity of human trabecular meshwork cells. J. Cell Physiol. 200 (2004) 45-52
39. Wentz-Hunter K., Shen X., Okazaki K., Tanihara H., and Yue B.Y. Overexpression of myocilin in cultured human trabecular meshwork cells. Exp. Cell Res. 297 (2004) 39-48
40. Wiggs J.L., and Vollrath D. Molecular and clinical evaluation of a patient hemizygous for TIGR/MYOC. Arch. Ophthalmol. 119 (2001) 1674-1678
41. Zhao X., Ramsey K.E., Stephan D.A., and Russell P. Gene and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta. Invest. Ophthalmol. Vis. Sci. 45 (2004) 4023-4034
42. Zhou Z., and Vollrath D. A cellular assay distinguishes normal and mutant TIGR/myocilin protein. Hum. Mol. Genet. 8 (1999) 2221-2228
43. Zillig M., Wurm A., Grehn F.J., Russell P., and Tamm E.R. Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice. Invest. Ophthalmol. Vis. Sci. 46 (2005) 223-234