Nonsecretory plasma cell myeloma - Becoming even more rare with serum free light-chain assay: A brief review

Archives of Pathology and Laboratory Medicine

Volumn 130, Issue 8, 2006, Pages 1212-1215

  Shaw, Gene R ^a  

^a MARSHFIELD CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD56 ANTIGEN; CD79A ANTIGEN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; SYNDECAN 1;

BONE MARROW BIOPSY; CHROMOSOME ANALYSIS; CLONAL VARIATION; DIAGNOSTIC VALUE; FREE LIGHT CHAIN ASSAY; HUMAN; HYPOGAMMAGLOBULINEMIA; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; MULTIPLE MYELOMA; NEPHELOMETRY; NONSECRETORY PLASMA CELL MYELOMA; PLASMA CELL DYSCRASIA; RARE DISEASE; REVIEW; SERUM; SYSTEMATIC REVIEW;

AGAMMAGLOBULINEMIA; BONE MARROW CELLS; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN LIGHT CHAINS; MYELOMA PROTEINS; OSTEOLYSIS; PLASMA CELLS; PLASMACYTOMA; REAGENT KITS, DIAGNOSTIC;

EID: 33746704381     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (21)

1. Blade J, Kyle RA. Nonsecretory myeloma, immunoglobulin D myeloma, and plasma cell leukemia. Hematol Oncol Clin North Am. 1999;13:1259-1272.
2. Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78:21-33.
3. Drayson M, Tang LX, Drew R, Mead GP, Carr-Smith H, Bradwell AR. Serum free light-chain measurements for identifying and monitoring patients with non-secretory multiple myeloma. Blood. 2001;97:2900-2902.
4. Katzmann JA, Abraham RS, Dispenzieri A, Lust JA, Kyle RA. Diagnostic performance of quantitative kappa and lambda free light chain assays in clinical practice. Clin Chem. 2005;51:878-881.
5. Bradwell AR, Mead GP, Carr-Smith HD. Methods for free light chain mea-surement. In: Serum Free Light Analysis. 3rd ed. Birmingham, UK: The Binding Site Ltd; 2005:23-41.
6. Bradwell AR. Serum free light chain measurements move to center stage. Clin Chem. 2005;51:805-807.
7. Reid SD, Augustson BM, Katsavara H, et al. Screening for monoclonal gammopathy: improved sensitivity using serum free light chain assays [abstract 81]. Br J Haematol. 2005;129:26.
8. Bakshi NA, Gulbranson R, Garstka D, Bradwell AR, Keren DF. Serum free light chain (FLC) measurement can aid capillary zone electrophoresis in detecting subtle FLC-producing M proteins. Am J Clin Pathol. 2005;124:214-218.
9. Lachmann HJ, Gallimore R, Gillmore JD, et al. Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy. Br J Haematol. 2003;122:78-84.
10. Abraham RS, Katzmann JA, Clark RJ, Bradwell AR, Kyle RA, Gertz MA. Quantitative analysis of serum free light chains: a new marker for the diagnostic evaluation of primary systemic amyloidosis. Am J Clin Pathol. 2003;119:274-278.
11. Leleu X, Moreau AS, Coiteux V, et al. Serum free light chain assays in solitary bone plasmacytoma [abstract 186]. Br J Haematol. 2005;129:59.
12. Greipp PR, Raymond NM, Kyle RA, O'Fallon WM. Multiple myeloma: significance of plasmablastic subtype in morphological classification. Blood. 1985;65:305-310.
13. Magro C, Crowson AN, Porcu P, Nuovo GJ. Automated kappa and lambda light chain mRNA expression for the assessment of B-cell clonality in cutaneous B-cell infiltrates: its utility and diagnostic application. J Cutan Pathol. 2003;30:504-511.
14. Gafumbegete E, Richter S, Jonas L, Nizze H, Makovitzky J. Nonsecretory multiple myeloma with amyloidosis: a case report and review of the literature. Virchows Arch. 2004;445:531-536.
15. Mathew P, Ahmann GJ, Witzig TE, Roche PC, Kyle RA, Greipp PR. Clinicopathological correlates of CD56 expression in multiple myeloma: a unique entity? Br J Haematol. 1995;90:459-461.
16. Martin P, Santon A, Bellas C. Neural cell adhesion molecule expression in plasma cells in bone marrow biopsies and aspirates allows discrimination between multiple myeloma, monoclonal gammopathy of uncertain significance and polyclonal plasmacytosis. Histopathology. 2004;44:375-380.
17. Terpos E, Apperley JF, Samson D, et al. Autologous stem cell transplantation in multiple myeloma: improved survival in nonsecretory multiple myeloma but lack of influence of age, status at transplant, previous treatment and conditioning regimen: a single-centre experience in 127 patients. Bone Marrow Transplant. 2003;31:163-170.
18. Fukushima Y, Miura I, Niitsu H, et al. A 14q+ marker chromosome due to t(11;14) in a case of nonsecretory plasma cell leukemia. Rinsho Ketsueki. 1986;27:2124-2130.
19. Fujii H, Maekawa T, Kanoh T, et al. Nonsecretory myeloma with t(14; 18)(q32;21) chromosome abnormality. Rinsho Ketsueki. 1987;28:601-607.
20. Bosman C, Fusilli S, Bisceglia M, Musto P, Corsi A. Oncocytic nonsecretory multiple myeloma: a clinicopathologic study of a case and review of the literature. Acta Haematol. 1996;96:50-56.
21. Coriu D, Weaver K, Schell M, et al. A molecular basis for nonsecretory myeloma. Blood. 2004;104:829-831.