Evaluation of the pathogenicity of the Bacteroides fragilis toxin gene subtypes in gnotobiotic mice

Current Microbiology

Volumn 53, Issue 2, 2006, Pages 113-117

  Nakano, Viviane ^a   Gomes, Danielle A ^b   Arantes, Rosa M E ^b   Nicoli, Jacques R ^b   Avila Campos, Mario J ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; BACTEROIDES FRAGILIS TOXIN 1; BACTEROIDES FRAGILIS TOXIN 2; BACTEROIDES FRAGILIS TOXIN 3; ENTEROTOXIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL STRAIN; BACTEROIDES FRAGILIS; CONTROLLED STUDY; EDEMA; FECES ANALYSIS; GENE FUNCTION; GERMFREE ANIMAL; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; INTESTINE ULCER; MOUSE; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL;

ANIMALS; BACTERIAL TOXINS; BACTEROIDES FRAGILIS; BACTEROIDES INFECTIONS; CHILD; CHILD, PRESCHOOL; DIARRHEA; EDEMA; ENTEROTOXINS; GERM-FREE LIFE; HUMANS; METALLOENDOPEPTIDASES; MICE;

ANIMALIA; BACTEROIDES FRAGILIS;

EID: 33746701349     PISSN: 03438651     EISSN: 14320991     Source Type: Journal    
DOI: 10.1007/s00284-005-0321-6     Document Type: Article

References (24)

1. Arantes RME, Nogueira AMMF (1997) Distribution of enteroglucagon- and peptide YY- immunoreactive cells in the intestinal mucosa of germ-free and conventional mice. Cell Tissue Res 290:61-69
2. Bouquet P, Munro P, Fiorentini C, Just I (1998) Toxins from anaerobic bacteria: specificity and molecular mechanisms of action. Curr Opin Microbiol 1:66-74
3. Chambers FG, Koshy SS, Saidi RF, Clark DP, Moore RD, Sears CL (1997) Bacteroides fragilis toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro. Infect Immun 67:3561-3570
4. Chung GT, Franco AA, Wu S, Rhie GE, Cheng R, Oh HB, Sears CL (1997) Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis. Infect Immun 67:4945-4949
5. Collins JE, Bergland ME, Myers LL, Shoop DS (1989) Exfoliating colitis associated with enterotoxigenic Bacteroides fragilis in a piglet. J Vet Diagn 1:349-351
6. D'Abusco AS, Del Grosso M, Censini S, Covacci A, Pantosti A (2000) The alleles of the bft gene are distributed differently among enterotoxigenic Bacteroides fragilis strains from human sources and can be present in double copies. J Clin Microbiol 38:607-612
7. Donelli G, Fabbri A, Fiorentini C (1996) Bacteroides fragilis enterotoxin induces cytoskeletal changes and surfaces blebbling in HT-29 cells. Infect Immun 64:113-119
8. Duimstra JR, Myers LL, Collins JE, Benfield DA, Shoop DS, Bradbury WC (1991) Enterovirulence of enterotoxigenic Bacteroides fragilis in gnotobiotic pigs. Vet Pathol 28:514-518
9. Franco AA, Mundy LM, Trucksis M, Wu S, Kasper JB, Sears CL (1997) Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene. Infect Immun 65:1007-1013
10. Franco AA, Cheng RK, Chung GT, Wu S, Oh HB, Sears CL (1999) Molecular evolution of the pathogenicity island of enterotoxigenic Bacteroides fragilis. J Bacteriol 181:6623-6633
11. Kato N, Liu C, Kato H, Watanabe K, Nakamura H, Iwai N, Ueno K (2000) A new subtype of the metalloprotease toxin gene and the incidence of the three bft subtypes among Bacteroides fragilis isolates in Japan. FEMS Microbiol Lett 182:171-176
12. Koshy SS, Montrose MH, Sears CL (1996) Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis. Infect Immun 64:5022-5028
13. Miysohi S, Shinoda S (2000) Microbial metalloproteases and pathogenesis. Microbes Infect 2:91-98
14. Moncrief JS, Obiso R Jr, Barroso LA, Kling JJ, Wright RL, Van Tassell RL, Lyerly DM, Wilkins TD (1995) The enterotoxin of Bacteroides fragilis is a metalloprotease. Infect Immun 63:175-181
15. Moncrief J, Duncan A, Wright R, Barroso L, Wilkins TD (1998) Molecular characterization of the fragilysin pathogenicity islet of enterotoxigenic Bacteroides fragilis. Infect Immun 66:1735-1739
16. Myers LL, Firehammer BD, Shoop DS, Border MM (1984) Bacteroides fragilis: a possible cause of acute diarrhea disease in newborn lambs. Infect Immun 44:241-244
17. National Research Council, Guide for the Care and Use of Laboratory Animals (1996) Washington, DC: National Academy Press
18. Obiso RJ, Lyerly DM, Van Tassell RL, Wilkins TD (1995) Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo. Infect Immun 63:3820-3826
19. Pantosti A, Cerquetti M, Collangeli R, D'Ambrosio F (1994) Detection of intestinal and extra-intestinal Bacteroides fragilis by the HT-29 cytotoxicity assay. J Med Microbiol 41:191-196
20. Pantosti A, Menozzi MG, Frate A, Sanfilippo L, D'Ambrosio F, Malpeli M (1997) Detection of enterotoxigenic Bacteroides fragilis and its toxin in stool samples from adults and children in Italy. Clin Infect Dis 24:12-16
21. Pleasants JR (1974) In: Melby EC Jr, Altmann NH (eds) Handbook of Laboratory Animal Science. Cleveland, OH: CRC Press. pp 119-174
22. Riegler M, Lotz M, Sears CL, Pothoulakis C, Castaglioulo I, Wang CC, Sedivy R, Sogukoglu T, Cosentini E, Bischof G, Feil W, Teleky B, Hamilton G, LaMont JT, Wenzl E (1999) Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro. Gut 44:504-510
23. Sears CL (2001) The toxins of Bacteroides fragilis. Anaerobe 39:1737-1746
24. Wu S, Klim KC, Huang J, Saidi RF, Sears C (1998) Bacteroides fragilis enterotoxin cleaves the zonula adherents protein E-cadherin. Proc Natl Acad Sci USA 95:14979-14984