Synthesis of new 2-(5-aryl-3-styryl-4,5-dihydro-1H-pyrazol-1-yl)-4- (trifluoromethyl)pyrimidines

Synthesis

Volumn , Issue 14, 2006, Pages 2349-2356

  Flores, Darlene C ^a   Fiss, Gabriela F ^a   Wbatuba, Leticia S ^b   Martins, Marcos A P ^a   Burrow, Robert A ^a   Flores, Alex F C ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b CENTRO UNIVERSITÁRIO FRANCISCANO   (Brazil)

Author keywords

1H pyrazoles; Homogeneous catalysis; Pyrimidines

Indexed keywords

CATALYSIS; CONDENSATION; CRYSTAL STRUCTURE; SYNTHESIS (CHEMICAL);

1H-PYRAZOLES; CYCLIZATIONS; HOMOGENEOUS CATALYSIS; PYRIMIDINES;

NUCLEIC ACIDS;

2 (5 ARYL 3 STYRYL 4,5 DIHYDRO 1H PYRAZOL 1 YL) 4 TRIFLUOROMETHYL)PYRIMIDINE; 5 ARYL 1 CARBOXAMINO 3 STYRYL 4,5 DIHYDRO 1H PYRAZOLE; ETHYL 3 [2 (5 PHENYL 3 STYRYL 4,5 DIHYDRO 1H PYRAZOL 1 YL) 4 (TRIFLUOROMETHYL)PYRIMIDIN 6 YL]PROPANOIC ACID; PROPIONIC ACID DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CYCLIZATION; SYNTHESIS;

EID: 33746623333     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-942431     Document Type: Article

References (22)

1. Chimenti, F.; Bolasco, A.; Manna, F.; Secci, D.; Chimenti, P.; Befani, O.; Turini, P.; Giovannini, V.; Mondovi, B.; Cirilli, R.; La Torre, F. J. Med. Chem. 2004, 47, 2071.
2. Meier, H.; Hormaza, A. Eur. J. Org. Chem. 2003, 3372.
3. Lévai, A. J. Heterocycl. Chem. 2002, 39, 1.
4. Palaska, E.; Aytemir, M.; Uzbay, I. T.; Erol, D. Eur. J. Med. Chem. 2001, 36, 539.
5. Zanatta, N.; Flores, D. C.; Madruga, C. C.; Faoro, D.; Flores, A. F. C.; Bonacorso, H. G.; Martins, M. A. P. Synthesis 2003, 894.
6. (a) Bonacorso, H. G.; Wentz, A. P.; Zanatta, N.; Martins, M. A. P. Synthesis 2001, 1505.
7. (b) Bonacorso, H. G.; Martins, D. B.; Martins, M. A. P.; Zanatta, N.; Flores, A. F. C. Synthesis 2005, 809.
8. Huang, Y. R.; Katzenellenbogen, J. A. Org. Lett. 2000, 2, 2833.
9. Fu, H.; Xiao, D.; Xie, R.; Ji, X.; Yao, J.-N. Can. J. Chem. 2003, 81, 7.
10. Fahrni, C. J.; Yang, L.; VanDerveer, D. G. J. Am. Chem. Soc. 2003, 125, 3799.
11. Xiao, D.; Xi, L.; Yang, W.; Fu, H.; Shuai, Z.; Fang, Y.; Yao, J. J. Am. Chem. Soc. 2003, 125, 6740.
12. Wha, O. h. S.; Ri Zhang, D.; Soo Kang, Y. Mater. Sci. Eng., C 2004, 24, 131.
13. Zhang, X. H.; Lai, W. Y.; Gao, Z. Q.; Wong, T. C.; Lee, C. S.; Kwong, H. L.; Lee, S. T.; Wu, S. K. Chem. Phys. Lett. 2000, 320, 77.
14. Lévai, A.; Patonay, T.; Silva, A. M. S.; Pinto, D. C. G. A.; Cavaleiro, J. A. S. J. Heterocycl. Chem. 2002, 39, 751.
15. (a) Azarifar, D.; Shaebanzadeh, M. Molecules 2002, 7, 885.
16. (b) Vijayabaskar, V.; Perumal, S.; Selvaraj, S.; Lycka, A.; Murugan, R.; Balasubramanian, M. Magn. Reson. Chem. 1999, 37, 133.
17. Nauduri, D.; Reddy, G. B. S. Chem. Pharm. Bull. 1998, 46, 1254.
18. Dove, M. F. A.; Sanders, J. C. P.; Appelman, E. H. Magn. Reson. Chem. 1995, 33, 44.
19. Sevenard, D. V.; Khomutov, O. G.; Koryakova, O. V.; Sattarova, V. V.; Kodess, M. I.; Stellen, J.; Loop, I.; Lork, E.; Pashkevich, K. I.; Röschenthaler, G.-V. Synthesis 2000, 1738.
20. Berger, S.; Braun, S.; Kalinowski, H.-O. NMR Spectroscopy of the Non-metallic Elements; Wiley: Chichester, 1997, 398-400.
21. SHELXTL 6.14; Broker AXS Inc.: Madison WI, 2003.
22. Farrugia, L. J. J. Appl. Crystallogr. 1999, 32, 837.