Evidence of choline depletion and reduced betaine and dimethylglycine with increased homocysteine in plasma of children with cystic fibrosis

Journal of Nutrition

Volumn 136, Issue 8, 2006, Pages 2226-2231

  Innis, Sheila M ^a   Hasman, David ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CHOLINE; DIMETHYLGLYCINE; HOMOCYSTEINE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ADOLESCENT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; SCHOOL CHILD; TANDEM MASS SPECTROMETRY;

EID: 33746620057     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.8.2226     Document Type: Article

References (48)

1. Nasr SZ. Cystic fibrosis in adolescents and young adults. Adolesc Med. 2000;11:589-603.
2. Rommens JM, Iannuzzi MC, Kerem B, Drumm ML, Melmer G, Dean M, Rozmahel R, Cole JL, Kennedy D, Hidaka N. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science. 1989;245:1059-65.
3. Reisin IL, Prat AG, Abraham EH, Amara JF, Gregory RJ, Ausiello DA, Cantiello HF. The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. J Biol Chem. 1994;269:20584-91.
4. Schwiebert EM, Egan ME, Hwang TH, Fulmer SB, Allen SS, Cutting GR, Guggino WB. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell. 1995;81:1063-73.
5. Davidson AGF. Gastrointestinal and pancreatic disease in cystic fibrosis. In Hodson ME, Geddes DM, editors. Cystic fibrosis, 2nd edition. Oxford: Oxford University Press; 2000. pp. 384-95.
6. Chen AH, Innis SM, Davidson AGF, James SJ. Phosphatidylcholine and lysophosphatidylcholine excretion is increased in children with cystic fibrosis and is associated with plasma homocysteine S-adenosylhomocysteine and S-adenosylmethionine. Am J Clin Nutr. 2005;81:686-91.
7. Barraclough M, Taylor CJ. Twenty-four hour ambulatory gastric and duodenal pH profiles in cystic fibrosis: effect of duodenal hyperacidity on pancreatic enzyme function and fat absorption. J Pediatr Gastroenterol Nutr. 1996;23:45-50.
8. Francisco MP, Wagner MH, Sherman JM, Theriaque D, Bowser E, Novak DA. Ranitidine and omeprazole as adjuvant therapty to pancrelipase to improve fat absorption in patients with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2002;35:79-83.
9. Proesmans M, De Boeck K. Omeprazole, a proton pump inhibitor, improves residual steatorrhea in cystic fibrosis patients treated with high dose pancreatic enzymes. Eur J Pediatr. 2003;162:760-3.
10. Colombo C, Battezzati PM, Strazzabosco M, Podda M. Liver and biliary problems in cystic fibrosis. Semin Liver Dis. 1998;18:227-35.
11. Westaby D. Liver and biliary disease in cystic fibrosis. In Hodson ME, Geddes DM, editors. Cystic fibrosis, 2nd edition. Oxford: Oxford University Press; 2000. pp. 289-300.
12. Zeisel SH, Blusztajn JK. Choline and human nutrition. Annu Rev Nutr. 1994;14:269-96.
13. Vance DE, Walkey CJ, Cui Z. Phosphatidylethanolamine N-methyltransferase from liver. Biochim Biophys Acta. 1997;1348:142-50.
14. Fowler B. Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. Semin Vasc Med. 2005;5:77-86.
15. Ueland PM, Holm PI, Hustad S. Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin Chem Lab Med. 2005;43:1069-75.
16. Gregory, 3rd JF, Quinlivan EP. In vivo kinetics of folate metabolism. Annu Rev Nutr. 2002;22:199-220.
17. Porter DH, Cook RM, Wagner C. Enzymatic properties of dimethylglycine, dehydrogenase and sarcosine dehydrogerase from rat liver. Arch Biochem Biophys. 1985;243:396-407.
18. Kohlmeier M, da Costa KA, Fisher LM, Zeisel SH. Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci USA. 2005;102:16025-30.
19. Holm PI, Ueland PM, Vollset SE, Midttum O, Blom HJ, Keijzer MB, den Heijer M. Betaine and folate status as cooperative determinants of plasma homocysteine in humans. Arterioscler Thromb Vasc Biol. 2005;25:379-85.
20. Schwahn BC, Chen Z, Laryea MD, Wendel U, Lussier-Cacan S, Genest J, Jr., Mar MH, Zeisel SH, Castro C, et al. Homocysteine-betaine interactions in a murine model of S, 10-methylene tetrahydrofolate reductase deficiency. FASEB J. 2003;17:512-4.
21. Kim YI, Miller JW, da Costa KA, Nadeau M, Smith D, Selhub J, Zeisel SH, Mason JB. Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver. J Nutr. 1994;124:2197-203.
22. Zeisel SH, Zola T, daCosta KA, Pomfret EA. Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver. J Biochem (Tokyo). 1989 May 1;259 (3):725-9.
23. Shields DJ, Lingrell S, Agellon LB, Brosnan JT, Vance DE. Localization independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase. J Biol Chem. 2005 Jul 22;280(29):27339-44.
24. Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE. Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem. 2003;278:5452-5.
25. Jacobs RL, Stead LM, Devlin C, Trabas I, Brosnan ME, Brosnan JT, Vance DE. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem. 2005;280:28299-305.
26. Innis SM, Davidson AGF, Chen A, Dyer RA, Melnyk S, James J. Increased plasma homocysteine and s-adenosylhomocysteine and decreased methionine is associated with altered phosphatidylcholine and phosphatidylethanolamine in cystic fibrosis. J Pediatr. 2003;143:351-6.
27. Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem. 2003;49:286-94.
28. Melnyk S, Pogribna M, Pogribny I, Hine RJ, James SJ. A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection. J Nutr Biochem. 1999;10:490-7.
29. Melnyk S, Pogribna M, Pogribny IP, Yi P, James SJ. Measurement of plasma and intracellular S-adenosylhomocysteine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal-5-phosphate levels. Clin Chem. 2000;46:265-72.
30. Zeisel SH, Da Costa K-A, Alexander EA, Lamont JT, Sheard NF, Beiser A. Choline, an essential nutrient for humans. FASEB J. 1991;5:2093-8.
31. Borowitz D, Baker RD, Stallings V. Consensus report on nutrition for pediatric patients with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2002;35:246-59.
32. Institute of Medicine. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acid. Washington, DC: National Academies Press, 2002; pp. 390-422.
33. Hoffman DR, Haning JA, Cornatze WE. Microsomal phosphatidylethanolamine methyltransferase:inhibition by S-adenosylhomocysteine. Lipids. 1981;16:561-7.
34. Benabdeslam H, Abidi H, Garcia I, Bellon G, Gilly R, Revol A. Lipid peroxidation and antioxidant defenses in cystic fibrosis patients. Clin Chem Lab Med. 1999;37:511-6.
35. Brown RK, Kelly FJ. Evidence for increased oxidative stress in patients with cystic fibrosis. Pediatr Res. 1994;36:487-93.
36. Winklhofer-Roob BM. Oxygen free radicals and antioxidants in cystic fibrosis: the concept of an oxidant-antioxidant imbalance. Acta Paediatr Suppl. 1994;83(395):49-57.
37. Lao JJ, Beyer K, Ariza A. The homocysteine pathway: a new target for Alzheimer disease treatment. Drug Dev Res. 2004;62:221-30.
38. Melse-Boonstra A, Holm PI, Meland PM, Olthof M, Clarke R, Verhoef P. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations. Am J Clin Nutr. 2005;81:1378-82.
39. Holm PI, Bleie O, Ueland PM, Lien EA, Refsum H, Nordrehaug JE, Nygard O. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation. Arterioscler Thromb Vasc Biol. 2004;24:301-7.
40. Molloy AM, Mills JL, Cox C, Daly SF, Conley M, Brody LC, Kirke PN, Scott JM, Ueland PM. Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. Am J Clin Nutr. 2005;82:836-42.
41. Wu G, Fang Y-Z, Yang S, Lupton J, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134:489-92.
42. Zou C-G, Banerjee R. Homocystiene and redox signaling. Antioxid Redox Signal. 2005;7:547-59.
43. Finkelstein JD, Lyle WE, Martin JJ, Pick AM. Activation of cystathionine β-synthase by adenosylmethionine and adensoylethionine. Biochem Biophys Res Commun. 1975;66:81-7.
44. Conway S. Osteoporosis in cystic fibrosis. J Cyst Fibros. 2003;2:161-2.
45. Rossini M, Del Marco A, Dal Santo F, Galti D, Braggion C, James G, Adami S. Prevalence and correlates of vertebral fractures in adults with cystic fibrosis. Bone. 2004;35:771-6.
46. Neugut AI, Jacobson JS, Suh S, Mukherjee R, Arber N. The epidemiology of cancer of the small bowel. Cancer Epidemiol Biomark Prev. 1988;7:243-51.
47. Griese M, Essl R, Schmidt R, Rietschel E, Ratjenm F, Ballmann M, Paul K, BEAT Study Group. Pulmonary userfactor, lung function, and endobronchial inflammation in cystic fibrosis. Am J Respir Crit Care Med. 2004;170:1000-5.
48. Ferarchak AP, Sokol RJ. Cholangiocyte biology and cystic fibrosis liver disease. Semin Liver Dis. 2001;21:471-88.