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Volumn 24, Issue 2, 2004, Pages 301-307

Betaine as a Determinant of Postmethionine Load Total Plasma Homocysteine before and after B-Vitamin Supplementation

Author keywords

Betaine; Folate; Homocysteine; Vitamin B12; Vitamin B6

Indexed keywords

BETAINE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHIONINE; METHYLTRANSFERASE; PLACEBO; PYRIDOXINE; VITAMIN B GROUP;

EID: 1042268029     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000114569.54976.31     Document Type: Article
Times cited : (53)

References (39)
  • 1
    • 0037164104 scopus 로고    scopus 로고
    • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
    • Clarke R, Collins R, Lewington S, Donald A, Alfthan G, Tuomilehto J. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015-2022.
    • (2002) JAMA , vol.288 , pp. 2015-2022
    • Clarke, R.1    Collins, R.2    Lewington, S.3    Donald, A.4    Alfthan, G.5    Tuomilehto, J.6
  • 2
    • 0004285329 scopus 로고    scopus 로고
    • Cambridge, New York, Melbourne. Madrid. Cape Town: Cambridge University Press
    • Carmel R, Jacobsen DW. Homocysteine Health and Disease. Cambridge, New York, Melbourne. Madrid. Cape Town: Cambridge University Press: 2001.
    • (2001) Homocysteine Health and Disease
    • Carmel, R.1    Jacobsen, D.W.2
  • 3
    • 0002500128 scopus 로고    scopus 로고
    • Determinants of plasma homocysteine
    • Robinson K. ed. Dordrecht, Boston. London: Kluwer Academic Publishers
    • Ueland PM, Refsum H, Schneede J. Determinants of plasma homocysteine. In: Robinson K. ed. Homosysteine and Vascular Disease. Dordrecht, Boston. London: Kluwer Academic Publishers; 2000.
    • (2000) Homosysteine and Vascular Disease
    • Ueland, P.M.1    Refsum, H.2    Schneede, J.3
  • 5
    • 0025362827 scopus 로고
    • Methionine metabolism in mammals
    • Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228-237.
    • (1990) J Nutr Biochem , vol.1 , pp. 228-237
    • Finkelstein, J.D.1
  • 6
    • 0028204930 scopus 로고
    • Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocystinemia in vascular patients
    • Franken DG, Boers GH, Blom HJ, Trijbels JM. Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocystinemia in vascular patients. J Inherit Metab Dis. 1994;17:159-162.
    • (1994) J Inherit Metab Dis , vol.17 , pp. 159-162
    • Franken, D.G.1    Boers, G.H.2    Blom, H.J.3    Trijbels, J.M.4
  • 7
    • 0031971439 scopus 로고    scopus 로고
    • Folic acid and Vitamin B6 supplementation and plasma homocysteine concentrations in healthy young women
    • Dierkes J, Kroesen M, Pietrzik K. Folic acid and Vitamin B6 supplementation and plasma homocysteine concentrations in healthy young women. Int J Vitam Nutr Res. 1998;68:98-103.
    • (1998) Int J Vitam Nutr Res , vol.68 , pp. 98-103
    • Dierkes, J.1    Kroesen, M.2    Pietrzik, K.3
  • 8
    • 0035076561 scopus 로고    scopus 로고
    • Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete
    • McKinley MC, McNulty H, McPartlin J, Strain JJ, Pentieva K, Ward M, Weir DG, Scott JM. Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr. 2001;73:759-764.
    • (2001) Am J Clin Nutr , vol.73 , pp. 759-764
    • McKinley, M.C.1    McNulty, H.2    McPartlin, J.3    Strain, J.J.4    Pentieva, K.5    Ward, M.6    Weir, D.G.7    Scott, J.M.8
  • 12
    • 0028220787 scopus 로고
    • Vitamin B-6 deficiency vs. folate deficiency: Comparison of responses to methionine loading in rats
    • Miller JW, Nadeau MR, Smith D, Selhub J. Vitamin B-6 deficiency vs. folate deficiency: comparison of responses to methionine loading in rats. Am J Clin Nutr. 1994;59:1033-1039.
    • (1994) Am J Clin Nutr , vol.59 , pp. 1033-1039
    • Miller, J.W.1    Nadeau, M.R.2    Smith, D.3    Selhub, J.4
  • 13
    • 0034234634 scopus 로고    scopus 로고
    • Choline: An essential nutrient for humans
    • Zeisel SH. Choline: An essential nutrient for humans. Nutrition. 2000;16:669-671.
    • (2000) Nutrition , vol.16 , pp. 669-671
    • Zeisel, S.H.1
  • 14
    • 0030904875 scopus 로고    scopus 로고
    • The natural history of vascular disease in homocystinuria and the effects of treatment
    • Wilcken DE, Wilcken B. The natural history of vascular disease in homocystinuria and the effects of treatment. J Inherit Metab Dis. 1997;20:295-300.
    • (1997) J Inherit Metab Dis , vol.20 , pp. 295-300
    • Wilcken, D.E.1    Wilcken, B.2
  • 15
    • 0034638064 scopus 로고    scopus 로고
    • Betaine supplementation and plasma homocysteine in healthy volunteers
    • Brouwer IA, Verhoef P, Urgen R. Betaine supplementation and plasma homocysteine in healthy volunteers. Arch Intern Med 2000;160:2546-2547.
    • (2000) Arch Intern Med , vol.160 , pp. 2546-2547
    • Brouwer, I.A.1    Verhoef, P.2    Urgen, R.3
  • 16
    • 1042301214 scopus 로고    scopus 로고
    • Effect of betaine on plasma concentrations of fasting and post-methionine loading homocysteine in healthy volunteers
    • Abstract 257. July 1-5. Sorrento, Naples
    • Steenge GR, Verhoef P, Olthof MR, Katan MB. Effect of betaine on plasma concentrations of fasting and post-methionine loading homocysteine in healthy volunteers. Abstract 257. 3rd International Conference on Homocysteine Metabolism, July 1-5. Sorrento, Naples. 2001.
    • (2001) 3rd International Conference on Homocysteine Metabolism
    • Steenge, G.R.1    Verhoef, P.2    Olthof, M.R.3    Katan, M.B.4
  • 17
    • 0036829164 scopus 로고    scopus 로고
    • Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects
    • Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa M. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002;76:961-967.
    • (2002) Am J Clin Nutr , vol.76 , pp. 961-967
    • Schwab, U.1    Torronen, A.2    Toppinen, L.3    Alfthan, G.4    Saarinen, M.5    Aro, A.6    Uusitupa, M.7
  • 18
    • 0037995375 scopus 로고    scopus 로고
    • Betaine supplementation lowers plasma homocysteine in healthy men and women
    • Steenge GR, Verhoef P, Katan MB. Betaine supplementation lowers plasma homocysteine in healthy men and women. J Nutr. 2003;133:1291-1295.
    • (2003) J Nutr , vol.133 , pp. 1291-1295
    • Steenge, G.R.1    Verhoef, P.2    Katan, M.B.3
  • 19
    • 0027198477 scopus 로고
    • Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology
    • Dudman NP, Wilcken DE, Wang J, Lynch JF, Macey D, Lundberg P. Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology. Arterioscler. Thromb. 1993;13:1253-1260.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1253-1260
    • Dudman, N.P.1    Wilcken, D.E.2    Wang, J.3    Lynch, J.F.4    Macey, D.5    Lundberg, P.6
  • 20
    • 0036189383 scopus 로고    scopus 로고
    • Betaine supplementation decreases post-methionine hyperhomocystinemia in chronic renal failure
    • McGregor DO, Dellow WJ, Robson RA, Lever M, George PM, Chambers ST. Betaine supplementation decreases post-methionine hyperhomocystinemia in chronic renal failure. Kidney Int. 2002;61:1040-1046.
    • (2002) Kidney Int , vol.61 , pp. 1040-1046
    • McGregor, D.O.1    Dellow, W.J.2    Robson, R.A.3    Lever, M.4    George, P.M.5    Chambers, S.T.6
  • 22
    • 0037307164 scopus 로고    scopus 로고
    • Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry
    • Hohn PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem. 2003;49:286-294.
    • (2003) Clin Chem , vol.49 , pp. 286-294
    • Hohn, P.I.1    Ueland, P.M.2    Kvalheim, G.3    Lien, E.A.4
  • 23
    • 0344352486 scopus 로고    scopus 로고
    • Chloroformates in gas chromatography as general purpose derivatizing agents
    • Husek P. Chloroformates in gas chromatography as general purpose derivatizing agents. J Chromatogr B Biomed Sci Appl. 1998;717:57-91.
    • (1998) J Chromatogr B Biomed Sci Appl , vol.717 , pp. 57-91
    • Husek, P.1
  • 24
    • 0025860071 scopus 로고
    • Microbiological assay for vitamin B12 performed in 96-well microtitre plates
    • Kelleher BP, Broin SD. Microbiological assay for vitamin B12 performed in 96-well microtitre plates. J Clin Pathol. 1991;44:592-595.
    • (1991) J Clin Pathol , vol.44 , pp. 592-595
    • Kelleher, B.P.1    Broin, S.D.2
  • 25
    • 0026544977 scopus 로고
    • Microbiological assay on microtitre plates of folate in serum and red cells
    • O'Broin S, Kelleher B. Microbiological assay on microtitre plates of folate in serum and red cells. J Clin Pathol. 1992;45:344-347.
    • (1992) J Clin Pathol , vol.45 , pp. 344-347
    • O'Broin, S.1    Kelleher, B.2
  • 28
    • 0027515431 scopus 로고
    • Serum betaine N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism
    • Allen RH, Stabler SP, Lindenbaum J. Serum betaine N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism. 1993;42:1448-1460.
    • (1993) Metabolism , vol.42 , pp. 1448-1460
    • Allen, R.H.1    Stabler, S.P.2    Lindenbaum, J.3
  • 30
    • 0033583210 scopus 로고    scopus 로고
    • Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene
    • Park EI, Garrow TA. Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. J Biol Chem. 1999;274:7816-7824.
    • (1999) J Biol Chem , vol.274 , pp. 7816-7824
    • Park, E.I.1    Garrow, T.A.2
  • 31
    • 0017572583 scopus 로고
    • Free choline in human plasma analysed by simple radio-enzymatic procedure: Age distribution and effect of a meal
    • Eckernas SA, Aquilonius SM. Free choline in human plasma analysed by simple radio-enzymatic procedure: age distribution and effect of a meal. Scand J Clin Lab Invest. 1977;37:183-187.
    • (1977) Scand J Clin Lab Invest , vol.37 , pp. 183-187
    • Eckernas, S.A.1    Aquilonius, S.M.2
  • 32
    • 0030814518 scopus 로고    scopus 로고
    • Prolonged fasting in humans results in diminished plasma choline concentrations but does not cause liver dysfunction
    • Savendahl L, Mar MH, Underwood LE, Zeisel SH. Prolonged fasting in humans results in diminished plasma choline concentrations but does not cause liver dysfunction. Am J Clin Nutr. 1997;66:622-625.
    • (1997) Am J Clin Nutr , vol.66 , pp. 622-625
    • Savendahl, L.1    Mar, M.H.2    Underwood, L.E.3    Zeisel, S.H.4
  • 33
    • 0034999383 scopus 로고    scopus 로고
    • Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations
    • McGregor DO, Dellow WJ, Lever M, George PM, Robson RA, Chambers ST. Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations. Kidney Int. 2001;59:2267-2272.
    • (2001) Kidney Int , vol.59 , pp. 2267-2272
    • McGregor, D.O.1    Dellow, W.J.2    Lever, M.3    George, P.M.4    Robson, R.A.5    Chambers, S.T.6
  • 34
    • 0020572775 scopus 로고
    • Homocystinuria: The effects of betaine in the treatment of patients not responsive to pyridoxine
    • Wilcken DEL, Wilcken B, Dudman NPB, Tyrrell P. A. Homocystinuria: the effects of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med. 1983;309:448-453.
    • (1983) N Engl J Med , vol.309 , pp. 448-453
    • Wilcken, D.E.L.1    Wilcken, B.2    Dudman, N.P.B.3    Tyrrell, P.A.4
  • 35
    • 0021267379 scopus 로고
    • Betaine in the treatment of homocystinuria due to 5, 10-methyleneletrahydrofolate reductase deficiency
    • Wendel U, Bremer HJ. Betaine in the treatment of homocystinuria due to 5, 10-methyleneletrahydrofolate reductase deficiency. Eur J Pediatr. 1984;142:147-150.
    • (1984) Eur J Pediatr , vol.142 , pp. 147-150
    • Wendel, U.1    Bremer, H.J.2
  • 36
    • 0024359963 scopus 로고
    • Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency
    • Holme E, Kjellman B, Ronge E. Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency. Arch Dis Child. 1989;64:1061-1064.
    • (1989) Arch Dis Child , vol.64 , pp. 1061-1064
    • Holme, E.1    Kjellman, B.2    Ronge, E.3
  • 37
    • 0029780854 scopus 로고    scopus 로고
    • Hepatic betaine-homocysteine methyltransferase activity in the chicken is influenced by dietary intake of sulfur amino acids, choline and betaine
    • Emmert JL, Garrow TA, Baker DH. Hepatic betaine-homocysteine methyltransferase activity in the chicken is influenced by dietary intake of sulfur amino acids, choline and betaine. J Nutr. 1996;126:2050-2058.
    • (1996) J Nutr , vol.126 , pp. 2050-2058
    • Emmert, J.L.1    Garrow, T.A.2    Baker, D.H.3
  • 38
    • 0030764090 scopus 로고    scopus 로고
    • Diet-induced changes in hepatic betaine-homocysteine methyltransferase activity are mediated by changes in the steady-state level of its mRNA
    • Park EI, Renduchintala MS, Garrow TA. Diet-induced changes in hepatic betaine-homocysteine methyltransferase activity are mediated by changes in the steady-state level of its mRNA. J Nutr Biochem. 1997;8:541-545.
    • (1997) J Nutr Biochem , vol.8 , pp. 541-545
    • Park, E.I.1    Renduchintala, M.S.2    Garrow, T.A.3
  • 39
    • 0031989155 scopus 로고    scopus 로고
    • Hepatic and renal betaine-homocysteine methyltransferase activity in pigs as affected by dietary intakes of sulfur amino acids, choline, and betaine
    • Emmert JL, Webel DM, Biehl RR, Griffiths MA, Garrow LS, Garrow TA, Baker DH. Hepatic and renal betaine-homocysteine methyltransferase activity in pigs as affected by dietary intakes of sulfur amino acids, choline, and betaine. J Animal Sci. 1998;76:606-610.
    • (1998) J Animal Sci , vol.76 , pp. 606-610
    • Emmert, J.L.1    Webel, D.M.2    Biehl, R.R.3    Griffiths, M.A.4    Garrow, L.S.5    Garrow, T.A.6    Baker, D.H.7


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