Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 14, 2006, Pages 3740-3744

  Thomas, Sheela A ^a   Li, Tongmei ^a   Woods, Keith W ^a   Song, Xiaohong ^a   Packard, Garrick ^a   Fischer, John P ^a   Diebold, Robert B ^a   Liu, Xuesong ^a   Shi, Yan ^a   Klinghofer, Vered ^a   Johnson, Eric F ^a   Bouska, Jennifer J ^a   Olson, Amanda ^a   Guan, Ran ^a   Magnone, Shayna R ^a   Marsh, Kennan ^a   Luo, Yan ^a   Rosenberg, Saul H ^a   Giranda, Vincent L ^a   Li, Qun ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

3,5 Disubstituted pyridines; AKT inhibitors; AKT PKB

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; EVALUATION; HUMAN; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; ENZYME INHIBITORS; MICE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746574515     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.046     Document Type: Article

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