Effect of mycophenolate mofetil on rat kidney grafts with prolonged cold preservation

Kidney International

Volumn 70, Issue 3, 2006, Pages 570-577

  Fuller, T F ^a   Hoff, U ^a   Rose, F ^a   Linde, Y ^a   Freise, C E ^b   Dragun, D ^a   Feng, S ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Kidney transplantation; MMF; Preservation injury; Rat

Indexed keywords

CD3 ANTIGEN; CREATININE; CYCLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CELL REGENERATION; COLD PRESERVATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRYOPRESERVATION; DISEASE SEVERITY; DOSE RESPONSE; GRAFT REJECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY DONOR; KIDNEY FAILURE; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; KIDNEY TUBULE CELL; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL; TISSUE PRESERVATION;

ANIMALS; CELL DIVISION; CHEMOKINE CCL2; CREATININE; CRYOPRESERVATION; GRAFT REJECTION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; MACROPHAGES; MALE; MYCOPHENOLIC ACID; NEPHRITIS; RATS; RATS, INBRED LEW; SURVIVAL RATE; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33746574402     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5001591     Document Type: Article

References (34)

1. Tullius SG, Volk HD, Neuhaus P. Transplantation of organs from marginal donors. Transplantation 2001; 72: 1341-1349.
2. Ojo AO, Wolfe RA, Held PJ et al. Delayed graft function: risk factors and implications for renal allograft survival. Transplantation 1997; 63: 968-974.
3. Wigmore SJ, Seeney FM, Pleass HC et al. Kidney damage during organ retrieval: data from UK National Transplant Database. Kidney Advisory Group. Lancet 1999; 354: 1143-1146.
4. Remuzzi G, Perico N. Cyclosporine-induced renal dysfunction in experimental animals and humans. Kidney Int 1995; 52: S70-S74.
5. McCauley J. The nephrotoxicity of FK506 as compared with cyclosporine. Curr Opin Nephrol Hypertens 1993; 2: 662-669.
6. Hortelano S, Castilla M, Torres AM et al. Potentiation by nitric oxide of cyclosporin A and FK506-induced apoptosis in renal proximal tubule cells. J Am Soc Nephrol 2000; 11: 2315-2323.
7. Lieberthal W, Fuhro R, Andry CC et al. Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 2001; 281: F693-F706.
8. Fuller TF, Freise CE, Serkova N et al. Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury. Transplantation 2003; 76: 1594-1599.
9. McTaggart RA, Gottlieb D, Brooks J et al. Sirolimus prolongs recovery from delayed graft function after cadaveric renal transplantation. Am J Transplant 2003; 3: 416-423.
10. Smith KD, Wrenshall LE, Nicosia RF et al. Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use. J Am Soc Nephrol 2003; 14: 1037-1045.
11. Ventura CG, Coimbra TM, de Campos SB et al. Mycophenolate mofetil attenuates renal ischemia/reperfusion injury. J Am Soc Nephrol 2002; 13: 2524-2533.
12. Ysebaert DK, De Greef KE, Vercauteren SR et al. Effect of immunosuppression on damage, leukocyte infiltration, and regeneration after severe warm ischemia/reperfusion renal injury. Kidney Int 2003; 64: 864-873.
13. Eugui EM, Mirkovich A, Allison AC. Lymphocyte-selective antiproliferative and immunosuppressive activity of mycophenolic acid and its morpholinoethyl ester (RS-61443) in rodents. Transplant Proc 1991; 23: 15-18.
14. Rosen S, Heyman SN. Difficulties in understanding human 'acute tubular necrosis': limited data and flawed animal models. Kidney Int 2001; 60: 1220-1224.
15. Nadasdy T, Laszik Z, Blick KE et al. Human acute tubular necrosis: a lectin and immunohistochemical study. Hum Pathol 1995; 26: 230-239.
16. Barten MJ, van Gelder T, Gummert JF et al. Pharmacodynamics of mycophenolate mofetil after heart transplantation: new mechanisms of action and correlations with histologic severity of graft rejection. Am J Transplant 2002; 2: 719-732.
17. Dragun D, Hoff U, Park JK et al. Prolonged cold preservation augments vascular injury independent of renal transplant immunogenicity and function. Kidney Int 2001; 60: 1173-1181.
18. Dragun D, Hoff U, Park JK et al. Ischemia-reperfusion injury in renal transplantation is independent of the immunologic background. Kidney Int 2000; 58: 2166-2177.
19. Hauet T, Goujon J-M, Vanderwalle A et al. Trimetazidine reduces renal dysfunction by limiting the cold ischemia/reperfusion injury in autotransplanted pig kidneys. J Am Soc Nephrol 2000; 11: 138-148.
20. Matejka GL, Jennische E. IGF-I binding and IGF-I mRNA expression in the post-ischemic regenerating rat kidney. Kidney Int 1992; 42: 1113-1123.
21. Humes HD. Potential molecular therapy for acute renal failure. Cleve Clin J Med 1993; 60: 166-168.
22. Kluth DC, Erwig LP, Rees AJ. Multiple facets of macrophages in renal injury. Kidney Int 2004; 66: 542-557.
23. Burne-Taney MJ, Rabb H. The role of adhesion molecules and T cells in ischemic renal injury. Curr Opin Nephrol Hypertens 2003; 12: 85-90.
24. Gonzalez N, Alvarez V, Pons H et al. Mycophenolate mofetil aggravates postischemic acute renal failure in rats. Transplant Proc 2002; 34: 43-44.
25. Sun DF, Fujigaki Y, Fujimoto T et al. Mycophenolate mofetil inhibits regenerative repair in uranyl acetate-induced acute renal failure by reduced interstitial cellular response. Am J Pathol 2002; 161: 217-227.
26. Viklicky O, Bohmova R, Ouyang N et al. Effect of sirolimus on renal ischaemia/reperfusion injury in normotensive and hypertensive rats. Transplant Int 2004; 17: 432-441.
27. Vercauteren SR, Ysebaert DK, Van Rompay AR et al. Acute ischemia/reperfusion injury after isogeneic kidney transplantation is mitigated in a rat model of chronic renal failure. Am J Transplant 2003; 3: 570-580.
28. Forbes JM, Leaker B, Hewitson TD et al. Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists. Kidney Int 1999; 55: 198-208.
29. Oliver JA, Maarouf O, Cheema FH et al. The renal papilla is a niche for adult kidney stem cells. J Clin Invest 2004; 114: 795-804.
30. Sharma K, Ziyadeh FN. The emerging role of transforming growth factor-beta in kidney diseases. Am J Physiol 1994; 266: F829-F842.
31. Basile DP, Rovak JM, Martin DR et al. Increased transforming growth factor-beta 1 expression in regenerating rat renal tubules following ischemic injury. Am J Physiol 1996; 270: F500-F509.
32. Rice JC, Spence JS, Yetman DL et al. Monocyte chemoattractant protein-1 expression correlates with monocyte infiltration in the post-ischemic kidney. Renal Fail 2002; 24: 703-723.
33. Cho YW, Cecka JM, Gjertson DW et al. Prolonged hypertension (410 years) is a significant risk factor in older cadaver donor renal transplants. Transplant Proc 1999; 31: 1283.
34. Fisher B, Lee S. Microvascular surgical technique in research with special reference to renal transplantation in the rat. Surgery 1965; 58: 904.