Ca2+ antagonist and cholinergic activities explain the medicinal use of olive in gut disorders

Nutrition Research

Volumn 26, Issue 6, 2006, Pages 277-283

  Gilani, Anwarul Hassan ^a   Khan, Arif ullah ^a   Ghayur, Muhammad Nabeel ^a  

^a AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

Author keywords

Calcium antagonist; Cholinergic; Olive; Rabbit jejunum; Spasmogenic; Spasmolytic

Indexed keywords

ATROPINE; CALCIUM ANTAGONIST; OLEA EUROPEA FRUIT EXTRACT; PLANT EXTRACT; POTASSIUM; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CALCIUM ANTAGONISM; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; EXTRACTION; FEMALE; FRACTIONATION; GASTROINTESTINAL MOTILITY DISORDER; IN VITRO STUDY; JEJUNUM; MALE; MEDICINAL PLANT; MUSCLE EXCITATION; MUSCLE RELAXATION; NONHUMAN; OLIVE; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; SPASMOLYSIS;

OLEA EUROPAEA; OLEACEAE; ORYCTOLAGUS CUNICULUS;

EID: 33746488361     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2006.06.009     Document Type: Article

References (24)

1. Nadkarni K.M. Indian materia medica. 3rd ed. (1976), Popular Prakashan, Bombay 870
2. Usmanghani K., Saeed A., and Alam M.T. Indusyunic medicine (1997), Karachi University Press, Karachi 314
3. Ziyyat A., Legssyr A., Mekhfi H., Dassouli A., Serhrouchni M., and Benjenlloun W. Phytotherapy of hypertension and diabetes in oriental Morocco. J Ethnopharmacol 58 (1997) 45-54
4. Wyk B.V., Oudtshoorn B.V., and Gericke N. Medicinal plants of South Africa (2002), Briza Publications, Pretoria 154
5. Duke J.A. Handbook of phytochemical constituents of GRAS herbs and other economical plants (1992), CRC Press, London 412
6. Chowdhury B., Bhattacharyya D., and Mukhopadhyay S. Antimicrobial effect of some simple and complex phenolic compounds of olive fruits against pathogenic bacteria. Biomed Lett 54 (1996) 45-49
7. Keys A. Olive oil and coronary heart diseases. Lancet 1 (1987) 938-984
8. Gonzalez M., Zarzuelo A., Gamez M.J., Utrilla M.P., Jiménez J., and Osuna I. Hypoglycemic activity of olive leaf. Planta Med 58 (1992) 513-515
9. Pinelli P., Galardi C., Mulinacci N., Vincieri F.F., Tattini M., and Romani A. Quali-quantitative analysis and antioxidant activity of different polyphenolic extracts from Olea europea leaves. J Com Sci 39 (2000) 71-83
10. De Pasquale R., Monforte M.T., Trozzi A., Raccuia A., Tommasini S., and Ragusa S. Effects of leaves and shoots of Olea europea and oleuropein on experimental hypercholesterolemia in rat. Plant Medicinal Phytother 25 (1991) 134-140
11. Lasserre B., Kaiser R., Pham H.C., Ifansyah N., Gleye J., and Moulis C. Effect on rats of aqueous extracts of plants used in folk medicine as antihypertensive agents. Naturwissenschaften 70 (1983) 95-96
12. Zarzuelo A., Duarte J., Jimenez J., Gonzalez M., and Utrilla M.P. Vasodilator effect of olive leaf. Planta Med 57 (1991) 417-419
13. Tona L., Kambu K., Ngimbi N., Cimanga K., and Vlietinck A.J. Antiamoebic and phytochemical screening of some Congolese medicinal plants. J Ethnopharmacol 61 (1998) 57-65
14. Gilani A.H., Aziz N., Khuram I.M., Rao Z.A., and Ali B.A. The presence of cholinomimetic and calcium channel antagonist constituents in Piper betle. Phytother Res 14 (2000) 436-442
15. ++ antagonists. Gen Pharmacol 22 (1991) 177-181
16. Bolton T.B. Mechanism of action of transmitter and other substances on smooth muscles. Physiol Rev 59 (1979) 606-718
17. Godfraind T., Miller R., and Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 38 (1986) 312-416
18. ++ in myocardium, cardiac pacemakers and vascular smooth muscle. Rev Pharmacol Toxicol 17 (1977) 149-166
19. Triggle D.J. Drug effecting calcium-regulation and actions. In: Smith G.M., and Reynard A.M. (Eds). Textbook of pharmacology (1992), WB Saunders, Philadelphia 453-479
20. Cohen S., and Snape W.J.J. Movement of the small and large intestine. In: Sleisenger M.H., and Fordtran J.S. (Eds). Gastrointestinal diseases, pathophysiology, diagnosis and management. 4th ed. (1989), W B Saunders, Philadelphia 1088-1105
21. Brunton L.L. Agents effecting gastrointestinal water flux and motility; emesis and antiemetics; bile acids and pancreatic enzymes. In: Hardman J.G., Limbird L.E., Molinoff P.B., Ruddon R.W., and Gilman A.G. (Eds). Goodman and Gillman's the pharmacological basis of therapeutics (1996), McGraw Hill, New York 917-936
22. Gilani A.H., Shaheen F., Christopoulos A., and Mitchelson F. Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscarinic acetylcholine receptor subtypes. Life Sci 60 (1997) 535-544
23. 2. Gen Pharmacol 29 (1997) 847-857
24. Gilani A.H., Aftab K., and Ahmed S. Cholinergic actions of crude saponins from Castanospermum australe. Int J Pharm 32 (1994) 209-216