The effect of atorvastatin on cerebral vasospasm after subarachnoid hemorrhage in rats

Chinese Journal of Cerebrovascular Diseases

Volumn 3, Issue 7, 2006, Pages 307-311

  Chen, Xiao Guang ^a   Li, Xiao Jie ^b  

^a HEILONGJIANG PROVINCIAL HOSPITAL   (China)

^b NONE

Author keywords

Atorvastatin; Inflammation; Rats; Subarachnoid hemorrhage; Vasospasm, intracranial

Indexed keywords

ATORVASTATIN; EOSIN; HEMATOXYLIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 6; LIPID; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MESSENGER RNA; SODIUM CHLORIDE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERY DIAMETER; ARTICLE; BASILAR ARTERY; BRAIN FUNCTION; BRAIN HEMORRHAGE; BRAIN VASOSPASM; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNCTIONAL ASSESSMENT; IMAGE ANALYSIS; LIPID BLOOD LEVEL; MALE; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RANDOMIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; STAINING; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

EID: 33746482810     PISSN: 16725921     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Dumont AS, Dumont RJ, Chow MM, et al. Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation. Neurosurgery, 2003, 53: 123-135.
2. Palinski W, Tsimikas S. Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis. J Am Soc Nephrol, 2002, 13: 1673-1681.
3. Vaughan CJ, Delanty N. Neuroprotective properties of statins in cerebral ischemia and stroke. Stroke, 1999, 30: 1969-1973.
4. Prunell GF, Mathiesen T, Diemer NH, et al. Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models. Neurosurgery, 2003, 52: 165-176.
5. McGirt MJ, Lynch JR, Parra A. Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke, 2002, 33: 2950-2956.
6. Singhal AB, Topcuoglu MA, Dorer DJ, et al. SSRI and statin use increases the risk for vasospasm after subarachnoid hemorrhage. Neurology, 2005, 64: 1008-1013.
7. Parra A, Kreiter K, Williams S, et al. Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study. Neurosurgery, 2005, 56: 476-484.
8. Sills AK Jr, Clatterbuck RE, Thompson RC, et al. Endothelial cell expression of intercellular adhesion molecule 1 in experimental posthemorrhagic vasospasm. Neurosurgery, 1997, 41: 453461.
9. Clatterbuck RE, Gailloud P, Ogata L, et al. Prevention of cerebral vasospasm by a humanized anti-CD11/CD18 monoclonal antibody administered after experimental subarachnoid hemorrhage in nonhuman primates. J Neurosurg, 2003, 99: 376-382.
10. Fassbender K, Hodapp B, Rossol S, et al. Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries. J Neurol Neurosurg Psychiatry, 2001, 70: 534-537.
11. Hirashima Y, Nakamura S, Endo S, et al. Elevation of platelet activating factor, inflammatory cytokine, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. Neurochem Res, 1997, 22: 1249-1255.
12. Reiter CD, Gladwin MT. A emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy. Curr Opin Hematol, 2003, 10: 99-107.
13. Taddei S, Virdis A, Ghiadoni L, et al. The role of endothelium in human hypertension. Curr Opin Nephrol Hypertens, 1998, 7: 203-209.