Pathogenesis of bone disease in cystic fibrosis: The role of bone size and sarcopenia

Journal of the Royal Society of Medicine, Supplement

Volumn 99, Issue 46, 2006, Pages 2-5

  Mughal, Zulf ^a   Sood, Manu ^b   Ward, Kate A ^c   Adams, Judith E ^c  

^a ST MARY S HOSPITAL   (United Kingdom)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BODY MASS; BONE DENSITY; BONE DEVELOPMENT; BONE DISEASE; BONE MASS; BONE STRENGTH; BREATHING EXERCISE; CONFERENCE PAPER; CYSTIC FIBROSIS; DISEASE ASSOCIATION; FRAGILITY FRACTURE; HUMAN; KYPHOSIS; LUNG CLEARANCE; LUNG FUNCTION; MUSCLE ATROPHY; PATHOGENESIS; RIB FRACTURE; THORAX PAIN;

ADOLESCENT; ADULT; BONE AND BONES; BONE DENSITY; CYSTIC FIBROSIS; FRACTURES, BONE; HUMANS; MUSCULAR ATROPHY;

EID: 33746477480     PISSN: 02675331     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (51)

1. Elkin SL, Fairney A, Burnett S, et al. Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a cross-sectional study. Osteoporos Int 2001;12:366-72
2. Aris RM, Renner JB, Winders AD, et al. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann Intern Med 1988;128:186-93
3. Aris RM, Merkel PA, Bachrach LK, et al. Consensus Conference Report: Guide to bone health and disease in cystic fibrosis. J Clin Endocrinol Metab 2005;90:1888-96
4. Henderson RC, Specter BB. Kyphosis and fractures in children and young adults with cystic fibrosis. J Pediatr 1994;125:208-12
5. Latzin P, Griese M, Hermanns V, et al. Sternal fracture with fatal outcome in cystic fibrosis. Thorax 2005;60:616
6. Frost HM. On our age-related bone loss: insights from a new paradigm. J Bone Miner Res 1997;12:1539-46
7. Augat P, Reeb H, Claes LE. Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J Bone Miner Res 1996;11:1356-63
8. Ward KA, Caulton JM, Adams JE, et al. Perspective: cerebral palsy as a model of bone development in the absence of postnatal mechanical factors. J Musculoskel Interact (in press)
9. Weinstein RS. True strength. J Bone Miner Res 2000;15:621-5
10. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996;312:1254-9
11. Kanis JA, Gluer CC. An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation. Osteoporos Int 2000;11:192-202
12. Goulding A, Jones IE, Taylor RW, Manning PJ, Williams SM. More broken bones: a 4-year double cohort study of young girls with and without distal forearm fractures. J Bone Miner Res 2000;15:2011-18
13. Haworth CS, Selby PL, Webb AK, et al. Low bone mineral density in adults with cystic fibrosis. Thorax 1999;54:961-7
14. Bachrach LK, Loutit CW, Moss RB. Osteopenia in adults with cystic fibrosis. Am J Med 1994;96:27-34
15. Grey AB, Ames RW, Matthews RD, et al. Bone mineral density and body composition in adult patients with cystic fibrosis. Thorax 1993;48:589-93
16. Shaw N, Bedford C, Heaf D, et al. Osteopenia in adults with cystic fibrosis. Am J Med 1995;99:690-2
17. Conway SP, Morton AM, Oldroyd B, et al. Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax 2000;55:798-804
18. Henderson RC, Madsen CD. Bone density in children and adolescents with cystic fibrosis. J Pediatr 1996;128:28-34
19. Bhudhikanok GS, Lim J, Marcus R, et al. Correlates of osteopenia in patients with cystic fibrosis. Pediatrics 1996;97:103-11
20. Bhudhikanok GS, Wang M-C, Marcus R, et al. Bone acquisition and loss in children and adults with cystic fibrosis: a longitudinal study. J Pediatr 1998;133:18-27
21. Baroncelli GI, De Luca F, Magazzu G, et al. Bone demineralization in cystic fibrosis: evidence of imbalance between bone formation and degradation. Pediatr Res 1997;41:397-403
22. Sood M, Hambleton G, Super M, et al. Bone status in cystic fibrosis. Arch Dis Child 2001;84:516-20
23. Salamoni F, Roulet M, Gudinchet F, et al. Bone mineral content in cystic fibrosis patients: correlation with fat-free mass. Arch Dis Child 1996;74:314-18
24. Hardin DS, Arumugam R, Seilheimer DK, LeBlanc A, Ellis KJ. Normal bone mineral density in cystic fibrosis. Arch Dis Child 2001;84:363-8
25. Mortensen LA, Chan GM, Alder SC, et al. Bone mineral status in prepubertal children with cystic fibrosis. J Pediatr 2000;136:648-52
26. Buntain HM, Greer RM, Schluter PJ, et al. Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax 2004;59:149-55
27. King SJ, Topliss DJ, Kotsimbos T, et al. Reduced bone density in cystic fibrosis: ΔF508 mutation is an independent risk factor. Eur Respir J 2004;25:54-61
28. Aris RM, Neuringer IP, Weiner MA, Egan TM, Ontjes D. Severe osteoporosis before and after lung transplantation. Chest 1996;109:1176-83
29. Reiter EO, Stern RC, Root AW. The reproductive endocrine system in cystic fibrosis: changes in gonadotrophins and sex steroids following LHRH. Clin Endocrinol 1982;16:127-37
30. Landon C, Rosenfeld RG. Short stature and pubertal delay in cystic fibrosis. Pediatrics 1987;14:253-60
31. Levin ME, Boisseau VC, Avioli LV. Effects of diabetes mellitus on bone mass in juvenile and adult-onset diabetes. N Engl J Med 1976;294:241-5
32. Schulze KJ, O'Brien KO, Germain-Lee EL, et al. Calcium kinetics are altered in clinically stable girls with cystic fibrosis. J Clin Endocrinol Metab 2004;89:3385-91
33. Donovan DS, Papadopoulos A, Staron RB, et al. Bone mass and vitamin D deficiency in adults with advanced cystic fibrosis lung disease. Am J Respir Crit Care Med 1998;158:1892-9
34. Lark RK, Lester GE, Ontjes DA, et al. Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. Am J Clin Nutr 2001;73:602-6
35. Wilson DC, Rashid M, Durie PR, et al. Treatment of vitamin K deficiency in cystic fibrosis: effectiveness of a daily fat-soluble vitamin combination. J Pediatr 2001;138:851-5
36. Aris RM, Stephens AR, Ontjes DA, et al. Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. Am J Respir Crit Care Med 2000;162:1674-8
37. Prentice A, Parsons TJ, Cole TJ. Uncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants. Am J Clin Nutr 1994;60:837-42
38. Haeusler G, Frisch H, Waldhor T, et al. Perspectives of longitudinal growth in cystic fibrosis from birth to adult age. Eur J Pediatr 1994;153:158-63
39. Laursen EM, Molgaard C, Michaelsen KF, et al. Bone mineral status in 134 patients with cystic fibrosis. Arch Dis Child 1999;81:235-40
40. Mølgaard C, Thomsen BL, Prentice A, et al. Whole body bone mineral content in healthy children and adolescents. Arch Dis Child 1997;76:9-15
41. Sood M, Adams JE, Mughal MZ. Lean body mass in children with cystic fibrosis. Arch Dis Child 2003;88:836
42. Stallings VA, Tomezsko JL, Schall JI, et al. Adolescent development and energy expenditure in females with cystic fibrosis. Clin Nutr 2005;24:737-45
43. Elkin SL, Williams L, Moore M, et al. Relationship of skeletal muscle mass, muscle strength and bone mineral density in adults with cystic fibrosis. Clin Sci (Lond) 2000;99:309-14
44. Pinet C, Cassart M, Scillia P, et al. Function and bulk of respiratory and limb muscles in patients with cystic fibrosis. Am J Respir Crit Care Med 2003;168:989-94
45. Ionescu AA, Nixon LS, Luzio S, et al. Pulmonary function, body composition, and protein catabolism in adults with cystic fibrosis. Am J Respir Crit Care Med 2002;165:495-500
46. Ionescu AA, Nixon LS, Evans WD, et al. Bone density, body composition and inflammatory status in cystic fibrosis. Am J Respir Crit Care Med 2000;162:789-94
47. Sermet-Gaudelus I, Souberbielle JC, Azhar I, et al. Insulin-like growth factor I correlates with lean body mass in cystic fibrosis patients. Arch Dis Child 2003;88:956-61
48. Ward KA, Roberts SA, Adams J, et al. Peripheral and axial skeletal adaptation to high intensity exercise: a study of gymnasts and school children. Bone 2005;36:1012-18
49. Rubin C, Turner S, Bain S, Mallinckrodt C, McLeod K. Low mechanical signals strengthen long bones. Nature 2001;412:603-4.
50. Rubin C, Xu G, Judex S. The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low magnitude mechanical stimuli. FASEB J 2001;15:2225-9
51. Ward KA, Alsop CW, Caulton JM, et al. Low magnitude, high frequency loading therapy increases volumetric trabecular tibial bone mineral density in children with disabling conditions. J Bone Miner Res 2004;19:360-9