Consensus statement: Guide to bone health and disease in cystic fibrosis

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 3, 2005, Pages 1888-1896

  Aris, Robert M ^a,n   Merkel, Peter A ^b   Bachrach, Laura K ^c   Borowitz, Drucy S ^d   Boyle, Micheal P ^e   Elkin, Sarah L ^g   Guise, Theresa A ^h   Hardin, Dana S ⁱ   Haworth, Charles S ^j   Holick, Michael F ^b   Joseph, Patricia M ^k   O'Brien, Kimberly ^f   Tullis, Elizabeth ^l   Watts, Nelson B ^k   White, Terry B ^m  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY AT BUFFALO   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f JOHNS HOPKINS UNIVERSITY   (United States)

^g ROYAL BROMPTON HOSPITAL   (United Kingdom)

^h UNIVERSITY OF VIRGINIA   (United States)

ⁱ UNIVERSITY OF TEXAS AT DALLAS   (United States)

^j Manchester Adult CF Unit   (United Kingdom)

^k UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^l UNIVERSITY OF TORONTO   (Canada)

^m CYSTIC FIBROSIS FOUNDATION   (United States)

ⁿ UNIVERSITY OF NORTH CAROLINA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; ANABOLIC AGENT; ANTIBIOTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CALCIFEDIOL; CALCITRIOL; CALCIUM; COLECALCIFEROL; CYTOKINE; ERGOCALCIFEROL; ESTROGEN; FAT; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; PAMIDRONIC ACID; PANCREAS ENZYME; PARATHYROID HORMONE; PREDNISONE; RECOMBINANT GROWTH HORMONE; RISEDRONIC ACID; SEX HORMONE; TESTOSTERONE ENANTATE; TRANSMEMBRANE CONDUCTANCE REGULATOR; VITAMIN D DERIVATIVE; VITAMIN K GROUP; ZOLEDRONIC ACID;

BODY MASS; BONE BIOPSY; BONE DENSITY; BONE DISEASE; BONE MASS; BONE PAIN; BONE TURNOVER; CAUCASIAN; CHRONIC LUNG DISEASE; CLINICAL TRIAL; CONFERENCE PAPER; CONSENSUS; CYSTIC FIBROSIS; DELAYED PUBERTY; DIABETES MELLITUS; DISORDERS OF CARBOHYDRATE METABOLISM; DRUG SAFETY; ENZYME REPLACEMENT; ESOPHAGITIS; ESOPHAGUS VARICES; EUROPE; FEMUR FRACTURE; FEVER; FORCED EXPIRATORY VOLUME; FRACTURE; GASTROESOPHAGEAL REFLUX; GENE MUTATION; GENETIC DISORDER; GROWTH DISORDER; HEALTH HAZARD; HORMONE SYNTHESIS; HUMAN; HYPOGONADISM; HYPOTHALAMUS DISEASE; IMMOBILIZATION; INSULIN RESISTANCE; KYPHOSIS; LIFESPAN; LIPID ABSORPTION; LIPID SOLUBILITY; LIVER CIRRHOSIS; LONG TERM CARE; LUNG GRAFT REJECTION; LUNG INFECTION; LUNG TRANSPLANTATION; MALNUTRITION; MOTIVATION; NORTH AMERICA; OBSERVATION; OSTEOLYSIS; OSTEOMALACIA; OSTEOMETRY; OSTEOPENIA; OSTEOPOROSIS; PANCREAS INSUFFICIENCY; PANCREAS ISLET CELL; PATHOGENESIS; PHLEBITIS; PHOTOSENSITIVITY; PHYSIOTHERAPY; POPULATION; POSTOPERATIVE COMPLICATION; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITY OF LIFE; RESPIRATORY FAILURE; RIB FRACTURE; SIDE EFFECT; SUNLIGHT; THERMAL EXPOSURE; THORAX RADIOGRAPHY; VERTEBRA FRACTURE; VERTEBRA MALFORMATION; VITAMIN D DEFICIENCY; VITAMIN K DEFICIENCY; VITAMIN SUPPLEMENTATION; BONE; CONSENSUS DEVELOPMENT; PATHOPHYSIOLOGY; PHYSIOLOGY;

BONE AND BONES; BONE DISEASES; CYSTIC FIBROSIS; HUMANS; PRACTICE GUIDELINES;

EID: 20144389008     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1629     Document Type: Conference Paper

References (73)

1. Cystic Fibrosis Foundation 2003 Annual Report. 2002 Patient registry. Bethesda, MD: Cystic Fibrosis Foundation
2. Mischler EH, Chesney PJ, Chesney RW, Mazess RB 1979 Demineralization in cystic fibrosis detected by direct photon absorptiometry. Am J Dis Child 133:632-635
3. Hahn TJ, Squires AE, Halstead LR, Strominger DB 1979 Reduced serum 25-hydroxyvitamin D concentration and disordered mineral metabolism in patients with cystic fibrosis. J Pediatr 94:38-42
4. Elkin SL, Fairney A, Burnett S, Kemp M, Kyd P, Burgess J, Compston JE, Hodson ME 2001 Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a cross-sectional study. Osteoporos Int 12:366-372
5. Aris RM, Renner JB, Winders AD, Buell HE, Riggs DB, Lester GE, Ontjes DA 1998 Increased rate of fractures and severe kyphosis: sequelae of living to adulthood with cystic fibrosis. Ann Intern Med 128:186-193
6. Henderson RC, Madsen CD 1999 Bone mineral content and body composition in children and young adults with cystic fibrosis. Pediatr Pulmonol 27:80-84
7. Haworth CS, Selby PL, Webb AK, Dodd ME, Musson H, McL Niven R, Economou G, Horrocks AW, Freemont AJ, Mawer EB, Adams JE 1999 Low bone mineral density in adults with cystic fibrosis. Thorax 54:961-967
8. Moran CE, Sosa EG, Martinez SM, Geldern P, Messina D, Russo A, Boerr L, Bai JC 1997 Bone mineral density in patients with pancreatic insufficiency and steatorrhea. Am J Gastroenterol 92:867-871
9. Shane E, Silverberg SJ, Donovan D, Papadopoulos A, Staron RB, Addesso V, Jorgesen B, McGregor C, Schulman L 1996 Osteoporosis in lung transplantation candidates with end-stage pulmonary disease. Am J Med 101:262-269
10. Tschopp O, Boehler A, Speich R, Weder W, Seifert B, Russi EW, Schmid C 2002 Osteoporosis before lung transplantation: association with low body mass index, but not with underlying disease. Am J Transplant 2:167-172
11. Gibbens DT, Gilsanz V, Boechat MI, Dufer D, Carlson ME, Wang CI 1988 Osteoporosis in cystic fibrosis. J Pediatr 113:295-300
12. Conway SP, Morton AM, Oldroyd B, Truscott JG, White H, Smith AH, Haigh I 2000 Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax 55:798-804
13. Bachrach LK, Loutit CW, Moss RB 1994 Osteopenia in adults with cystic fibrosis. Am J Med 96:27-34
14. Grey AB, Ames RW, Matthews RD, Reid IR 1993 Bone mineral density and body composition in adult patients with cystic fibrosis. Thorax 48:589-593
15. Shaw N, Bedford C, Heaf D, Carty H, Dutton J 1995 Osteopenia in adults with cystic fibrosis. Am J Med 99:690-692
16. Rochat T, Slosman DO, Pichard C, Belli DC 1994 Body composition analysis by dual-energy x-ray absorptiometry in adults with cystic fibrosis. Chest 106:800-805
17. Henderson RC, Madsen CD 1996 Bone density in children and adolescents with cystic fibrosis. J Pediatr 128:28-34
18. Bhudhikanok GS, Lim J, Marcus R, Harkins A, Moss RB, Bachrach LK 1996 Correlates of osteopenia in patients with cystic fibrosis. Pediatrics 97:103-111
19. Bhudhikanok GS, Wang MC, Marcus R, Harkins A, Moss R, Bachrach LK 1998 Bone acquisition and loss in children and adults with cystic fibrosis: a longitudinal study. J Pediatr 133:18-27
20. Salamoni F, Roulet M, Gudinchet F, Pilet M, Thiebaud D, Burckhardt P 1996 Bone mineral content in cystic fibrosis patients: correlation with fat-free mass. Arch Dis Child 74:314-318
21. Hardin DS, Arumugam R, Seilheimer DK, LeBlanc A, Ellis KJ 2001 Normal bone mineral density in cystic fibrosis. Arch Dis Child 84:363-368
22. Humphries IR, Allen JR, Waters DL, Howman-Giles R, Gaskin KJ 1998 Volumetric bone mineral density in children with cystic fibrosis. Appl Radiat Isot 49:593-595
23. Laursen EM, Molgaard C, Michaelsen KF, Koch C, Muller J 1999 Bone mineral status in 134 patients with cystic fibrosis. Arch Dis Child 81:235-240
24. Sood M, Hambleton G, Super M, Fraser WD, Adams JE, Mughal MZ 2001 Bone status in cystic fibrosis. Arch Dis Child 84:516-520
25. Elkin SL, Vedi S, Bord S, Garrahan NJ, Hodson ME, Compston JE 2002 Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis. Am J Resp Crit Care Med 166:1470-1474
26. Haworth CS, Webb AK, Egan JJ, Selby PL, Hasleton PS, Bishop PW, Freemont TJ 2000 Bone histomorphometry in adult patients with cystic fibrosis. Chest 118:434-439
27. Bachrach LK 2001 Acquisition of optimal bone mass in childhood and adolescence. Trends Endocrinol Metab 12:22-27
28. Bailey DA, McKay HA, Mirwald RL, Crocker PR, Faulkner RA 1999 A six-year longitudinal study of the relationship of physical activity to bone mineral accrual in growing children; The University of Saskatchewan Bone Mineral Accrual Study. J Bone Miner Res 14:1672-1679
29. Mortensen LA, Chan GM, Alder SC, Marshall BC 2000 Bone mineral status in prepubertal children with cystic fibrosis. J Pediatr 136:648-652
30. Buntain HM, Greer RM, Schluter PJ, Wong JC, Batch JA, Potter JM, Lewindon PJ, Powell E, Wainwright CE, Bell SC 2004 Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax 59:149-155
31. Haworth CS, Selby PL, Horrocks AW, Mawer EB, Adams JE, Webb AK 2002 A prospective study of change in bone mineral density over one year in adults with cystic fibrosis. Thorax 57:719-723
32. Aris RM, Lester GE, Camaniti M, Hensler M, Lark RK, Blackwood AD, Brown SA, Renner JB, Neuringer IP, Chalermskulrat W, Ontjes DA 2004 Alendronate for cystic fibrosis adults with low bone density: results of a randomized, controlled trial. Am J Respir Crit Care Med 169:77-82
33. Baroncelli GI, De Luca F, Magazzu G, Arrigo T, Sferlazzas C, Catena C, Bertelloni S, Saggese G 1997 Bone demineralization in cystic fibrosis: evidence of imbalance between bone formation and degradation. Pediatr Res 41:397-403
34. Aris RM, Ontjes DA, Buell HE, Blackwood AD, Lark RK, Brown SA, Caminiti M, Chalermskulrat W, Renner JB, Lester GE 2002 Abnormal bone turnover in cystic fibrosis adults. Osteoporos Int 13:151-157
35. De Schepper J, Smitz J, Dab I, Piepsz A, Jonckheer M, Bergmann P 1993 Low serum bone γ-carboxyglutamic acid protein concentrations in patients with cystic fibrosis: correlation with hormonal parameters and bone mineral density. Horm Res 39:197-201
36. Schulze KJ, O'Brien KO, Germain-Lee EL, Booth SL, Leonard A, Rosenstein BJ 2004 Calcium kinetics are altered in clinically stable girls with cystic fibrosis. J Clin Endocrinol Metab 89:3385-3391
37. Borowitz D, Baker RD, Stallings V 2002 Consensus report on nutrition for pediatric patients with cystic fibrosis. J Pediatr Gastroenterol Nutr 35:246-259
38. Ott SM, Aitken ML 1998 Osteoporosis in patients with cystic fibrosis. Clin Chest Med 19:555-567
39. Donovan Jr DS, Papadopoulos A, Staron RB, Addesso V, Schulman L, McGregor C, Cosman F, Lindsay RL, Shane E 1998 Bone mass and vitamin D deficiency in adults with advanced cystic fibrosis lung disease. Am J Respir Crit Care Med 157:1892-1899
40. Lark RK, Lester GE, Ontjes DA, Blackwood AD, Hollis BW, Hensler MM, Aris RM 2001 Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. Am J Clin Nutr 73:602-606
41. Wilson DC, Rashid M, Durie PR, Tsang A, Kalnins D, Andrew M, Corey M, Shin J, Tullis E, Pencharz PB 2001 Treatment of vitamin K deficiency in cystic fibrosis: effectiveness of a daily fat-soluble vitamin combination. J Pediatr 138:851-855
42. Aris RM, Brown SA, Ontjes DA, Chalermskulrat W, Neuringer IP, Lester GE 2003 Reduced carboxylated osteocalcin levels in cystic fibrosis. Am J Respir Crit Care Med 168:1129
43. Levin ME, VC Boisseau, LV Avioli 1976 Effects of diabetes mellitus on bone mass in juvenile and adult-onset diabetes. N Engl J Med 294:241-245
44. Stead RJ, Hodson ME, Batten JC, Adams J, Jacobs HS 1987 Amenorrhoea in cystic fibrosis. Clin Endocrinol (Oxf) 26:187-195
45. Landon C, Rosenfeld RG 1984 Short stature and pubertal delay in male adolescents with cystic fibrosis. Androgen treatment. Am J Dis Child 138:388-391
46. Moshang T, Holsclaw Jr DS 1980 Menarchal determinants in cystic fibrosis. Am J Dis Child 134:1139-1142
47. Johannesson M, Landgren BM, Csemiczky G, Hjelte L, Gottlieb C 1998 Female patients with cystic fibrosis suffer from reproductive endocrinological disorders despite good clinical status. Hum Reprod 13:2092-2097
48. Weltman EA, Stern RC, Doershuk CF, Moir RN, Palmer K, Jaffe AC 1990 Weight and menstrual function in patients with eating disorders and cystic fibrosis. Pediatrics 85:282-287
49. Boas SR, Cleary DA, Lee PA, Orenstein DM 1996 Salivary testosterone levels in male adolescents with cystic fibrosis. Pediatrics 97:361-363
50. Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311
51. Aris RM, Stevens A, Ontjes DA, Blackwood AD, Lark RK, Hensler M, Neuringer IP, Lester GE 2000 Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. Am J Respir Crit Care Med 162:1674-1678
52. Konstan MW, Butler SM, Schidlow DV, Morgan WJ, Julius JR, Johnson CA 1999 Patterns of medical practice in cystic fibrosis. II. Use of therapies. Investigators and coordinators of the epidemiologic study of cystic fibrosis. Pediatr Pulmonol 28:248-254
53. Ferrari SL, Nicod LP, Harnacher J, Spiliopoulos A, Slosman DO, Rochat T, Bonjour JP, Rizzoli R 1996 Osteoporosis in patients undergoing lung transplantation. Eur Respir J 9:2378-2382
54. Spira A, Gutierrez C, Chaparro C, Hutcheon MA, Chan CK 2000 Osteoporosis and lung transplantation: a prospective study. Chest 117:476-481
55. Aris RM, Neuringer IP, Egan TM, Weiner M, Ontjes D 1996 Severe osteoporosis before and after lung transplantation. Chest 109:1176-1183
56. Rodino MA, Shane E 1998 Osteoporosis after organ transplantation. Am J Med 104:459-469
57. Aris RM, Lester GE, Renner JB, Winders AW, Blackwood AD, Lark RK, Ontjes DA 2000 Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. Am J Respir Crit Care Med. 162:941-946
58. Aringer M, Kiener HP, Koeller MD, Artemiou O, Zuckermann A, Wieselthaler G, Klepetko W, Seidl G, Kainberger F, Bernecker P, Smolen JS, Pietschmann P 1998 High turnover bone disease following lung transplantation. Bone 23:485-488
59. Shane E, Papadopoulos A, Staron RB, Addesso V, Donovan D, McGregor C, Schulman LL 1999 Bone loss and fracture after lung transplantation. Transplantation 68:220-227
60. Henderson RC, Specter BB 1994 Kyphosis and fractures in children and young adults with cystic fibrosis. J Pediatr 125:208-212
61. Erkkila J, Warwick W, Bradford D 1978 Spine deformities and cystic fibrosis. Clin Orthop 131:146-149
62. Denton J, Tietjen R, Gaerlan P 1979 Thoracic kyphosis in cystic fibrosis. Clin Orthop 155:71-74
63. Logvinoff M, Fon G, Taussig LM, Pitt MJ 1984 Kyphosis and pulmonary function cystic fibrosis. Clin Pediatr 23:389-392
64. Hanly JG, McKenna MJ, Quigley C, Freaney R, Muldowney FP, FitzGerald MX 1985 Hypovitaminosis D and response to supplementation in older patients with cystic fibrosis. Q J Med 56:377-385
65. Kelly E, Marsh R, Pencharz P, Tullis E 2002 Effect of vitamin D supplementation on low serum 25-hydroxyvitamin D in adults with cystic fibrosis [Abstract]. Pediatr Pulmonol 24(Suppl):344
66. Boyle MP, Noschese ML, Watts SL, Davis ME, Lechtzin N 2003 Prevalence of 25-hydroxyvitamin D deficiency in adults with CF and effect of high dose ergocalciferol supplementation [Abstract]. Ped Pulmonol 25(Suppl):350
67. Enfissi L, Bianchi ML, Galbiati E, Faraifoger S, Arban, Moretti E, Giunta A 2001 Osteoporosis in CF: calcifediol therapy increases bone mineral density (BMD). Pediatr Pulmonol Suppl 22:334 (Abstract 475)
68. Brown S, Ontjes D, Lark R, Blackwood A, Hensler M, Caminiti M, Aris R 2003 Short-term calcitriol administration improves calcium homeostasis in adults with CF. Osteoporos Int 14:442-449
69. Ontjes DA, Lark RK, Lester GE, Aris RM 2000 Vitamin D depletion and replacement in patients with cystic fibrosis. In: Norman A, Bouillon R, eds. Vitamin D endocrine system: structural, biological, genetic and clinical aspects. Riverside, CA: Thomasset, University of California; 893-896
70. Haworth CS, Selby PL, Adams JE, Mawer EB, Horrocks AW, Webb AK 2001 Effect of intravenous pamidronate on bone mineral density in adults with cystic fibrosis. Thorax 56:314-316
71. Haworth CS, Selby PL, Webb AK, Mawer EB, Adams JE, Freemont TJ 1998 Severe bone pain after intravenous pamidronate in adult patients with cystic fibrosis. Lancet 352:1753-1754
72. Hardin DS, Ellis KJ, Dyson M, Rice J, McConnell R, Seilheimer DK 2001 Growth hormone decreases protein catabolism in children with cystic fibrosis. J Clin Endocrinol Metab 86:4424-4428
73. Hardin DS, Ellis KJ, Dyson M, Rice J, McConnell R, Seilheimer DK 2001 Growth hormone improves clinical status in prepubertal children with cystic fibrosis: results of a randomized controlled trial. J Pediatr 139:636-642