Investigation of the potential pharmacokinetic and pharmacodynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis

Biopharmaceutics and Drug Disposition

Volumn 27, Issue 5, 2006, Pages 229-240

  Raje, Sangeeta ^a   Cornish, Jennifer ^a   Newman, Amy H ^b   Cao, Jianjing ^b   Katz, Jonathan L ^b   Eddington, Natalie D ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Benztropine analogs; Cocaine; Dopamine transporter; Drug interaction; Pharmacokinetics pharmacodynamics

Indexed keywords

3ALPHA [BIS(4' FLUOROPHENYL)METHOXY]TROPANE; AHN 1 055; BENZATROPINE; COCAINE; DOPAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BRAIN; COCAINE DEPENDENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DEPENDENCE TREATMENT; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SUBSTITUTION; EXTRACELLULAR FLUID; IC 50; MALE; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; PARTITION COEFFICIENT; PHARMACODYNAMICS; PHARMACOLOGICAL PARAMETERS; RAT; STATISTICAL SIGNIFICANCE; STEREOTAXIS;

ANIMALS; BENZTROPINE; BRAIN; BRAIN CHEMISTRY; COCAINE; COCAINE-RELATED DISORDERS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DRUG INTERACTIONS; INHIBITORY CONCENTRATION 50; MALE; MICRODIALYSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33746467424     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.497     Document Type: Article

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