Loss of heterozygosity analysis in ductal lavage samples from BRCA1 AND BRCA2 carriers: A cautionary tale

Cancer Epidemiology Biomarkers and Prevention

Volumn 15, Issue 7, 2006, Pages 1396-1398

  Antill, Yoland C ^a,b   Mitchell, Gillian ^a   Johnson, Sandra A ^a   Devereux, Lisa ^a   Milner, Alvin ^a   Phillips, Kelly Anne ^a,b   Campbell, Ian G ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; TUMOR MARKER;

ADULT; ALLELE; ARTICLE; BREAST CANCER; BREAST DUCT; CONTROLLED STUDY; DNA DETERMINATION; DNA EXTRACTION; FEMALE; HETEROZYGOSITY LOSS; HETEROZYGOTE; HUMAN; HUMAN EXPERIMENT; LAVAGE; MICROSATELLITE MARKER; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; BODY FLUIDS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; DNA, NEOPLASM; FEMALE; GENES, BRCA1; GENES, BRCA2; GERM-LINE MUTATION; HETEROZYGOTE; HUMANS; IRRIGATION; LOSS OF HETEROZYGOSITY; MIDDLE AGED;

EID: 33746421847     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-05-0986     Document Type: Article

References (15)

1. Antoniou A, Pharoah PD, Narod S, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 2003;72:1117-30.
2. Ford D, Easton DF, Stratton M, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet 1998;62:676-89.
3. Brekelmans CT, Seynaeve C, Bartels CC, et al. Effectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high familial risk. J Clin Oncol 2001;19:924-30.
4. Dooley WC, Ljung BM, Veronesi U, et al. Ductal lavage for detection of cellular atypia in women at high risk for breast cancer. J Natl Cancer Inst 2001;93:1624-32.
5. King BL, Crisi GM, Tsai SC, Haffty BG, Phillips RF, Rimm DL. Immunocytochemical analysis of breast cells obtained by ductal lavage. Cancer 2002;96:244-9.
6. Osorio A, de la Hoya M, Rodriguez-Lopez R, et al. Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer. Int J Cancer 2002;99:305-9.
7. Esteller M, Silva JM, Dominguez G, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian rumors. J Natl Cancer Inst 2000;92:564-9.
8. Isaacs C, Cavalli LR, Cohen Y, et al. Detection of LOH, mitochondrial DNA. alterations in ductal lavage and nipple aspirate fluids from high-risk patients. Breast Cancer Res Treat 2004;84:99-105.
9. Yonekura Y, Yamamoto D, Okugawa H, Tanaka K, Kamiyama Y. Loss of heterozygosity in ductal lavage for breast tumor and the contralateral breast. Oncol Rep 2005;13:739-43.
10. Tomlinson IP, Lambros MB, Roylance RR. Loss of heterozygosity analysis: practically and conceptually flawed? Genes Chromosomes Cancer 2002;34:349-53.
11. Mitchell G, Antill YC, Murray W, et al. Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation. Breast Cancer Res 2005;7:R1122-31.
12. Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004;64:7678-81.
13. Evron E, Dooley WC, Umbricht CB, et al. Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR. Lancet 2001;357:1335-6.
14. Fackler MJ, McVeigh M, Mehrotra J, et al. Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer. Cancer Res 2004;64:4442-52.
15. Krassenstein R, Sauter E, Dulaimi E, et al. Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation. Clin Cancer Res 2004;10:28-32.