Vardenafil 20-mg demonstrated superior efficacy to 10-mg in Japanese men with diabetes mellitus suffering from erectile dysfunction

International Journal of Urology

Volumn 13, Issue 8, 2006, Pages 1066-1072

  Ishii, Nobuhisa ^a   Nagao, Koichi ^a   Fujikawa, Keita ^c   Tachibana, Takashi ^c   Iwamoto, Yasuhiko ^b   Kamidono, Sadao ^d  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c BAYER YAKUHIN LTD   (Japan)

^d KOBE UNIVERSITY   (Japan)

Author keywords

Diabetes; Erectile dysfunction; Phosphodiesterase inhibitors; Vardenafil

Indexed keywords

CREATINE KINASE; VARDENAFIL;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DIABETES MELLITUS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ERECTILE DYSFUNCTION; FOLLOW UP; HEADACHE; HEART PALPITATION; HOT FLUSH; HUMAN; MALE; MULTICENTER STUDY; NOSE CONGESTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SCREENING; UPPER RESPIRATORY TRACT INFECTION;

ADULT; DIABETES COMPLICATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ERECTILE DYSFUNCTION; HUMANS; IMIDAZOLES; IMPOTENCE; JAPAN; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; SULFONES; TREATMENT OUTCOME; TRIAZINES;

EID: 33746415303     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2006.01480.x     Document Type: Article

References (16)

1. NIH Consensus Development Panel on Impotence. NIH Consensus Conference: impotence. JAMA 1993; 270: 83-90.
2. Vinik A, Richardson D. Erectile dysfunction in diabetes. Diabetes Rev. 1998; 6: 16-33.
3. Fedele D, Coscelli C, Santeusanio F et al. Erectile dysfunction in diabetic subjects in Italy. Diabetes Care 1998; 21: 1973-77.
4. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999; 281: 537-44.
5. De Berardis G, Franciosi M, Belfiglio M et al. Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked. Diabetes Care 2002; 25: 284-91.
6. Shabsigh R, Klein LT, Seidman S, Kaplan SA, Lehrhoff BJ, Ritter JS. Increased incidence of depressive symptoms in men with erectile dysfunction. Urology 1998; 52: 848-52.
7. Azadzoi KM, Saenz de Tejada I. Diabetes mellitus impairs neurogenic and endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. J. Urol. 1992; 148: 1587-91.
8. Ayan S, Yildirim S, Ucar C, Sarioglu Y, Gultekin Y, Butuner C. Corporal reactivity to adenosine and prostaglandin E1 in alloxan-induced diabetic rabbit corpus cavernosum, and the effect of insulin therapy. BJU Int. 1999; 83: 108-12.
9. Saenz de Tejada I, Angulo J, Cuevas P et al. The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int. J. Impot. Res. 2001; 13: 282-90.
10. Bischoff E, Schneider K. A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection. Int. J. Impot. Res. 2001; 13: 230-5.
11. Kim NN, Huang YH, Goldstein I, Bischoff E, Traish AM. Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor. Life Sci. 2001; 69: 2249-56.
12. Goldstein I, Young JM, Fischer J, Bangerter K, Segerson T, Taylor T. Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care 2003; 26: 777-83.
13. Shirai M. Randomized placebo-controlled double-blind study of oral sildenafil in Japanese men with erectile dysfunction. Nishinihon J. Urol. 2000; 62: 373.
14. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822-30.
15. Nagao K, Ishii N, Kamidono S, Osada T. Safety and Efficacy of Vardenafil (BAY38-9456) in Patients with Erectile Dysfunction: a Phase IIb Study in Japan. Int. J. Urol. 2004; 11: 515-24.
16. Hatzichristou DG. Sildenafil citrate: lessons learned from 3 years of clinical experience. Int. J. Impot. Res. 2002; 14: S43-S52.