A splice variant to PACAP receptor that is involved in spermatogenesis is expressed in astrocytes

Annals of the New York Academy of Sciences

Volumn 1070, Issue , 2006, Pages 484-490

  Pilzer, Inbar ^a   Gozes, Illana ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Astrocytes; PAC1; PACAP; Splice variants; VIP

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR PAC 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ASTROCYTE; CONFERENCE PAPER; NEWBORN; NONHUMAN; PROTEIN VARIANT; RAT; SPERMATOGENESIS; TESTIS;

EID: 33746405107     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1317.067     Document Type: Conference Paper

References (18)

1. PISEGNA, J.R. & S.A. WANK. 1996. Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C. J. Biol. Chem. 271:
2. SHIVERS, B.D. et al. 1991. Two high affinity binding sites for pituitary adenylate cyclase-activating polypeptide have different tissue distributions. Endocrinology 128: 3055-3065.
3. HARMAR, A. J. et al. 1998. International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol. Rev. 50: 265-270.
4. JOURNOT, L. et al. 1995. Differential signal transduction by six splice variants of the pituitary adenylate cyclase-activating peptide (PACAP) receptor. Biochem. Soc. Trans. 23: 133-137.
5. SPENGLER, D. et al. 1993. Differential signal transduction by five splice variants of the PACAP receptor. Nature 365: 170-175.
6. ASHUR-FABIAN, O. et al. 1997. Identification of VTP/PACAP receptors on rat astrocytes using antisense oligodeoxynucleotides. J. Mol. Neurosci. 9: 211-222.
7. CHATTERJEE, T.K., R.V. SHARMA & R.A. FISHER. 1996. Molecular cloning of a novel variant of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor that stimulates calcium influx by activation of L-type calcium channels. J. Biol. Chem. 271: 32226-32232.
8. ALEXANDRE, D. et al. 2002. Novel splice variants of type I pituitary adenylate cyclase-activating polypeptide receptor in frog exhibit altered adenylate cyclase stimulation and differential relative abundance. Endocrinology 143: 2680-2692.
9. PANTALONI, C. et al. 1996. Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation. J. Biol. Chem. 271: 22146-22151.
10. DAUTZENBERG, F.M. et al. 1999. N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. J. Neuroendocrinol. 11: 941-949.
11. DANIEL, P.B. et al. 2001. Novel alternatively spliced exon in the extracellular ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) selectively increases ligand affinity and alters signal transduction coupling during spermatogenesis. J. Biol. Chem. 276: 12938-12944.
12. DEUTSCH, P.J., V.C. SCHADLOW & N. BARZILAI. 1993. 38-Amino acid form of pituitary adenylate cyclase activating peptide induces process outgrowth in human neuroblastoma cells. J. Neurosci. Res. 35: 312-320.
13. MAY, V. & K.M. BRAAS. 1995. Pituitary adenylate cyclase-activating polypeptide (PACAP) regulation of sympathetic neuron neuropeptide Y and catecholamine expression. J. Neurochem. 65: 978-987.
14. ZUSEV, M. & I. GOZES. 2004. Differential regulation of activity-dependent neuro-protective protein in rat astrocytes by VIP and PACAP. Regul. Pept. 123: 33-41.
15. LU, N. & E. DICICCO-BLOOM. 1997. Pituitary adenylate cyclase-activating polypeptide is an autocrine inhibitor of mitosis in cultured cortical precursor cells. Proc. Natl. Acad. Sci. USA 94: 3357-3362.
16. ARIMURA, A. et al. 1994. PACAP functions as a neurotrophic factor. Ann. N. Y. Acad. Sci. 739: 228-243.
17. REGLODI, D. et al. 2002. Effects of pretreatment with PACAP on the infarct size and functional outcome in rat permanent focal cerebral ischemia. Peptides 23: 2227-2234.
18. CHEN, W.H. & S.F. TZENG. 2005. Pituitary adenylate cyclase-activating polypeptide prevents cell death in the spinal cord with traumatic injury. Neurosci. Lett. 384: 117-121.