Slow transit colon constipation is not related to the number of interstitial cells of Cajal

International Journal of Colorectal Disease

Volumn 21, Issue 6, 2006, Pages 527-532

  Toman, Jeffrey ^a   Turina, Matthias ^a   Ray, Mukunda ^a   Petras, Robert E ^b   Stromberg, Arnold J ^c   Galandiuk, Susan ^a  

^a University of Louisville School of Medicine   (United States)

^b Ameripath Institute of Gastrointestinal Pathology and Digestive Disease   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Colonic pseudoobstruction; Constipation; Interstitial cells of Cajal; Intestinal obstruction

Indexed keywords

BISACODYL; CD34 ANTIGEN; LAXATIVE; MACROGOL; MAGNESIUM CITRATE; MAGNESIUM HYDROXIDE; POLYVINYLCHLORIDE; STEM CELL FACTOR RECEPTOR;

ADULT; ARTICLE; CELL COUNT; CHRONIC DISEASE; CLINICAL ARTICLE; COLON; COLON RESECTION; CONSTIPATION; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; HUMAN; HUMAN TISSUE; IMAGING SYSTEM; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; INTERSTITIAL CELL OF CAJAL; INTESTINE INNERVATION; INTESTINE MUSCLE; INTESTINE TRANSIT TIME; INTESTINE WALL; MYENTERIC PLEXUS; NERVE CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; THICKNESS;

ADULT; AGED; AGED, 80 AND OVER; CELL COUNT; COILED BODIES; COLECTOMY; COLON; CONSTIPATION; DIAGNOSIS, DIFFERENTIAL; GASTROINTESTINAL TRANSIT; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 33746346742     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-005-0041-1     Document Type: Article

References (15)

1. Jain D, Moussa K, Tandon M et al (2003) Role of interstitial cells of Cajal in motility disorders of the bowel. Am J Gastroenterol 98:618-624
2. Daniel EE (2001) Physiology and pathophysiology of the interstitial cell of Cajal: From bench to bedside. III. Interaction of interstitial cells of Cajal with neuromediators: An interim assessment. Am J Physiol Gastrointest Liver Physiol 281:G1329-G1332
3. Lyford GL, He CL, Soffer E et al (2002) Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation. Gut 51:496-501
4. Sabri M, Barksdale E, Di Lorenzo C (2003) Constipation and lack of colonic interstitial cells of Cajal. Dig Dis Sci 48:849-853
5. Streutker CJ, Huizinga JD, Campbell F et al (2003) Loss of CD117 (c-kit)- and CD34-positive ICC and associated CD34-positive fibroblasts defines a subpopulation of chronic intestinal pseudo-obstruction. Am J Surg Pathol 27:228-235
6. Tong WD, Liu BH, Zhang LY et al (2004) Decreased interstitial cells of Cajal in the sigmoid colon of patients with slow transit constipation. Int J Colorectal Dis 19:467-473
7. Wedel T, Spiegler J, Soellner S et al (2002) Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon. Gastroenterology 123:1459-1467
8. Vanderwinden JM, Rumessen JJ, De Laet MH et al (1999) CD34+ cells in human intestine are fibroblasts adjacent to, but distinct from, interstitial cells of Cajal. Lab Invest 79:59-65
9. Wang S, Saboorian MH, Frenkel EP et al (2001) Assessment of HER-2/neu status in breast cancer: Automated Cellular Imaging System (ACIS)-assisted quantitation of immunohistochemical assay achieves high accuracy in comparison with fluorescence in situ hybridization assay as the standard. Am J Clin Pathol 116:495-503
10. Vanderwinden JM, Rumessen JJ, De Laet MH et al (2000) CD34 immunoreactivity and interstitial cells of Cajal in the human and mouse gastrointestinal tract. Cell Tissue Res 302:145-153
11. Kindblom LG, Remotti HE, Aldenborg F et al (1998) Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 152:1259-1269
12. Hirota S, Isozaki K, Moriyama Y et al (1998) Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279:577-580
13. Sircar K, Hewlett BR, Huizinga JD et al (1999) Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol 23:377-389
14. Song G, David G, Hirst S et al (2005) Regional variation in ICC distribution, pacemaking activity and neural responses in the longitudinal muscle of the murine stomach. J Physiol 564:523-540
15. Hirst S, Dickens EJ, Edwards FR (2002) Pacemaker shift in the gastric antrum of guinea-pigs produced by excitatory vagal stimulation involves intramuscular interstitial cells. J Physiol 541:917-928