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Volumn 11, Issue 3, 2006, Pages 117-123

Ursodeoxycholic acid in primary biliary cirrhosis improves glutathione status but fails to reduce lipid peroxidation

Author keywords

glutamyl transferase; Glutathione; Lipid peroxidation; Oxidant stress; Primary biliary cirrhosis; Ursodeoxycholic acid

Indexed keywords

8 ISOPROSTANE; ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIPID; MALONALDEHYDE; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; RETINOL; SELENIUM; THIOBARBITURIC ACID REACTIVE SUBSTANCE; URATE; URSODEOXYCHOLIC ACID;

EID: 33746342804     PISSN: 13510002     EISSN: 13510002     Source Type: Journal    
DOI: 10.1179/135100006X116600     Document Type: Article
Times cited : (12)

References (39)
  • 1
    • 0025876404 scopus 로고
    • A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis
    • Poupon RE, Balkau B, Eschwege E, Poupon R. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N Engl J Med 1991; 324: 1548-1554
    • (1991) N Engl J Med , vol.324 , pp. 1548-1554
    • Poupon, R.E.1    Balkau, B.2    Eschwege, E.3    Poupon, R.4
  • 2
    • 0033604026 scopus 로고    scopus 로고
    • Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: A meta-analysis
    • Goulis J, Leandro G, Burroughs AK. Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: a meta-analysis. Lancet 1999; 354: 1053-1060.
    • (1999) Lancet , vol.354 , pp. 1053-1060
    • Goulis, J.1    Leandro, G.2    Burroughs, A.K.3
  • 3
    • 14944361288 scopus 로고    scopus 로고
    • The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis
    • Corpechot C, Carrat F, Bahr A, Chretien Y, Poupon RE, Poupon R. The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 2005; 128: 297-303.
    • (2005) Gastroenterology , vol.128 , pp. 297-303
    • Corpechot, C.1    Carrat, F.2    Bahr, A.3    Chretien, Y.4    Poupon, R.E.5    Poupon, R.6
  • 4
    • 0025247125 scopus 로고
    • Hepatic injury induced by bile salts: Correlation between biochemical and morphological events
    • Schmucker DL, Ohta M, Kanai S, Sato Y, Kitani K. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology 1990; 12: 1216-1221.
    • (1990) Hepatology , vol.12 , pp. 1216-1221
    • Schmucker, D.L.1    Ohta, M.2    Kanai, S.3    Sato, Y.4    Kitani, K.5
  • 5
    • 0033172845 scopus 로고    scopus 로고
    • Mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases
    • Trauner M, Graziadei IW. Mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases. Aliment Pharmacol Ther 1999; 13: 979-996.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 979-996
    • Trauner, M.1    Graziadei, I.W.2
  • 6
    • 0034945397 scopus 로고    scopus 로고
    • Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'
    • Lazaridis KN, Gores GJ, Lindor KD. Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'. J Hepatol 2001; 35: 134-146.
    • (2001) J Hepatol , vol.35 , pp. 134-146
    • Lazaridis, K.N.1    Gores, G.J.2    Lindor, K.D.3
  • 7
    • 0025202952 scopus 로고
    • Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man
    • Marteau P, Chazouilleres O, Myara A, Jian R, Rambaud JC, Poupon R. Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man. Hepatology 1990; 12: 1206-1208.
    • (1990) Hepatology , vol.12 , pp. 1206-1208
    • Marteau, P.1    Chazouilleres, O.2    Myara, A.3    Jian, R.4    Rambaud, J.C.5    Poupon, R.6
  • 8
    • 0033985520 scopus 로고    scopus 로고
    • Mitochondrial membrane perturbations in cholestasis
    • Rodrigues CM, Steer CJ. Mitochondrial membrane perturbations in cholestasis. J Hepatol 2000; 32: 135-141.
    • (2000) J Hepatol , vol.32 , pp. 135-141
    • Rodrigues, C.M.1    Steer, C.J.2
  • 9
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid
    • Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990; 11: 12-15.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 10
    • 0035069055 scopus 로고    scopus 로고
    • Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids
    • Sokol RJ, Straka MS, Dahl R et al. Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids. Pediatr Res 2001; 49: 519-531.
    • (2001) Pediatr Res , vol.49 , pp. 519-531
    • Sokol, R.J.1    Straka, M.S.2    Dahl, R.3
  • 11
    • 0035129976 scopus 로고    scopus 로고
    • Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition
    • Yerushalmi B, Dahl R, Devereaux MW, Gumpricht E, Sokol RJ. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology 2001; 33: 616-626.
    • (2001) Hepatology , vol.33 , pp. 616-626
    • Yerushalmi, B.1    Dahl, R.2    Devereaux, M.W.3    Gumpricht, E.4    Sokol, R.J.5
  • 12
    • 0029825946 scopus 로고    scopus 로고
    • Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages
    • Ljubuncic P, Fuhrman B, Oiknine J, Aviram M, Bomzon A. Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages. Gut 1996; 39: 475-478.
    • (1996) Gut , vol.39 , pp. 475-478
    • Ljubuncic, P.1    Fuhrman, B.2    Oiknine, J.3    Aviram, M.4    Bomzon, A.5
  • 13
    • 0032124868 scopus 로고    scopus 로고
    • Effect of bile acids on lipid peroxidation: The role of iron
    • Sreejayan N, von Ritter C. Effect of bile acids on lipid peroxidation: the role of iron. Free Radic Biol Med 1998; 25: 50-56.
    • (1998) Free Radic Biol Med , vol.25 , pp. 50-56
    • Sreejayan, N.1    von Ritter, C.2
  • 14
    • 0036890346 scopus 로고    scopus 로고
    • Antioxidant properties of ursodeoxycholic acid
    • Lapenna D, Ciofani G, Festi D et al. Antioxidant properties of ursodeoxycholic acid. Biochem Pharmacol 2002; 64: 1661-1667.
    • (2002) Biochem Pharmacol , vol.64 , pp. 1661-1667
    • Lapenna, D.1    Ciofani, G.2    Festi, D.3
  • 15
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001; 35: 297-306.
    • (2001) J Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 16
    • 0036623357 scopus 로고    scopus 로고
    • Oxidative stress in chronic hepatitis C: Not just a feature of late stage disease
    • Jain SK, Pemberton PW, Smith A et al. Oxidative stress in chronic hepatitis C: not just a feature of late stage disease. J Hepatol 2002; 36: 805-811.
    • (2002) J Hepatol , vol.36 , pp. 805-811
    • Jain, S.K.1    Pemberton, P.W.2    Smith, A.3
  • 18
    • 24744456677 scopus 로고    scopus 로고
    • Non-invasive monitoring of oxidant stress in alcoholic liver disease
    • Pemberton PW, Smith A, Warnes TW. Non-invasive monitoring of oxidant stress in alcoholic liver disease. Scand J Gastroenterol 2005; 40: 1102-1108.
    • (2005) Scand J Gastroenterol , vol.40 , pp. 1102-1108
    • Pemberton, P.W.1    Smith, A.2    Warnes, T.W.3
  • 19
    • 0037456669 scopus 로고    scopus 로고
    • Oxidant stress is a significant feature of primary biliary cirrhosis
    • Aboutwerat A, Pemberton PW, Smith A et al. Oxidant stress is a significant feature of primary biliary cirrhosis. Biochim Biophys Acta 2003; 1637: 142-150.
    • (2003) Biochim Biophys Acta , vol.1637 , pp. 142-150
    • Aboutwerat, A.1    Pemberton, P.W.2    Smith, A.3
  • 21
    • 0018380993 scopus 로고
    • Serum bilirubin: A prognostic factor in primary biliary cirrhosis
    • Shapiro JM, Smith H, Schaffner F. Serum bilirubin: a prognostic factor in primary biliary cirrhosis. Gut 1979; 20: 137-140.
    • (1979) Gut , vol.20 , pp. 137-140
    • Shapiro, J.M.1    Smith, H.2    Schaffner, F.3
  • 23
    • 0026701545 scopus 로고
    • Enhanced chemiluminescent assay for antioxidant capacity in biological fluids
    • Whitehead TP, Thorpe GH, Maxwell SR. Enhanced chemiluminescent assay for antioxidant capacity in biological fluids. Anal Chim Acta 1992; 266: 265-277.
    • (1992) Anal Chim Acta , vol.266 , pp. 265-277
    • Whitehead, T.P.1    Thorpe, G.H.2    Maxwell, S.R.3
  • 24
    • 0021288857 scopus 로고
    • Glutathione disulfide (GSSG) efflux from cells and tissues
    • Sies H, Akerboom TP. Glutathione disulfide (GSSG) efflux from cells and tissues. Methods Enzymol 1984; 105: 445-451.
    • (1984) Methods Enzymol , vol.105 , pp. 445-451
    • Sies, H.1    Akerboom, T.P.2
  • 25
    • 0023939979 scopus 로고
    • Type III procollagen peptide: A marker of disease activity and prognosis in primary biliary cirrhosis
    • Babbs C, Smith A, Hunt LP, Rowan BP, Haboubi NY, Warnes TW. Type III procollagen peptide: a marker of disease activity and prognosis in primary biliary cirrhosis. Lancet 1988; 1: 1021-1024.
    • (1988) Lancet , vol.1 , pp. 1021-1024
    • Babbs, C.1    Smith, A.2    Hunt, L.P.3    Rowan, B.P.4    Haboubi, N.Y.5    Warnes, T.W.6
  • 26
    • 12144286014 scopus 로고    scopus 로고
    • Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress
    • Serviddio G, Pereda J, Pallardo FV et al. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology 2004; 39: 711-720.
    • (2004) Hepatology , vol.39 , pp. 711-720
    • Serviddio, G.1    Pereda, J.2    Pallardo, F.V.3
  • 27
    • 0344867846 scopus 로고    scopus 로고
    • S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multicenter clinical trial
    • Mato JM, Camara J, Fernandez de Paz J et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999; 30: 1081-1089.
    • (1999) J Hepatol , vol.30 , pp. 1081-1089
    • Mato, J.M.1    Camara, J.2    Fernandez de Paz, J.3
  • 28
    • 0019740345 scopus 로고
    • Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples
    • Akerboom TP, Sies H. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol 1981; 77: 373-382.
    • (1981) Methods Enzymol , vol.77 , pp. 373-382
    • Akerboom, T.P.1    Sies, H.2
  • 29
    • 0033067354 scopus 로고    scopus 로고
    • Regulation of hepatic glutathione synthesis: Current concepts and controversies
    • Lu SC. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J 1999; 13: 1169-1183.
    • (1999) FASEB J , vol.13 , pp. 1169-1183
    • Lu, S.C.1
  • 30
    • 0036109728 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid on methionine adenyltransferase activity and hepatic glutathione metabolism in rats
    • Rodriguez-Ortigosa CM, Cincu RN, Sanz S, Ruiz F, Quiroga J, Prieto J. Effect of ursodeoxycholic acid on methionine adenyltransferase activity and hepatic glutathione metabolism in rats. Gut 2002; 50: 701-7060
    • (2002) Gut , vol.50 , pp. 701-7060
    • Rodriguez-Ortigosa, C.M.1    Cincu, R.N.2    Sanz, S.3    Ruiz, F.4    Quiroga, J.5    Prieto, J.6
  • 31
    • 0033600824 scopus 로고    scopus 로고
    • Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants
    • Mitsuyoshi H, Nakashima T, Sumida Y et al. Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants. Biochem Biophys Res Commun 1999; 263: 537-542.
    • (1999) Biochem Biophys Res Commun , vol.263 , pp. 537-542
    • Mitsuyoshi, H.1    Nakashima, T.2    Sumida, Y.3
  • 32
    • 0021165717 scopus 로고
    • Mechanism of biliary secretion of membranous enzymes: Bile acids are important factors for biliary occurrence of gamma-glutamyltransferase and other hydrolases
    • Hirata E, Inoue M, Morino Y. Mechanism of biliary secretion of membranous enzymes: bile acids are important factors for biliary occurrence of gamma-glutamyltransferase and other hydrolases. J Biochem (Tokyo) 1984; 96: 289-297.
    • (1984) J Biochem (Tokyo) , vol.96 , pp. 289-297
    • Hirata, E.1    Inoue, M.2    Morino, Y.3
  • 33
    • 0343963252 scopus 로고    scopus 로고
    • Chemical and biological activity of free radical 'scavengers' in allergic disease
    • Mates JM, Perez-Gomez C, Blanca M. Chemical and biological activity of free radical 'scavengers' in allergic disease. Clin Chim Acta 2000; 296: 1-15.
    • (2000) Clin Chim Acta , vol.296 , pp. 1-15
    • Mates, J.M.1    Perez-Gomez, C.2    Blanca, M.3
  • 34
    • 33646932475 scopus 로고    scopus 로고
    • The generation and actions of isoprostanes
    • Roberts U, Morrow JD. The generation and actions of isoprostanes. Biochim Biophys Acta 1997; 1345: 121-135.
    • (1997) Biochim Biophys Acta , vol.1345 , pp. 121-135
    • Roberts, U.1    Morrow, J.D.2
  • 35
    • 0032776363 scopus 로고    scopus 로고
    • Prognostic factors and long-term effects of ursodeoxycholic acid on liver biochemical parameters in patients with primary biliary cirrhosis
    • van Hoogstraten HJ, Hansen BE, van Buuren HR, ten Kate F, van Berge-Henegouwen GP, Schalm SW. Prognostic factors and long-term effects of ursodeoxycholic acid on liver biochemical parameters in patients with primary biliary cirrhosis. J Hepatol 1999; 31: 256-262.
    • (1999) J Hepatol , vol.31 , pp. 256-262
    • van Hoogstraten, H.J.1    Hansen, B.E.2    van Buuren, H.R.3    ten Kate, F.4    van Berge-Henegouwen, G.P.5    Schalm, S.W.6
  • 36
    • 0033869778 scopus 로고    scopus 로고
    • Pathogenesis of liver fibrosis: Role of oxidative stress
    • Poli G. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med 2000; 21: 49-98.
    • (2000) Mol Aspects Med , vol.21 , pp. 49-98
    • Poli, G.1
  • 37
    • 0028838193 scopus 로고
    • Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression
    • Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995; 96: 2461-2468.
    • (1995) J Clin Invest , vol.96 , pp. 2461-2468
    • Lee, K.S.1    Buck, M.2    Houglum, K.3    Chojkier, M.4
  • 38
  • 39
    • 0033658752 scopus 로고    scopus 로고
    • The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis
    • Corpechot C, Carrat F, Bonnand AM, Poupon RE, Poupon R. The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis. Hepatology 2000; 32: 1196-1199.
    • (2000) Hepatology , vol.32 , pp. 1196-1199
    • Corpechot, C.1    Carrat, F.2    Bonnand, A.M.3    Poupon, R.E.4    Poupon, R.5


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