High blood pressure and inflammation are associated with poor prognosis in lacunar infarctions

Cerebrovascular Diseases

Volumn 22, Issue 2-3, 2006, Pages 123-129

  Blanco, Miguel ^a   Castellanos, Mar ^b   Rodríguez Yáñez, Manuel ^a   Sobrino, Tomás ^a   Leira, Rogelio ^a   Vivancos, José ^c   Lizasoain, Ignacio ^d   Serena, Joaquín ^b   Dávalos, Antonio ^e   Castillo, José ^a  

^a University Hospital of Santiago de Compostela   (Spain)

^b HOSPITAL JOSEP TRUETA   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

High blood pressure; Inflammation; Interleukin 6; Lacunar infarction

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 6; NEUROTRANSMITTER;

ADULT; AGED; ARTICLE; BARTHEL INDEX; BRAIN INFARCTION; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE SEVERITY; EXCITOTOXICITY; FEMALE; GLUCOSE BLOOD LEVEL; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; HYPERTENSION; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEUROIMAGING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; RATING SCALE; SCORING SYSTEM; STATISTICAL ANALYSIS; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; SYMPTOMATOLOGY; SYSTOLIC BLOOD PRESSURE; TEMPERATURE;

AGED; BIOLOGICAL MARKERS; BLOOD PRESSURE; BRAIN INFARCTION; DISEASE PROGRESSION; FEMALE; HUMANS; HYPERTENSION; INFLAMMATION; INTERLEUKIN-6; MALE; PREDICTIVE VALUE OF TESTS; PROGNOSIS;

EID: 33746335629     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093240     Document Type: Article

References (37)

1. Bamford J, Sandercock P, Jones L, Warlow C: The natural history of lacunar infarction: the Oxfordshire Community Stroke Project. Stroke 1987;18:545-551.
2. Petty GW, Brown RD Jr, Whisnant JP, Sicks JD, O'Fallon WM, Wiebers DO: Ischemic stroke subtypes: a population-based study on incidence and risk factors. Stroke 1999;30:2513-2516.
3. Petty GW, Brown RD, Whisnant JP, Sicks JD, O'Fallon WM, Wiebers DO: Ischemic stroke subtypes. A population-based study of functional outcome, survival, and recurrence. Stroke 2000;31:1062-1068.
4. Fisher CM: Lacunar strokes and infarcts: a review. Neurology 1982;32:871-876.
5. Sacco RL, Wolf PA, Gorelick PB: Risk factors and their management for stroke prevention: outlook for 1999 and beyond. Neurology 1999;53(suppl 4):S15-S24.
6. Bamford J, Sandercock P, Dennis M, Burn J, Warlow C: Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 1991;337:1521-1526.
7. Clavier I, Hommel M, Besson G, Noèlle B, Ferjus Perret JE: Long-term prognosis of symptomatic lacunar infarcts: a hospital-based study. Stroke 1994;25:2005-2009.
8. Samuelsson M, Lindell D, Norrving B: Presumed pathogenetic mechanisms of recurrent stroke after lacunar infarction. Cerebrovasc Dis 1996;6:128-136.
9. Hier DB, Foulkes MA, Swiontoniowski M, Sacco RL, Gorelick PB, Mohr JP, Price TR, Wolf PA: Stroke recurrence within 2 years after ischemic infarction. Stroke 1991;22:155-161.
10. Bang OY, Joo SY, Lee PH, Joo US, Lee JH, Joo IS, Huh K: The course of patients with lacunar infarcts and a parent arterial lesion: similarities to large artery vs. small artery disease. Arch Neurol 2004;61:514-519.
11. Yokota C, Minematsu K, Hasegawa Y, Yamaguchi T: Long-term prognosis, by stroke subtypes, after a first-ever stroke: a hospital-based study over a 20-year period. Cerebrovasc Dis 2004;18:111-116.
12. Roquer J, Campello AR, Gomis M: Association of lacunar infarcts with small artery and large artery disease: a comparative study. Acta Neurol Scand 2004;110:350-354.
13. Samuelsson M, Söderfelt B, Olsson GB: Functional outcome in patients with lacunar infarction. Stroke 1996;27:842-46.
14. Appelros P, Samuelsson M, Lindell D: Lacunar Infarcts: functional and cognitive outcomes at five years in relation to MRI findings. Cerebrovasc Dis 2005;20:34-40
15. Norrving B: Long-term prognosis after lacunar infarction. Lancet Neurol 2003;2:238-245.
16. De Jong G, Kessels F, Lodder J: Two types of lacunar infarcts. Further arguments from a study on prognosis. Stroke 2002;33:2072-76.
17. Serena J, Leira R, Castillo J, Pumar JM, Castellanos M, Dávalos A: Neurological deterioration in acute lacunar infarctions. The role of excitatory and inhibitory neurotransmitters. Stroke 2001;32:1154-1161.
18. Castellanos M, Castillo J, García MM, Leira R, Serena J, Chamorro A, Dávalos A: Inflammation-mediated damage in progressing lacunar infarctions. A potential therapeutic target. Stroke 2002;33:982-987.
19. Waje-Andreassen U, Krakenes J, Ulvestad E et al: IL-6: an early marker for outcome in acute ischemic stroke. Acta Neurol Scand 2005;111:360-365.
20. Intiso D, Zarrelli MM, Lagioia G, Di Rienzo F, Checchia De Ambrosio C, Simone P, Tonali P, Cioffi Dagger RP: Tumor necrosis factor-α serum levels and inflammatory response in acute ischemic stroke patients. Neurol Sci 2004;24:390-396.
21. Tatu L, Moulin T, Bogousslavsky J, Duvernoy H: Arterial territories of the human brain: cerebral hemispheres. Neurology 1998;50:1699-1708.
22. Sluter G, Steen C, De Keyser J: Use of Barthel Index and modified Rankin Scale in acute stroke trials. Stroke 1999;30:1538-1541
23. Murat Sumer M, Erturk O: Ischemic stroke subtypes: risk factors, functional outcome and recurrence. Neurol Sci 2002;22:449-454.
24. Arauz A, Murillo L, Cantu C, Barinagarrementeria F, Higuera J: Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases. Stroke 2003;34:2453-2458.
25. Megherbi SE, Milan C, Minier D, Couvreur G, Osseby GV, Tilling K, Di Carlo A, Inzitari D, Wolfe CD, Moreau T, Giroud M, European BIOMED Study of Stroke Care Group: Association between diabetes and stroke subtype on survival and functional outcome 3 months after stroke: data from the European BIOMED Stroke Project. Stroke 2003;34:688-694.
26. Corea F, Tambasco N, Luccioli R, Ciorba E, Parnetti L, Gallai V: Brain CT-scan in acute stroke patients: silent infarcts and relation to outcome. Clin Exp Hypertens 2002;24:669-676.
27. Britton M, Carlsson A, de Faire V: Blood pressure course in patients with acute stroke and matched controls. Stroke 1986;17:861-864.
28. Carlberg B, Asplund K, Hagg E: The prognostic value of admission blood pressure in patients with acute stroke. Stroke 1993;24:1372-1375.
29. Danpani BK, Suzuki S, Kelley RE, Reyes-Iglesias Y, Duncan R: Relation between blood pressure and outcome in intracerebral hemorrhage. Stroke 1995;26:21-24.
30. Robinson T, Waddington A, Ward-Close S, Taub N, Potter J: The predictive role of 24-hour compared to casual blood pressure levels on outcome following acute stroke. Cerebrovasc Dis 1997;7:264-272.
31. Bath FJ, Bath PMW: What is the correct management of blood pressure in acute stroke? The blood pressure in Acute Stroke Collaboration. Cerebrovasc Dis 1997;7:205-213.
32. Di Napoli M, Papa F: Association between blood pressure and C-reactive protein levels in acute ischemic stroke. Hypertension 2003;42:1117-1123.
33. Engström G, Janzon L, Berglund G, Lind P, Stavenow L, Hedblad B, Lindgärde F: Blood pressure increase and incidence of hypertension in relation to inflammation-sensitive plasma proteins. Arterioscler Thromb Vasc Biol 2002;22:2054-2058.
34. Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, Ridker PM: C-reactive protein and the risk of developing hypertension. JAMA 2003;290:2945-2951.
35. Lee DL, Leite R, Fleming C, Pollock JS, Webb RC, Brands MW: Hypertensive response to acute stress is attenuated in interleukin-6 knockout mice. Hypertension 2004;44:259-263.
36. Di Napoli M, Papa F, Bocola V: C-reactive protein in ischemic stroke. An independent prognostic factor. Stroke 2001;32:917-924.
37. Di Napoli M, Papa F, Bocola V: Prognostic influence of increased c-reactive protein and fibrinogen levels in ischemic stroke. Stroke 2001;32:133-138.