A concise synthesis of 3′-α-fluoro-2′,3′-dideoxyguanosine (FddG) via 3′-α-selective fluorination of 8,2′-thioanhydronucleoside

Tetrahedron Letters

Volumn 47, Issue 34, 2006, Pages 6139-6141

  Torii, Takayoshi ^a   Onishi, Tomoyuki ^a   Izawa, Kunisuke ^a   Maruyama, Tokumi ^b  

^a AJINOMOTO CO INC   (Japan)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

3 Fluoro 2 ,3 dideoxyguanosine; Desulfurization; Neighboring effect; Stereoselective fluorination

Indexed keywords

3' ALPHA FLUORO 2',3' DIDEOXYGUANOSINE; ANTIVIRUS AGENT; NUCLEOSIDE DERIVATIVE; REAGENT; TOLUENE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; DESULFURIZATION; DRUG SYNTHESIS; FLUORINATION; ISOMER;

EID: 33746294078     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.06.074     Document Type: Article

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18. ′ are almost 0 Hz, the C3′ proton should be in the β configuration, and, therefore the fluorine atom at the C3′ position should be in the α configuration.
19. +), 784.2758, found 784.2765.
20. +), 754.3193, found 754.3221.
21. +), 270.1002, found 270.1011.