fMRI of fearful facial affect recognition in panic disorder: The cingulate gyrus-amygdala connection

Journal of Affective Disorders

Volumn 94, Issue 1-3, 2006, Pages 173-181

  Pillay, Srinivasan S ^a,b   Gruber, Staci A ^a,b   Rogowska, Jadwiga ^a,b   Simpson, Norah ^a,b   Yurgelun Todd, Deborah A ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Amygdala; Anxiety; Cingulate; Fear; fMRI; Panic

Indexed keywords

ADULT; AFFECT; AMYGDALOID NUCLEUS; ANXIETY; AROUSAL; ARTICLE; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTION; FACIAL EXPRESSION; FEAR; FEMALE; HUMAN; IMAGING SYSTEM; MALE; MENTAL PATIENT; NEUROIMAGING; PANIC; PRIORITY JOURNAL; RECOGNITION;

ADULT; AMYGDALA; AROUSAL; ATTENTION; BRAIN MAPPING; DOMINANCE, CEREBRAL; FACIAL EXPRESSION; FEAR; FEMALE; GYRUS CINGULI; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE NET; OXYGEN; PANIC DISORDER; PATTERN RECOGNITION, VISUAL;

EID: 33746242396     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2006.04.007     Document Type: Article

References (45)

1. Akiyoshi J., Hieda K., Aoki Y., and Nagayama H. Frontal brain hypoactivity as a biological substrate of anxiety in patients with panic disorders. Neuropsychobiology 47 (2003) 165-170
2. Anderson A.K., Christoff K., Panitz D., De Rosa E., and Gabrieli J.D. Neural correlates of the automatic processing of threat facial signals. J. Neurosci. 23 (2003) 5627-5633
3. Battaglia M., and Ogliari A. Anxiety and panic: from human studies to animal research and back. Neurosci. Biobehav. Rev. 29 (2005) 169-179
4. Benkelfat C., Bradwejn J., Meyer E., Ellenbogen M., Milot S., Gjedde A., and Evans A. Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers. Am. J. Psychiatry 152 (1995) 1180-1184
5. Boshuisen M.L., Ter Horst G.J., Paans A.M., Reinders A.A., and Den Boer J.A. rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest. Biol. Psychiatry 52 (2002) 126-135
6. Bouton M.E., Mineka S., and Barlow D.H. A modern learning theory perspective on the etiology of panic disorder. Psychol. Rev. 108 (2001) 4-32
7. Buchel C., Morris J., Dolan R.J., and Friston K.J. Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron 20 (1998) 947-957
8. Bystritsky A., Pontillo D., Powers M., Sabb F.W., Craske M.G., and Bookheimer S.Y. Functional MRI changes during panic anticipation and imagery exposure. NeuroReport 12 (2001) 3953-3957
9. Ehlers A., Margraf J., Taylor C.B., and Roth W.T. Cardiovascular Aspects of Panic Disorder (1988), Wiley, Chichester
10. Ekman P., and Friesen W.V. Pictures of facial affect. In: Press C.P. (Ed) (1976) Palo Alto, CA
11. Fichtenholtz H.M., Dean H.L., Dillon D.G., Yamasaki H., Mccarthy G., and LaBar K.S. Emotion-attention network interactions during a visual oddball task. Brain Res. Cogn. Brain Res. 20 (2004) 67-80
12. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM IV Axis 1 Disorders (SCID) (1996), New York State Psychiatric Institute, New York
13. Fischer H., Andersson J.L., Furmark T., and Fredrikson M. Brain correlates of an unexpected panic attack: a human positron emission tomographic study. Neurosci. Lett. 251 (1998) 137-140
14. Fischer H., Wright C.I., Whalen P.J., Mcinerney S.C., Shin L.M., and Rauch S.L. Brain habituation during repeated exposure to fearful and neutral faces: a functional MRI study. Brain Res. Bull. 59 (2003) 387-392
15. Friston K., Ashburner J., Poline J., Frith C., Heather J., and Frackowiak R. Spatial registration and normalization of images. Hum. Brain Mapp. 2 (1995) 165-169
16. Friston K., Holmes A., Worsley K., Poline J., Frith C., and Frackowiak R. Statistical parametric maps in functional imaging: a general approach. Hum. Brain Mapp. 2 (1995)
17. Gorman J.M., Kent J.M., Sullivan G.M., and Coplan J.D. Neuroanatomical hypothesis of panic disorder, revised. Am. J. Psychiatry 157 (2000) 493-505
18. Hamilton M. The assessment of anxiety states by rating. Br. J. Med. Psychol. 32 (1959) 50-55
19. Hariri A.R., Mattay V.S., Tessitore A., Fera F., and Weinberger D.R. Neocortical modulation of the amygdala response to fearful stimuli. Biol. Psychiatry 53 (2003) 494-501
20. Harmer C.J., Shelley N.C., Cowen P.J., and Goodwin G.M. Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition. Am. J. Psychiatry 161 (2004) 1256-1263
21. Holmes A., and Friston K. Generalisability, random effects and population inference. Neuroimage 7 (1998) s754
22. Javanmard M., Shlik J., Kennedy S.H., Vaccarino F.J., Houle S., and Bradwejn J. Neuroanatomic correlates of CCK-4-induced panic attacks in healthy humans: a comparison of two time points. Biol. Psychiatry 45 (1999) 872-882
23. Killgore W.D., and Yurgelun-Todd D.A. Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces. Neuroimage 21 (2004) 1215-1223
24. LaBar K.S., Crupain M.J., Voyvodic J.T., and Mccarthy G. Dynamic perception of facial affect and identity in the human brain. Cereb. Cortex 13 (2003) 1023-1033
25. Lautenbacher S., Spernal J., and Krieg J.C. Divided and selective attention in panic disorder. A comparative study of patients with panic disorder, major depression and healthy controls. Eur. Arch. Psychiatry Clin. Neurosci. 252 (2002) 210-213
26. Maddock R.J., Buonocore M.H., Kile S.J., and Garrett A.S. Brain regions showing increased activation by threat-related words in panic disorder. NeuroReport 14 (2003) 325-328
27. Maldjian J.A., Laurienti P.J., Kraft R.A., and Burdette J.H. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19 (2003) 1233-1239
28. Mcclure E.B., Monk C.S., Nelson E.E., Zarahn E., Leibenluft E., Bilder R.M., Charney D.S., Ernst M., and Pine D.S. A developmental examination of gender differences in brain engagement during evaluation of threat. Biol. Psychiatry 55 (2004) 1047-1055
29. McNally R.J. Psychological approaches to panic disorder: a review. Psychol. Bull. 108 (1990) 403-419
30. McNally R.J., Riemann B.C., Louro C.E., Lukach B.M., and Kim E. Cognitive processing of emotional information in panic disorder. Behav. Res. Ther. 30 (1992) 143-149
31. Monk C.S., McClure E.B., Nelson E.E., Zarahn E., Bilder R.M., Leibenluft E., Charney D.S., Ernst M., and Pine D.S. Adolescent immaturity in attention-related brain engagement to emotional facial expressions. Neuroimage 20 (2003) 420-422
32. Morris J.S., Friston K.J., Buchel C., Frith C.D., Young A.W., Calder A.J., and Dolan R.J. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain 121 Pt 1 (1998) 47-57
33. Morris J.S., Debonis M., and Dolan R.J. Human amygdala responses to fearful eyes. Neuroimage 17 (2002) 214-222
34. Nordahl T.E., Semple W.E., Gross M., Mellman T.A., Stein M.B., Goyer P., King A.C., Uhde T.W., and Cohen R.M. Cerebral glucose metabolic differences in patients with panic disorder. Neuropsychopharmacology 3 (1990) 261-272
35. Ogawa S., Menon R.S., Tank D.W., Kim S.G., Merkle H., Ellermann J.M., and Ugurbil K. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys. J. 64 (1993) 803-812
36. Pessoa L., Mckenna M., Gutierrez E., and Ungerleider L.G. Neural processing of emotional faces requires attention. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 11458-11463
37. Phillips M.L., Young A.W., Scott S.K., Calder A.J., Andrew C., Giampietro V., Williams S.C., Bullmore E.T., Brammer M., and Gray J.A. Neural responses to facial and vocal expressions of fear and disgust. Proc. R. Soc. London, Ser. B Biol. Sci. Biol. Sci. 265 (1998) 11809-11817
38. Phillips M.L., Medford N., Young A.W., Williams L., Williams S.C., Bullmore E.T., Gray J.A., and Brammer M.J. Time courses of left and right amygdalar responses to fearful facial expressions. Hum. Brain Mapp. 12 (2001) 193-202
39. Phillips M.L., Gregory L.J., Cullen S., Coen S., Ng V., Andrew C., Giampietro V., Bullmore E., Zelaya F., Amaro E., Thompson D.G., Hobson A.R., Williams S.C., Brammer M., and Aziz Q. The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation. Brain 126 (2003) 669-684
40. Pine D.S., Klein G., Mannuzza S., Moulton III J.L., Lissek S., Guardino M., and Woldehawariat G. Face-emotion processing in offspring at risk for panic disorder. J. Am. Acad. Child Adolesc. Psych. 44 (1999) 664-672
41. Pissiota A., Frans O., Michelgard A., Appel L., Langstrom B., Flaten M.A., and Fredrikson M. Amygdala and anterior cingulate cortex activation during affective startle modulation: a PET study of fear. Eur. J. Neurosci. 18 (2003) 1325-1331
42. Reiman E.M., Lane R.D., Ahern G.L., Schwartz G.E., Davidson R.J., Friston K.J., Yun L.S., and Chen K. Neuroanatomical correlates of externally and internally generated human emotion. Am. J. Psychiatry 154 (1997) 918-925
43. Smith M. Preparing fMRI Data for Statistical Analysis (2002), Oxford University Press
44. Spielberger C.D., Gorush R.L., and Lushene R.E. State-Trait Anxiety Inventory (1983), Consulting Psychologists Press, Inc., Palo Alto, CA
45. Whalen P.J., Shin L.M., Mcinerney S.C., Fischer H., Wright C.I., and Rauch S.L. A functional MRI study of human amygdala responses to facial expressions of fear versus anger. Emotion 1 (2001) 70-83