Synthesis and anticonvulsant activity of new N-1′,N-3′-disubstituted-2′H,3H,5′H-spiro-(2-benzofuran-1,4′-imidazolidine)-2′,3,5′-triones

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 17, 2006, Pages 4644-4647

  Patel, Hardik J ^a   Sarra, Joe ^a   Caruso, Francesco ^b   Rossi, Miriam ^c   Doshi, Utkarsh ^a   Stephani, Ralph A ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b CNR   (Italy)

^c VASSAR COLLEGE   (United States)

Author keywords

2 H,3H,5 H spiro (2 benzofuran 1,4 imidazolidine) 2 ,3,5 triones anticonvulsants; N,N substituted ureas; Ninhydrin; Sodium periodate; Spirohydantoins

Indexed keywords

ANTICONVULSIVE AGENT; BENZOFURAN DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN;

ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTICONVULSANTS; BENZOFURANS; IMIDAZOLIDINES; MICE; MOLECULAR STRUCTURE; PENTYLENETETRAZOLE; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746233391     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.102     Document Type: Article

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