Effect of dimethylsulfoxide on the convulsant properties of metrazol in mice

Research Communications in Biological Psychology and Psychiatry

Volumn 23, Issue 3-4, 1998, Pages 73-76

  Sarra, J D ^a   Stephani, R A ^b  

^a LONG ISLAND UNIVERSITY   (United States)

^b ST JOHN'S UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0007901952     PISSN: 10870695     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. De La Torre, J.C. (1970). Relative penetration of L-DOPA and 5-HTE through the blood brain barrier using dimethyl sulfoxide. Experientia 26: 1117-1118.
2. Fisher, R.S. (1989). Animal Models of Epilepsy. Brain Res. Rev. 14: 245-278.
3. Guerts, M.; Poupaert, J.H.; Scriba, G.K.E.; Lambert, D.M. (1998). N-(Benzyloxy carbonyl) glycine esters and amides as new anticonvulsants. J. Med. Chem. 41: 24-30.
4. Iwen, P.C. and Miller, N.G. (1986). Enhancement of ketoconazole penetration across the blood brain barrier of mice by dimethyl sulfoxide. Antimicrob. Agents Chemother. 30: 617-618.
5. Mori, N., Wada, J.A., Sato, T., Saito, H. and Kumashiro, H. (1992). Important roles of N-methyl-D-aspartate receptors in expression of amygdaloid-kindled seizure demonstrated by intraperitoneal administration of L-aspartate in dimethyl sulfoxide. Epilepsia 33:583-588.
6. th Edn., The Pharmaceutical Press, London, p. 1101-1102.
7. Sarra, J.D. and Stephani, R.A. unpublished results.
8. Scriba, G.K.E., Lambert, D.M and Poupaert, J.H. (1995). Anticonvulsant activity of phenytoin-lipid conjugates, a new class of phenytoin prodrugs. J. Pharm. Pharmacol. 47: 197-203.
9. Swinyard, E.A., Brown, W.C. and Goodman, L.S. (1952). Comparative assays of antiepiletic drugs in mice and rats. J. Pharmacol. Exp. Ther. 106: 319-330.
10. Vida, J.A. (1995). Anticonvulsants. In: Principles of Medicinal Chemistry Edited by Foye, W.A., Lemke, T.L. and Williams, D.A., 4th ed. Williams and Wilkins. Media, PA. USA. p. 186.