Fall and rise of behavioural pharmacology

Drug Discovery Today: Technologies

Volumn 3, Issue 2, 2006, Pages 181-185

  de Graaf, Joop S ^a  

^a European Summer School for Whole Animal Pharmacology   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIOR CHANGE; BEHAVIORAL RESEARCH; CLINICAL PRACTICE; DRUG RESEARCH; ECONOMIC ASPECT; GENETIC ENGINEERING; HISTORY OF MEDICINE; IN VIVO STUDY; MEDICAL TECHNOLOGY; NONHUMAN; POLITICS; PSYCHOGENESIS; REVIEW;

EID: 33746215909     PISSN: 17406749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddtec.2006.06.007     Document Type: Review

References (22)

1. Clark A.J. The reaction between Acetyl Choline and muscle cells. J. Physiol. (London) 61 (1926) 530
2. Clark A.J. The antagonism of Acetyl Choline by Atropine. J. Physiol. (London) 61 (1926) 547
3. Koshland Jr. D.E. Application of a theory of enzyme specificity to protein synthesis. Proc. Natl. Acad. Sci. U S A 44 (1958) 98-104
4. Koshland Jr. D.E. The key-lock theory and the induced fit theory. Angewandte Chemie International Edition in English 33 (1995) 2375-2378
5. Black J.W., and Stephenson J.S. Pharmacology of a new adrenergic beta-blocking compound. Lancet 2 (1962) 311-314
6. 2-receptor antagonists. Gastroenterology 105 (1993) 963-968
7. Fell P.J., et al. The human pharmacology of GB 94 - a new psychotropic agent. Eur. J. Clin. Pharmacol. 78 (1973) 756-769
8. Einstein S. The "social chemistry" of pharmacological discovery: the haloperidol story. An interview with Dr. Paul Janssen. Int. J. Addict. 27 (1992) 331-346
9. Maehle A.H., et al. The emergence of the Drug Receptor Theory. Nat. Rev., Drug Discov. 1 (2002) 637-641
10. Lazar J., et al. Impact of genomics on research in the rat. Genome. Res. 15 (2005) 1717-1728
11. Smits B.G.J., et al. Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenetics Genomics 16 (2006) 159-169
12. de Graaf J.S., et al. A set of behavioural tests predicting antidepressant activity. Drug Dev. Res. 5 (1985) 291-301
13. de Graaf J.S., et al. Fully automated experiments with isolated organs in vitro. J. Pharmacol. Methods 10 (1983) 113-124
14. Seeman P., et al. Brain receptors for antipsychotic drugs and dopamine: Direct binding assays. Proc. Nat. Acad. Sci. U S A 72 (1975) 4376-4380
15. Seeman P., et al. Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261 (1976) 717-719
16. Hendriksen C.F.M., and Koëter H.B.W.M. Animals in biomedical research. Replacement, Reduction and Refinement: Present Possibilities and Future Prospects (1991), Elsevier. 0-444-81417-5
17. Waddington J.L., et al. Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insight and challenges from 10 years at the psychopharmacology-molecular biolology interface. Psychopharmacology 181 (2005) 611-638
18. Ruigt G.S.F., et al. A Large-scale high resolution automated system for rat sleep staging (I) methodology and technical aspects. Electroencephal. Clin. Neurophysiol. 73 (1989) 52-63
19. Ruigt G.S.F., et al. A large-scale high resolution automated system for rat sleep staging (II) validation and allpication. Electroencephal. Clin. Neurophysiol. 73 (1989) 64-71
20. Ruigt G.S.F., et al. Computer-based prediction of psychotropic drug classes based on a discriminant analysis of drug effects on rat sleep. Neuropsychobiology 28 (1993) 138-153
21. Spruijt, B.M. and De Visser, L. (this issue) Advanced behavioural screening: automated home cage ethology, Drug Discov. Today: Technol.
22. Paton W.D.M. On becoming and being a Pharmacologist. Ann. Rev. Pharmacol. Toxicol. 26 (1986) 1-8