In vitro anti-tumor immune response induced by dendritic cells transfected with EBV-LMP2 recombinant adenovirus

Biochemical and Biophysical Research Communications

Volumn 347, Issue 3, 2006, Pages 551-557

  Pan, Ying ^a   Zhang, Jinkun ^a   Zhou, Ling ^b   Zuo, Jianmin ^b   Zeng, Yi ^b  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Cancer vaccine; Cytotoxic T lymphocyte; Dendritic cell; Epstein Barr virus; Gene transfer; Nasopharyngeal carcinoma

Indexed keywords

ADENOVIRUS VECTOR; CANCER VACCINE; LATENT MEMBRANE PROTEIN 2;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL BASED GENE THERAPY; CELL PROLIFERATION; CYTOTOXICITY; DENDRITIC CELL; EPSTEIN BARR VIRUS; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOTHERAPY; MORPHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINATION;

ADENOVIRIDAE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CELLS, CULTURED; DENDRITIC CELLS; GENE EXPRESSION; HERPESVIRUS 4, HUMAN; HUMANS; NEOPLASMS; PHENOTYPE; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TRANSFECTION; VIRAL MATRIX PROTEINS;

ADENOVIRIDAE; HUMAN HERPESVIRUS 4;

EID: 33746215071     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.05.214     Document Type: Article

References (28)

1. Niedobitek G. Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma. J. Clin. Pathol. 53 (2000) 248-254
2. Steinman R.M. The dendritic cell system and its role in immunogenicity. Ann. Rev. Immunol. 9 (1991) 271-296
3. Banchereau J., and Steinman R. Dendritic cells and the control of immunity. Nature (Lond.) 392 (1998) 245-252
4. Tomohide T., Andrea G., Paul D.R., and Walter J.S. Interleukin 18 gene transfer expands the repertoire of antitumor Th1-type immunity elicited by dendritic cell-based vaccines in association with enhanced therapeutic efficacy. Cancer Res. 62 (2002) 5853-5858
5. + T cells for efficient tumor cell lysis. Cancer Res. 60 (2000) 4446-4452
6. Nouri-Shirazi M., Banchereau J., Bell D., et al. Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. J. Immunol. 165 (2000) 3797-3803
7. Bagley K.C., Abdelwahab S.F., Tuskan R.G., and Lewis G.K. Calcium signaling through phospholipase C activates dendritic cells to mature and is necessary for the activation and maturation of dendritic cells induced by diverse agonists. Clin. Diagn. Lab. Immunol. 11 (2004) 77-82
8. Sadovnikova E., Parovichnikova E.N., Semikina E.L., et al. Adhesion capacity and integrin expression by dendritic-like cells generated from acute myeloid leukemia blasts by calcium ionophore treatment. Exp. Hematol. 32 (2004) 563-570
9. Du H.J., Zhou L., Zuo J.M., et al. A study on killing effect of cytotoxic T cell activated by LMP2 peptides in nasopharyngeal carcinoma cells. J. Oncol. 10 (2004) 92-94
10. Rosenfeld M.A., Yoshimura K., Trapnell B.C., et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68 (1992) 143-155
11. Mittereder N., March K.L., and Trapnell B.C. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J. Virol. 70 (1996) 7498-7509
12. Gottschalk S., Edwards O.L., Sili U., et al. Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies. Blood 101 (2003) 1905-1912
13. Wagner H.J., Sili U., Gahn B., et al. Expansion of EBV latent membrane protein 2a specific cytotoxic T cells for the adoptive immunotherapy of EBV latency type 2 malignancies: influence of recombinant IL12 and IL15. Cytotherapy 5 (2003) 231-240
14. + T cell response. J. Immunol. 170 (2003) 5195-5202
15. Westers T.M., Stam A.G., Scheper R.J., et al. Rapid generation of antigen-presenting cells from leukaemic blasts in acute myeloid leukaemia. Cancer Immunol. Immunother. 52 (2003) 17-27
16. Waclavicek M., Berer A., Oehler L., et al. Calcium ionophore: a single reagent for the differentiation of primary human acute myelogenous leukaemia cells towards dendritic cells. Br. J. Haematol. 114 (2001) 466-473
17. Diebold S.S., Cotten M., Koch N., and Zenke M. MHC class II presentation of endogenously expressed antigens by transfected dendritic cells. Gene Ther. 8 (2001) 487-493
18. Paul L.F., Christie L., Jennifer M.A., et al. Efficacy of CD40 ligand gene therapy in malignant mesothelioma. Am. J. Resp. Cell Mol. Biol. 29 (2003) 321-330
19. Jay M.L., Ali M., Reiko Y., et al. Adenovirus vector-mediated overexpression of a truncated form of the p65 nuclear factor κB cDNA in dendritic cells enhances their function resulting in immune-mediated suppression of preexisting murine tumors. Clin. Cancer Res. 8 (2002) 3561-3569
20. Khanna R., and Burrows S.R. Role of cytotoxic T lymphocytes in Epstein-Barr virus-associated diseases. Annu. Rev. Microbiol. 54 (2000) 19-48
21. Burrows J.M., Bromham L., Woolfit M., et al. Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from Southeast Asia. J. Virol. 78 (2004) 7131-7137
22. Munz C., Bickham K.L., and Subklewe M. Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1. J. Exp. Med. 191 (2000) 1649-1660
23. Khanna R., Tellam J., Duraiswamy J., et al. Immunotherapeutic strategies for EBV-associated malignancies. Trends Mol. Med. 7 (2001) 270-276
24. + T-cell immunity and may lead to tumor regression in patients with EBV-positive nasopharyngeal carcinoma. Cancer Res. 62 (2002) 6952-6958
25. +-T-cell responses by a chimeric antigen construct: potential therapeutic vaccine for EBV-positive nasopharyngeal carcinoma. J. Virol. 78 (2004) 768-778
26. Bollard C.M., Straathof K.C., Huls M.H., et al. The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease. J. Immunother. 27 (2004) 317-327
27. Chua D., Huang J., Zheng B., et al. Adoptive transfer of autologous Epstein-Barr virus-specific cytotoxic T cells for nasopharyngeal carcinoma. Int. J. Cancer. 94 (2001) 73-80
28. Herr W., Ranieri E., Olson W., et al. Mature dendritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4(+) and CD8(+) T lymphocyte responses. Blood 96 (2000) 1857-1864