Le lactate est-il un substrat énergétique majeur pour les neurones?

Medecine/Sciences

Volumn 22, Issue 4, 2006, Pages 356-357

  Costalat, Robert ^a   Aubert, Agnès ^b   Magistretti, Pierre J ^c   Pellerin, Luc ^b  

^a SORBONNE UNIVERSITÉ   (France)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID DERIVATIVE; MONOCARBOXYLATE TRANSPORTER;

ANIMAL; ARTICLE; ASTROCYTE; BIOLOGICAL MODEL; BRAIN; CYTOLOGY; ENERGY METABOLISM; HUMAN; KINETICS; METABOLISM; NERVE CELL; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING;

ANIMALS; ASTROCYTES; BRAIN; ENERGY METABOLISM; HUMANS; KINETICS; LACTATES; MODELS, NEUROLOGICAL; MONOCARBOXYLIC ACID TRANSPORTERS; NEURONS; POSITRON-EMISSION TOMOGRAPHY;

EID: 33746196818     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/2006224356     Document Type: Article

References (10)

1. Siesjö BK. Brain energy metabolism. New York: Wiley, 1978.
2. Fox PT, Raichle ME. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 1986; 83: 1140-4.
3. 1H NMR in human visual cortex during physiologic stimulation. Proc Natl Acad Sci USA 1991; 88:5829-31.
4. Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 1994; 91: 10625-9.
5. Dienel GA, Cruz NF. Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought ? Neurochem Int 2004; 45: 321-51.
6. Aubert A, Costalat R. Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism. Cereb Blood Flow Metab 2005; 25: 1476-90.
7. Aubert A, Costalat R, Magistretti PJ, Pellerin L. Brain lactate kinetics: modeling evidence for neuronal lactate uptake upon activation. Proc Natl Acad Sci USA 2005; 102: 16448-53.
8. Hu Y, Wilson GS. A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J Neurochem 1997; 69: 1484-90.
9. Mangia S, Garreffa G, Bianciardi M, et al. The aerobic brain: lactate decrease at the onset of neural activity. Neuroscience 2003; 118: 7-10.
10. Porras OH, Loaiza A, Barros LF. Glutamate mediates acute glucose transport inhibition in hippocampal neurons. J Neurosci 2004; 24: 9669-73.