Catalytic asymmetric synthesis of α,α,α- trifluoromethylamines by the copper-catalyzed nucleophilic addition of diorganozinc reagents to imines

Organic Letters

Volumn 8, Issue 13, 2006, Pages 2743-2745

  Lauzon, Caroline ^a   Charette, André B ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33746144110     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0607847     Document Type: Article

References (34)

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30. 4: 23% yield of ketimine.
31. 4, an efficient reagent for the preparation of N-tosylimines led to a 15% yield of the hemiaminal: Love, B. E.; Raje, P. S.; Williams, T. C., II. Synlett 1994, 7, 493.
32. 4. Concentration and purification by flash chromatography gave the hemiaminal as a colorless white solid. The residual ketone could be isolated in the first few fractions of the chromatography.
33. 4 and concentrated under reduced pressure, and the residue was purified by flash chromatography to give the corresponding addition product as a white solid.
34. 2O (1 M) (4.46 mmol, 10.0 equiv) to give a white solid.