Physico-chemical profiling of antidepressive sertraline: Solubility, ionisation, lipophilicity

Medicinal Chemistry

Volumn 2, Issue 4, 2006, Pages 385-389

  Deák, Katalin ^a   Takács Novaák, Krisztina ^b   Tihanyi, Károly ^a   Noszál, Béla ^b  

^a GEDEON RICHTER LTD   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

logP; logS; Pharmacokinetics; Physico chemical profiling; pKa; Sertraline

Indexed keywords

ALKANE; ANTIDEPRESSANT AGENT; METHANOL; OCTANOL; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; SOLVENT; WATER;

ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; IONIZATION; LIPOPHILICITY; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; POTENTIOMETRY; PRIORITY JOURNAL; THERMODYNAMICS;

ANTIDEPRESSIVE AGENTS; CHEMISTRY, PHYSICAL; CYCLOHEXANES; KINETICS; OCTANOLS; POTENTIOMETRY; PROTONS; SERTRALINE; SOLUBILITY; SOLVENTS; THERMODYNAMICS; WATER;

EID: 33746107181     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340606777723997     Document Type: Article

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