Class II transactivator-mediated regulation of major histocompatibility complex class II antigen expression is important for hematopoietic progenitor cell suppression by chemokines and iron-binding proteins

Experimental Hematology

Volumn 34, Issue 8, 2006, Pages 1078-1084

  Broxmeyer, Hal E ^a   Cooper, Scott ^a   Hangoc, Giao ^a   Chang, Cheong Hee ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; BETA CHEMOKINE; CHEMOKINE; ERYTHROPOIETIN; GAMMA INTERFERON; H FERRITIN; HEMIN; HLA ANTIGEN CLASS 2; IRON BINDING PROTEIN; LACTOFERRIN; POKEWEED MITOGEN; STEM CELL FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLASS II TRANSACTIVATOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CELL CYCLE S PHASE; COLONY FORMATION; CONTROLLED STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN CELL; STATISTICAL SIGNIFICANCE;

ANIMALS; APOFERRITINS; CHEMOKINES; FERRITINS; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTERFERON TYPE II; MICE; NUCLEAR PROTEINS; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE; PHYTOLACCACEAE;

EID: 33746076713     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.04.008     Document Type: Article

References (39)

1. Shaheen M., and Broxmeyer H.E. The humoral regulation of hematopoiesis. In: Hoffman R., Benz E., Shattil S., et al. (Eds). Hematology: Basic Principles and Practice. 4th ed. (2005), Churchill Livingstone, Philadelphia, PA 233-265
2. Graham G.J., and Pragnell I.B. Negative regulators of haemopoiesis-current advances. Prog Growth Factor Res 2 (1990) 181-192
3. Plumb M., Graham G.J., Grove M., Reid A., and Pragnell I.B. Molecular aspects of a negative regulator of haemopoiesis. Br J Cancer 64 (1991) 990-992
4. Broxmeyer H.E. Myelosuppressive cytokines and peptides. In: Whetton T., and Gordon T. (Eds). Blood Cell Biochemistry, Vol. 7: Hemopoietic Growth Factors (1996), Plenum, London 121-150
5. Broxmeyer H.E., and Kim C.H. Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities. Exp Hematol 27 (1999) 1113-1123
6. Broxmeyer H.E. Regulation of hematopoiesis by chemokine family members. Int J Hematol 74 (2001) 9-17
7. +++ stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum. Exp Hematol 21 (1993) 1442-1446
8. Broxmeyer H.E., Cooper S., Hangoc G., and Kim C.H. Stromal cell derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. Stem Cell Dev 14 (2005) 199-203
9. Broxmeyer H.E. Relationship of cell-cycle expression of Ia-like antigen determinants on normal and leukemia human granulocyte-macrophage progenitor cells to regulation in vitro by acidic isoferritins. J Clin Invest 69 (1982) 632-642
10. Pelus L.M. Association between colony forming units-granulocyte macrophage expression of Ia-like (HLA-DR) antigen and control of granulocyte and macrophage production. A new role for prostaglandin E. J Clin Invest 70 (1982) 568-578
11. Lu L., Broxmeyer H.E., Meyers P.A., Moore M.A.S., and Thaler H.T. Association of cell cycle expression of Ia-like antigenic determinants on normal human multipotential (CFU-GEMM) and erythroid (BFU-E) progenitor cells with regulation in vitro by acidic isoferritins. Blood 61 (1983) 250-256
12. Lu L., Pelus L.M., and Broxmeyer H.E. Modulation of expression of HLA-DR (Ia) antigens and the proliferation of human erythroid (BFU-E) and multipotential (CFU-GEMM) progenitor cells by prostaglandin E. Exp Hematol 12 (1984) 741-748
13. Broxmeyer H.E. Detection of Ia-antigens for I-A and I-E/C subregions on mouse granulocyte-macrophage progenitor cells during DNA-synthesis: association with the action of acidic isoferritins in vitro. J Immunol 129 (1982) 1002-1007
14. Broxmeyer H.E., and Platzer E. Lactoferrin acts on I-A and I-E/c antigen-positive subpopulations of mouse peritoneal macrophages in the absence of T-lymphocytes and other cell types to inhibit production of granulocyte-macrophage colony stimulatory factors in vitro. J Immunol 133 (1984) 306-314
15. Piacibello W., Rubin B.Y., and Broxmeyer H.E. Prostaglandin E counteracts modulation of the gamma interferon induction of Ia antigens on U937 cells and induction of responsiveness of U937 colony forming cells to suppression by lactoferrin, transferrin, acidic isoferritins and prostaglandin E. Exp Hematol 14 (1986) 44-50
16. Broxmeyer H.E., Piacibello W., Juliano L., Platzer E., Berman E., and Rubin B.Y. Gamma interferon induces colony forming cells of the human monoblast cell line U937 to respond to inhibition by lactoferrin, transferrin and acidic isoferritins. Exp Hematol 14 (1986) 35-43
17. LeibundGut-Landmann S., Waldburger J.M., Krawczyk M., et al. Specificity and expression of CIITA, the master regulator of MHC class II genes. Eur J Immunol 34 (2004) 1513-1525
18. Chang C.C., Guerder S., Hong S.-C., van Ewijk W., and Flavell R.A. Mice lacking the MHC class II transactivator (CIITA) show tissue specific impairment of MHC class II expression. Immunity 4 (1996) 167-178
19. Cosgrove D., Gray D., Dierich A., et al. Mice lacking MHC class II molecules. Cell 66 (1991) 1051-1066
20. Grusby M.J., Johnson R.S., Papaioannov V.E., and Glimcher L.H. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 253 (1991) 1417-1420
21. Gourley T., Roys S., Luckas N., Kunkel S., Flavell R.A., and Chang C.C. A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. Immunity 10 (1999) 377-386
22. Broxmeyer H.E., Cooper S., Levi S., and Arosio P. Mutated recombinant human heavy-chain ferritins and myelosuppression in vitro and in vivo: a link between ferritin ferroxidase activity and biological function. Proc Natl Acad Sci U S A 88 (1991) 770-774
23. Cooper S., and Broxmeyer H.E. Clonogenic methods in vitro for the enumeration of granulocyte-macrophage progenitor cells (CFU-GM) in human bone marrow and mouse bone marrow and spleen. J Tissue Cult Methods 13 (1991) 77-82
24. Cooper S., and Broxmeyer H.E. Measurement of interleukin-3 and other hematopoietic growth factors, such as GM-CSF, G-CSF, M-CSF, erythropoietin and the potent co-stimulating cytokines steel factor and Flt-3 ligand. In: Coligan J.E., Kruisbeek A.M., Margulies D.H., Shevach E.M., Strober W., and Coico R. (Eds). Current Protocols in Immunology. Suppl 18 (1996), John Wiley & Sons, New York 6.4.1-6.4.12
25. Broxmeyer H.E., Sherry B., Cooper S., et al. Comparative analysis of the suppressive effects of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. J Immunol 150 (1993) 3448-3458
26. Mantel C., Kim Y.-J., Cooper S., Kwon B., and Broxmeyer H.E. Polymerization of murine macrophage inflammatory protein-1α inactivates its myelosuppressive effects in vitro. The active form is monomer. Proc Natl Acad Sci U S A 90 (1993) 2232-2236
27. Broxmeyer H.E., Cooper S., Hague N., et al. Human chemokines: enhancement of specific activity and effects in vitro on normal and leukemic progenitors and a factor dependent cell line and in vivo in mice. Ann Hematol 71 (1995) 235-246
28. Ottersbach K., Cook D.N., Kuziel W.A., et al. Macrophage inflammatory protein-1alpha uses a novel receptor for primitive hemopoietic cell inhibition. Blood 98 (2001) 3476-3478
29. Broxmeyer H.E., Cooper S., Cacalano G., et al. Interleukin-8 receptor is involved in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homolog. J Exp Med 184 (1996) 1825-1832
30. Kim C.H., Qu C.K., Hangoc G., Cooper S., Feng G.S., and Broxmeyer H.E. Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicates the protein tyrosine phosphatase SHP-1 in chemokine responses. J Exp Med 190 (1999) 681-690
31. Kim C.H., Hangoc G., Cooper S., et al. Altered responsiveness to chemokines due to targeted disruption of SHIP. J Clin Invest 104 (1999) 1751-1759
32. Kaplan M.H., Chang C.-H., Cooper S., Lee Y.H., and Broxmeyer H.E. Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines. J Hematotherapy & Stem Cell Res 12 (2003) 401-408
33. Reith W., and Mach B. The bare lymphocyte syndrome and the regulation of MHC expression. Annu Rev Immunol 19 (2001) 331-373
34. Sheridan C., Sadarea M., Bhat-Nakshatri P., et al. Negative regulation of MHS Class II gene expression by CXCR4. Exp Hematol 34 (2006) 1085-1092
35. Maze R., Sherry B., Kwon B.S., Cerami A., and Broxmeyer H.E. Myelosuppressive effects in vivo of purified recombinant murine macrophage inflammatory protein-1 alpha. J Immunol 149 (1992) 1004-1009
36. Cooper S., Mantel C., and Broxmeyer H.E. Myelosuppressive effects in vivo with very low dosage of monomeric recombinant murine macrophage inflammatory protein-1α. Exp Hematol 22 (1994) 186-193
37. Dunlop D.J., Wright E.G., Lorimore S., et al. Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo. Blood 79 (1992) 2221-2225
38. Lord B.I., Dexter T.M., Clements J.M., Hunter M.A., and Gearing A.J. Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo. Blood 79 (1992) 2605-2609
39. Broxmeyer H.E., Pelus L.M., Kim C., Hangoc G., Cooper S., and Hromas R. Synergistic inhibition in vivo of bone marrow myeloid progenitors by myelosuppressive chemokines, and chemokine accelerated recovery of progenitors after treatment of mice with Ara-C. Exp Hematol 34 (2006) 1069-1077