An agglutinin with mitogenic and antiproliferative activities from the mushroom Flammulina velutipes

Mycologia

Volumn 98, Issue 2, 2006, Pages 167-171

  Ng, T B ^a   Ngai, Patrick H K ^a   Xia, Lixin ^a,b  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b SHENZHEN UNIVERSITY   (China)

Author keywords

Agglutinin; Flammulina velutipes; Isolation; Mushroom

Indexed keywords

FUNGAL PROTEIN; HEMAGGLUTININ; LECTIN; MITOGENIC AGENT; THYMIDINE; TRITIUM;

IMMUNOASSAY; MUSHROOM; PROTEIN; TEMPERATURE EFFECT;

AGARICALES; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ERYTHROCYTE; FRUITING BODY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; RABBIT; SPLEEN; TUMOR CELL LINE;

AGARICALES; AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; ERYTHROCYTES; FRUITING BODIES, FUNGAL; FUNGAL PROTEINS; HEMAGGLUTININS; HUMANS; LECTINS; MICE; MICE, INBRED BALB C; MITOGENS; MOLECULAR SEQUENCE DATA; RABBITS; SPLEEN; THYMIDINE; TRITIUM;

BASIDIOMYCOTA; FLAMMULINA VELUTIPES;

EID: 33746066699     PISSN: 00275514     EISSN: 00275514     Source Type: Journal    
DOI: 10.3852/mycologia.98.2.167     Document Type: Article

References (45)

1. Batterbury M, Tebbs CA, Rhodes JM, Grierson I. 2002. Agaricus bisporus (edible mushroom lectin) inhibits ocular fibroblast proliferation and collagen lattice contraction. Exp Eye Res 74:361-370.
2. Brechtel R, Watzig H, Rudiger H. 2001. The lectin from the mushroom Pleurotus ostreatus: a phosphatase-activating protein that is closely associated with an α-galactosidase activity. Plant Sci 160:1025-1033.
3. Charan RD, Munro MH, O'Keefe BR, Sowder RCII, McKee TC, Currens MJ, Pannell LK, Boyd MR. 2000. Isolation and characterization of Myrianthus holstii lectin, a potent HIV-1 inhibitory protein from the plant Myrianthus holstii. J Nat Prod 63:1170-1174.
4. Ciopraga J, Gozia O, Tudor R, Brezuica L, Doyle RJ. 1999. Fusarium sp. growth inhibition by wheat germ agglutinin. Biochim Biophys Acta 1428:424-432.
5. Conrad F, Rudiger H. 1994. The lectin from Pleurotus ostreatus: Purification, characterization and interaction with a phosphatase. Phytochem 36:277-283.
6. Corbeau P, Haran M, Binz H, Devaux C. 1994. Jacalin, a lectin with anti-HIV-1 properties, and HIV-1 gp120 envelope protein interact with distinct regions of the CD4 molecule. Mol Immunol 31:569-575.
7. Crenshaw RW, Harper SN, Moyer M, Privalle LS. 1995. Isolation and characterization of a cDNA clone encoding a lectin gene from Agaricus bisporus. Plant Physiol 107:1465-1466.
8. Eifler R, Ziska P. 1980. The lectins from Agaricus edulis. Isolation and characterization. Experientia 36:1285-1286.
9. Gozia O, Ciopraga J, Bentia T, Lungu M, Zamfirescu I, Tudor R, Roseanu A, Nitu F. 1993. Antifungal properties of lectin and new chitinases from potato tubers. Acad Sci 316:788-792.
10. Hansen JE, Nielsen C, Vestergaard BF. 1991. Inhibition of human immunodeficiency virus 1 (HIV-1) and herpes simplex virus 1 (HSV-1) infectivity with a broad range of lectins. Scand J Infect Dis 23:425-430.
11. Hsu HC, Hsu CI, Lin RH, Kao CL, Lin JY. 1997. Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea. Biochem J 323:557-565.
12. Ikekawa T, Ikeda Y, Yoshioka Y, Nakanishi K, Yokoyama E, Yamazaki E. 1982. Studies on antitumor polysaccharides of Flammulina velutipes (Curt. ex Fr.) Sing.II. The structure of EA3 and further purification of EA5. J Pharmacobiodyn 5:576-581.
13. Kawagishi H, Mitsunaga SI, Yamawaki M, Ido M. A. Shimada, T. Kinoshita, T. Murata, T. Usui, A. Kimura, S. Chiba. 1997. A lectin from mycelia of the fungus Ganoderma lucidum. Phytochem 44:7-10.
14. _, Mori H, Uno A, Kimura A, Chiba S. 1994. A sialic acid-binding lectin from the mushroom Hericium erinaceum. FEBS Lett 340:56-58.
15. _, Nomura A, Mizuno T, Kimura A, Chiba S. 1990. Isolation and characterization of a lectin from Grifola frondosa fruiting bodies. Biochim Biophys Acta 1034:247-252.
16. _, Yumen T, Mizuno T. 1988. Isolation and properties of a lectin from the fruiting bodies of Agaricus blazei. Carbohydr Res 183:150-154.
17. Kent D, Sheridan CM, Tomkinson HA, White SJ, Hiscott P, Yu L, Grierson I. 2003. Edible mushroom (Agaricus bisporus) lectin inhibits human retinal pigment epithelial cell proliferation in vitro. Wound Repair Regen 11:285-291.
18. Ko JL, Hsu CT, Lin RH, Kao CL, Lin JY. 1995. A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence. Eur J Biochem 228:244-249.
19. Laemmli UK, Favre M. 1973. Gel electrophoresis of proteins. J Mol Biol 80:573-599.
20. Leung MY, Fung KP, Choy YM. 1997. The isolation and characterization of an immunomodulatory and antitumor polysaccharide preparation from Flammulina velutipes. Immunopharmacology 35:255-263.
21. Lopez S, Armand-Ugon M, Bastida J, Viladomat F, Este JA, Stewart D, Codina C. 2003. Anti-human immunodeficiency virus type 1 (HIV-1) activity of lectins from Narcissus species. Planta Med 69:109-112.
22. Mahajan RG, Patil SI, Mohan DR, Shastry P. 2002. Pleurotus eous mushroom lectin (PEL) with mixed carbohydrate inhibition and antiproliferative activity on tumor cell lines. J Biochem Mol Biol Biophys 6:341-345.
23. Ng TB, Wang HX. 2004. Flammin and velin: new ribosome inactivating polypeptides from the mushroom Flammulina velutipes. Peptides 25:929-933.
24. Ngai PH, Ng TB. 2004. A mushroom (Ganoderma capense) lectin with spectacular thermostability, potent mitogenic activity on splenocytes, and antiproliferative activity toward tumor cells. Biochem Biophys Res Commun 314:988-993.
25. Otagiri K, Ohkuma T, Ikekawa T, Tanaka S. 1983. Intensification of antitumor-immunity by protein-bound polysaccharide, EA6, derived from Flammulina velutipes (Curt. ex Fr.) Sing. combined with murine leukemia L1210 vaccine in animal experiments. J Pharmacobiodyn 6:96-104.
26. Parslew R, Jones KT, Rhodes JM, Sharpe GR. 1999. The antiproliferative effect of lectin from the edible mushroom (Agaricus bisporus) on human keratinocytes: preliminary studies on its use in psoriasis. Br J Dermatol 140:56-60.
27. Sage HJ, Vazquez JJ. 1967. Studies on a hemagglutinin from the mushroom Agaricus campestris. J Biol Chem 242:120-125.
28. She QB, Ng TB, Liu WK. 1998. A novel lectin with potent immunomodulatory activity isolated from both fruiting bodies and cultured mycelia of the edible mushroom Volvariella volvacea. Biochem Biophys Res Commun 247:106-111.
29. Tsuda M. 1979. Purification and characterization of a lectin from the mushroom, Flammulina velutipes. J Biochem 86:1463-1468.
30. Wang H, Gao J, Ng TB. 2000. A new lectin with highly potent antihepatoma and antisarcoma activities from the oyster mushroom Pleurotus ostreatus. Biochem Biophys Res Commun 275:810-816.
31. _, Ng TB. 2001. Isolation and characterization of velutin, a novel low-molecular-weight ribosome-inactivating protein from winter mushroom (Flammulina velutipes) fruiting bodies. Life Sci 68:2151-2158.
32. _, Gao J, Liu Q. 2003. A novel lectin from the wild mushroom Polyporus adusta. Biochem Biophys Res Commun 307:535-539.
33. Wang HX, Liu WK, Ng TB, Ooi VEC, Chang ST. 1996. The immunomodulatory and antitumor activities of lectins from the mushroom Tricholoma mongolicum Immunopharmacol 31:205-211.
34. _, Ng TB. 2000. Flammulin: a novel ribosome-inactivating protein from fruiting bodies of the winter mushroom Flammulina velutipes. Biochem Cell Biol 78:699-702.
35. _, Liu QH. 2002. Isolation of a new heterodimeric lectin with mitogenic activity from fruiting bodies of the mushroom Agrocybe cylindracea. Life Sci 70:877-886.
36. _, Liu WK, Ooi VEC, Chang ST. 1995. Isolation and characterization of two distinct lectins with antiproliferative activity from the cultured mycelium of the edible mushroom Tricholoma mongolicum. Int J Peptide Protein Res 46:508-513.
37. _, Ooi VEC. 1998. Lectins from mushrooms. Mycol Res 102:897-906.
38. _, Liu WK, Chang ST. 1997. Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice. Anticancer Res 17:419-424.
39. _, Ooi VEC, Ng TB, Chiu KW, Chang ST. 1996. Hypotensive and vasorelaxing activities of a lectin from the edible mushroom Tricholoma mongolicum. Pharmacol Toxicol 79:318-323.
40. Yagi F, Miyamoto M, Abe T, Minami T, Tadera K, Goldstein IJ. 1997. Purification and carbohydrate-binding specificity of Agrocybe cylindracea lectin. Glycoconjugate J 14:281-288.
41. Ye XY, Ng TB, Tsang PW, Wang J. 2001. Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds. J Protein Chem 20:367-375.
42. Yu LG, Fernig DG, Rhodes JM. 2000. Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells. Eur J Biochem 267:2122-2126.
43. _, Smith JA, Milton JD, Rhodes JM. 1993. Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin. Cancer Res 53:4627-4632.
44. Yoshioka Y, Tabeta R, Saito H, Uehara N, Fukuoka F. 2003. Antitumor polysaccharides Zhao C, Sun H, Tong X, Qi Y. An antitumour lectin from the edible mushroom Agrocybe aegerita. Biochem J 374:321-327.
45. Zhuang C, Murata T, Usui T, Kawagishi H, Kobayashi K. 1996. Purification and characterization of a lectin from the toxic mushroom Amanita pantherina. Biochim Biophys Acta 1291:40-44.