Metabolic effects of caffeine ingestion and physical work in 75-year old citizens. A randomized, double-blind, placebo-controlled, cross-over study

Clinical Endocrinology

Volumn 65, Issue 2, 2006, Pages 223-228

  Norager, C B ^a   Jensen, M B ^b   Weimann, A ^c   Madsen, M R ^a  

^a HERNING HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CAFFEINE; FATTY ACID; INSULIN; LACTIC ACID; PLACEBO; POTASSIUM;

ADRENALIN BLOOD LEVEL; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYCLING; DRIVER LICENCE; EXERCISE; EXHAUSTION; EXPECTATION; FATTY ACID BLOOD LEVEL; FEMALE; FOOD INTAKE; GENERAL PRACTITIONER; HEART RATE; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; INSULIN RESISTANCE; INSULIN SENSITIVITY; LACTATE BLOOD LEVEL; MALE; MANUAL LABOR; MEDICAL EXAMINATION; PHYSICAL STRESS; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; REST;

ADMINISTRATION, ORAL; AGED; BLOOD GLUCOSE; CAFFEINE; CALCIUM; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENERGY METABOLISM; EPINEPHRINE; EXERCISE TEST; FATTY ACIDS, NONESTERIFIED; FEMALE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; LACTIC ACID; MALE; POTASSIUM; STATISTICS, NONPARAMETRIC;

EID: 33746046084     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2006.02579.x     Document Type: Article

References (35)

1. Graham, T.E. & Spriet, L.L. (1991) Performance and metabolic responses to a high caffeine close during prolonged exercise. Journal of Applied Physiology, 71, 2292-2298.
2. Graham, T.E., Sathasivam, P., Rowland, M., Marko, N., Greer, F. & Battram, D. (2001) Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test. Canadian Journal of Physiological Pharmacology, 79, 559-565.
3. Graham, T.E., Helge, J.W., MacLean, D.A., Kiens, B. & Richter, E.A. (2000) Caffeine ingestion does not alter carbohydrate or fat metabolism in human skeletal muscle during exercise. Journal of Physiology, 529, 837-847.
4. Bangsbo, J., Jacobsen, K., Nordberg, N., Christensen, N.J. & Graham, T. (1992) Acute and habitual caffeine ingestion and metabolic responses to steady-state exercise. Journal of Applied Physiology, 72, 1297-1303.
5. Van Soeren, M.H., Sathasivam, P., Spriet, L.L. & Graham, T.E. (1993) Caffeine metabolism and epinephrine responses during exercise in users and nonusers. Journal of Applied Physiology, 75, 805-812.
6. Lindinger, M.I., Graham, T.E. & Spriet, L.L. (1993) Caffeine attenuates the exercise-induced increase in plasma [K+] in humans. Journal of Applied Physiology, 74, 1149-1155.
7. Jackman, M., Wendling, P., Friars, D. & Graham, T.E. (1996) Metabolic catecholamine, and endurance responses to caffeine during intense exercise. Journal of Applied Physiology, 81, 1658-1663.
8. Tarnopolsky, M.A., Atkinson, S.A., MacDougall, J.D., Sale, D.G. & Sutton, J.R. (1989) Physiological responses to caffeine during endurance running in habitual caffeine users. Medicine and Science in Sports and Exercise, 21, 418-424.
9. Van Soeren, M.H. & Graham, T.E. (1998) Effect of caffeine on metabolism, exercise endurance, and catecholamine responses after withdrawal. Journal of Applied Physiology, 85, 1493-1501.
10. Poehlman, E.T., LaChance, P., Tremblay, A., Nadeau, A., Dussault, J., Theriault, G., Despres, J.P. & Bouchard, C. (1989) The effect of prior exercise and caffeine ingestion on metabolic rate and hormones in young adult males. Canadian Journal of Physiological Pharmacology, 67, 10-16.
11. Graham, T.E. & Spriet, L.L. (1995) Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. Journal of Applied Physiology, 78, 867-874.
12. Bell, D.G., Jacobs, I. & Zamecnik, J. (1998) Effects of caffeine, ephedrine and their combination on time to exhaustion during high-intensity exercise. European Journal of Applied Physiology and Occupational Physiology, 77, 427-433.
13. Kovacs, E.M., Stegen, J.H.C.H. & Brouns, F. (1998) Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance. Journal of Applied Physiology, 85, 709-715.
14. Chesley, A., Howlett, R.A., Heigenhauser, G.J., Hultman, E. & Spriet, L.L. (1998) Regulation of muscle glycogenolytic flux during intense aerobic exercise after caffeine ingestion. American Journal of Physiology, 275, R596-R603.
15. Bruce, C.R., Anderson, M.E., Fraser, S.F., Stepto, N.K., Klein, R., Hopkins, W.G. et al. (2000,) Enhancement of 2000-m rowing performance after caffeine ingestion. Medicine and Science in Sports and Exercise, 32, 1958-1963.
16. Graham, T.E. (2001) Caffeine and exercise: metabolism, endurance and performance. Sports Medicine, 31, 785-807.
17. Bell, D.G., Jacobs, I. & Ellerington, K. (2001) Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Medicine and Science in Sports and Exercise, 33, 1399-1403.
18. Collomp, K., Candau, R., Millet, G., Mucci, P., Borrani, F., Prefaut, C. & De Ceaurriz, J. (2002) Effects of salbutamol and caffeine ingestion on exercise metabolism and performance. International Journal of Sports Medicine, 23, 549-554.
19. Graham, T.E., Sathasivam, P. & MacNaughton, K.W. (1991) Influence of cold, exercise, and caffeine on catecholamines and metabolism in men. Journal of Applied Physiology, 70, 2052-2058.
20. Costill, D.L., Dalsky, G.P. & Fink, W.J. (1978) Effects of caffeine ingestion on metabolism and exercise performance. Medicine and Science in Sports, 10, 155-158.
21. Denadai, B.S. & Denadai, M.L. (1998) Effects of caffeine on time to exhaustion in exercise performed below and above the anaerobic threshold. Brazilian Journal of Medical and Biological Research, 31, 581-585.
22. Greer, F., McLean, C. & Graham, T.E. (1998) Caffeine, performance, and metabolism during repeated Wingate exercise tests. Journal of Applied Physiology, 85, 1502-1508.
23. Arciero, P.J., Gardner, A.W., Calles-Escandon, J., Benowitz, N.E. & Poehlman, E.T. (1995) Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men. American Journal of Physiology, 268, E1192-E1198.
24. Norager, C.B., Jensen, M.B., Madsen, M.R. & Laurberg, S. (2005) Caffeine improves endurance in 75-year old citizens. A randomized, double-blind, placebo-controlled, cross-over study. Journal of Applied Physiology, 99, 2302-2306.
25. Andersen, L., Dinesen, B., Jorgensen, P.N., Poulsen, F. & Roder, M.E. (1993) Enzyme immunoassay for intact human insulin in serum or plasma. Clinical Chemistry 39, 578-582.
26. Carstensen, E. & Yudkin, J.S. (1994) Platelet catecholamine concentrations after short-term stress in normal subjects. Clinical Science, 86, 35-41.
27. Weinmann, S., Siscovick, D.S., Raghunathan, T.E., Arbogast, P., Smith, H., Bovbjerg, V.E., Cobb, L.A. & Psaty, B.M. (1997) Caffeine intake in relation to the risk of primary cardiac arrest. Epidemiology, 8, 505-508.
28. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F. & Turner, R.C. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419.
29. Nehlig, A., Daval, J.L. & Debry, G. (1992) Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Research. Brain Research Review, 17, 139-170.
30. Olah, M.E. & Stiles, G.L. (1995) Adenosine receptor subtypes: characterization and therapeutic regulation. Annual Review of Pharmacological Toxicology, 35, 581-606.
31. Lee, S., Hudson, R., Kilpatrick, K., Graham, T.E. & Ross, R. (2005) Caffeine ingestion is associated with reductions in glucose uptake independent of obesity and type 2 diabetes before and after exercise training. Diabetes Care, 28, 566-572.
32. Thong, P.S. & Graham, T.E. (2002) Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. Journal of Applied Physiology, 92, 2347-2352.
33. Mohr, T., Van Soeren, M., Graham, T.E. & Kjaer, M. (1998) Caffeine ingestion and metabolic responses of tetraplegic humans during electrical cycling. Journal of Applied Physiology, 85, 979-985.
34. Bauer, T. & Weisser, B. (2002) [Effect of aerobic endurance exercise on immune function in elderly athletes]. Schweiz Rundsch Medical Prax, 91, 153-158.
35. Brubaker, P.H., Marburger, C.T., Morgan, T.M., Fray, B. & Kitzman, D.W. (2003) Exercise responses of elderly patients with diastolic versus systolic heart failure. Medicine and Science in Sports and Exercise, 35, 1477-1485.